Effects of terazosin: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Research Findings

Terazosin, an alpha-blocker, has been shown to be effective in treating various conditions, including benign prostatic hyperplasia (BPH), hypertension, and congestive heart failure. 15 , 12 , 4 , 5 , 2 , 10 , 6 , 14 , 1 , 16 , 17 , 13 , 8 For BPH, terazosin relaxes the muscles in the prostate, improving urine flow. 15 For hypertension, terazosin relaxes blood vessels, lowering blood pressure. 4 , 5 , 2 , 10 , 6 , 14 , 1 , 17 , 13 Additionally, terazosin may also have benefits for prostate cancer, particularly in combination with genistein, a soy isoflavone. 11 Research suggests that terazosin, when combined with diuretics, is a safe and effective treatment for hypertension. 4 Furthermore, terazosin, when combined with extracorporeal magnetic innervation (ExMI), may be more effective than terazosin alone in treating chronic pelvic pain syndrome. 7

Benefits and Risks

Benefit Summary

Terazosin can improve symptoms of BPH, treat hypertension, and potentially offer benefits for prostate cancer and chronic pelvic pain syndrome. It can also be effective when combined with diuretics for hypertension and with ExMI for chronic pelvic pain syndrome.

Risk Summary

Common side effects of terazosin include dizziness, headache, fatigue, and nasal congestion. 4 , 5 , 3 As it can lower blood pressure, it may cause lightheadedness, particularly when standing up. 5 , 18 It may also lead to weight gain. 4 Always consult with your doctor before taking terazosin, especially if you are on other medications, as it may interact with other drugs.

Comparison Between Studies

Commonalities

Across multiple studies, terazosin has demonstrated effectiveness in treating BPH, hypertension, and other conditions. It is generally well-tolerated and considered safe.

Differences

The effectiveness and side effects of terazosin can vary depending on the specific condition being treated and the individual patient. It is crucial to discuss with your doctor if terazosin is right for you and any potential interactions it may have with other medications.

Consistency and Inconsistencies in the Findings

While numerous studies suggest terazosin's efficacy for various conditions, its impact and potential side effects can differ based on factors like individual patient characteristics and other medications being taken.

Important Considerations for Real-World Application

Always consult with your doctor before starting or stopping any medication. Terazosin should be taken under medical supervision. It is particularly important to be cautious when standing up as it can lead to lightheadedness. Be sure to inform your doctor about all medications you are taking, as terazosin may interact with other drugs.

Limitations of Current Research

More research is needed to fully understand the long-term effects and potential side effects of terazosin, especially in relation to its interactions with other medications.

Future Research Directions

Future research should focus on understanding the long-term effects and potential side effects of terazosin, as well as its interactions with other medications. It's also essential to conduct more research on how terazosin can be effectively used for various conditions.

Conclusion

Terazosin, an alpha-blocker, has shown promise in treating various conditions, including BPH, hypertension, and congestive heart failure. While generally safe and well-tolerated, it can have side effects, and its effectiveness can vary depending on individual factors. Consult your doctor for personalized guidance regarding the use of terazosin.

Literature analysis of 19 papers
Positive Content
19
Neutral Content
0
Negative Content
0
Article Type
10
1
1
3
19
1.

The safety and efficacy of terazosin in the treatment of essential hypertension in blacks.

Author: SaundersE

Favorable lipid effects
Lower blood pressure
Well tolerated
Minimal side effects

Terazosin, a new selective alpha1-adrenergic receptor antagonist, was effective in lowering blood pressure in black patients with hypertension, both when used alone and in combination with other medications. It was well-tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Antihypertensive effectiveness of terazosin: a new long-acting alpha-adrenergic inhibitor.

Author: ChrysantS G, BalI S, JohnsonB, McPhersonM A

Reduced blood pressure
Safe and well tolerated

Terazosin, a new long-acting alpha blocker, was effective in treating hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Comparative trials of terazosin with other antihypertensive agents.

Author: RuoffG

Effective for hypertension
Well-tolerated
Asthenia
Dizziness
Headache
Malaise
Nasal congestion

Terazosin exhibited similar antihypertensive activity to prazosin in patients with mild to moderate hypertension. It was well tolerated at doses ranging from 1 to 10 mg twice daily. The most common side effects were headache, dizziness, malaise, asthenia, and nasal congestion.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Cumulative experience with terazosin administered in combination with diuretics.

Author: RuddP

Effective for hypertension
Asthenia
Dizziness
Headache
Weight gain

Terazosin, when combined with a diuretic, was found to be safe and effective in the treatment of hypertension. It significantly decreased blood pressure in 56% of patients compared to 29% of control subjects. The most common side effects were dizziness, headache, and asthenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Efficacy and safety of intravenous terazosin in hypertensive patients. A preliminary report.

Author: CohenA

Long-lasting effect
Lower blood pressure
Headache
Light-headedness
Nasal congestion

Terazosin, administered intravenously, effectively reduced blood pressure in hypertensive patients. The onset of action occurred within 2 hours, and the effect lasted for at least 6 hours in 40% of responders. The most common side effects were headache, nasal congestion, and light-headedness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men.

Author: KirbyR S

Does not adversely affect antihypertensive medication
Safe treatment for BPH

Terazosin is a safe treatment for benign prostatic hyperplasia (BPH) in both normotensive and hypertensive men, including those already taking antihypertensive medications. The drug lowered blood pressure in hypertensive patients but did not significantly affect blood pressure in normotensive or controlled hypertensive individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Rest and exercise cardiovascular effects of terazosin in congestive heart failure.

Author: MagorienR D, SinnathambyS, LeierC V, BoudoulasH, UnverferthD V

Decreased oxygen consumption
Improved myocardial circulation

Terazosin, an alpha 1 antagonist, reduced pulmonary capillary wedge pressure and systemic vascular resistance, improving myocardial circulatory parameters without inducing coronary dilation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with untreated essential hypertension.

Author: LytleT, ColesS, WaiteM A

Blood pressure reduction
Reduced cholesterol
None mentioned

Terazosin hydrochloride, an alpha1-adrenergic receptor antagonist, was effective in lowering blood pressure and reducing total cholesterol levels in 69 patients with mild-moderate hypertension. The drug was well-tolerated and safe for once-daily administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

11.

Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line.

Author: ChangKee-Lung, ChengHsiao-Ling, HuangLi-Wen, HsiehBau-Shan, HuYu-Chen, ChihTsai-Tung, ShyuHuey-Wen, SuShu-Jem

Treat prostate cancer

This study investigated the therapeutic potential of combining terazosin and genistein, two drugs with anticancer properties, for treating metastatic, androgen-independent prostate cancer. The combination was more effective in inhibiting cell growth and VEGF expression and inducing apoptosis than either drug alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of branded versus generic terazosin hydrochloride in adults with benign prostatic hyperplasia: a randomized, open-label, crossover study in Taiwan.

Author: TsaiYuh-Shyan, LanShih-Kai, OuJiann-Hui, TzaiTzong-Shin

Benign prostatic hyperplasia treatment

Terazosin is an alpha1-selective adrenoceptor blocking agent that has been shown to be effective in treating benign prostatic hyperplasia (BPH). This article discusses the need for an effective and well-tolerated generic formulation of terazosin to improve cost-effectiveness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A comparison of the effects of the selective peripheral alpha 1-blocker terazosin with the selective beta 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension.

Author: LiguerosM, UnwinR, WilkinsM R, HumphreysJ, ColesS J, ClelandJ

Control pressor response
Reduce blood pressure
Reduced cholesterol

This study compared the effects of the alpha 1-adrenoceptor blocker terazosin and the beta 1-adrenoceptor blocker atenolol in patients with mild-to-moderate hypertension. Both drugs reduced blood pressure, but terazosin showed potential benefits in reducing total cholesterol and improving the HDL/LDL cholesterol ratio.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Terazosin for treating symptomatic benign prostatic obstruction: a systematic review of efficacy and adverse effects.

Author: WiltT J, HoweW, MacDonaldR

Improved flow rates
Improved symptoms
Adverse effects
Increased treatment discontinuation

Terazosin is effective in improving symptoms and flow rates associated with benign prostatic obstruction (BPO). It is more effective than placebo or finasteride and similar to other alpha-antagonists. However, terazosin is associated with more adverse effects than placebo, including dizziness, asthenia, headache, and postural hypotension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

[Pressure and metabolic effects of terazosin in essential hypertension].

Author: ValleR, SempliciniA, SerenaL, GebbinA, FontebassoA, GerardiG, De ToniR, PessinaA C

Lower blood pressure
Safe for long-term use
Salt and water retention
Weight gain

Terazosin, an alpha-1 blocker, was evaluated for its efficacy and safety in treating essential hypertension. In 12 patients, terazosin at a dose of 2 mg/day effectively lowered diastolic blood pressure. Higher doses were associated with increased body weight, suggesting potential for fluid retention.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

18.

[Effects of terazosin on the blood pressure responses to tilting in conscious animals: comparison with prazosin].

Author: BesshoH, HaraY, KimuraY, NarimatsuA, HoriiD, TobeA

Reduced orthostatic hypotension
Blood pressure reduction

Terazosin was found to be less likely to cause orthostatic hypotension than prazosin in rabbits and spontaneously hypertensive rats. This suggests that terazosin may be a safer antihypertensive agent for patients at risk for orthostatic hypotension.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

19.

Pharmacokinetic and pharmacodynamic modelling of arterial haemodynamic effects of terazosin in healthy volunteers.

Author: CampaneroMiguel Angel, SádabaBelén, Muñoz-JuarezMaria José, QuetglasEmilio García, AzanzaJose Ramón

Blood pressure control

This study investigated the relationship between plasma terazosin concentrations and its effects on arterial blood pressure in healthy volunteers. Pharmacokinetic and pharmacodynamic modeling was performed to describe the pharmacodynamic relationship between blood pressure and terazosin concentration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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