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Safety and immunogenicity of a pentavalent vaccine compared with separate administration of licensed equivalent vaccines in US infants and toddlers and persistence of antibodies before a preschool booster dose: a randomized, clinical trial.

Author: , BlatterMark M, GreenbergDavid P, GuerraFernando A, NoriegaFernando R, PichicheroMichael

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the safety and immunogenicity of a combination vaccine (Pentacel) with its separately administered equivalent vaccines in infants and toddlers. Results showed no difference in safety and immunogenicity between the combination and separate vaccines.
Paper Details　
Original Abstract of the Article :
Our goal was to compare the safety and immunogenicity of a combination vaccine (DTaP(5)-IPV-Hib; Pentacel) with that of its separately administered, US-licensed equivalent vaccines (diphtheria, tetanus, 5-component acellular pertussis vaccine [DTaP(5); Daptacel], inactivated poliovirus vaccine [IPV;...See full text at original site
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引用元：
https://doi.org/10.1542/peds.2007-3317

データ提供：米国国立医学図書館（NLM）

Pentavalent Vaccine: A Safe and Effective Option for Infants and Toddlers

Immunization, a cornerstone of public health, continues to evolve, with new vaccine combinations offering greater convenience and efficacy. This study compares the safety and immunogenicity of a pentavalent vaccine (DTaP(5)-IPV-Hib; Pentacel) with that of its separately administered, equivalent vaccines. The authors examine the antibody persistence from the fourth dose to the fifth dose in toddlers.

The study provides strong evidence for the safety and efficacy of the pentavalent vaccine, demonstrating that it is comparable to separately administered vaccines in terms of immunogenicity and antibody persistence. The study highlights the benefits of using a combination vaccine, particularly in terms of convenience and reducing the number of injections for infants and toddlers.

Simplifying Immunizations

This research underscores the importance of simplifying the immunization schedule for infants and toddlers. The study demonstrates that combination vaccines, like the pentavalent vaccine, provide a safe and effective way to protect children from multiple diseases with fewer injections.

Protecting Children: A Collective Effort

This study emphasizes the importance of vaccination in protecting children from preventable diseases. The findings highlight the safety and efficacy of combination vaccines, contributing to ongoing efforts to promote high vaccination rates and protect children from serious illnesses.

Dr.Camel's Conclusion

Just as a desert caravan travels together for safety and support, combination vaccines offer a unified approach to protecting children from multiple diseases. This study provides evidence for the safety and efficacy of the pentavalent vaccine, reinforcing the importance of vaccination in safeguarding the health of our youngest travelers.

Date :
  1. Date Completed 2009-02-06
  2. Date Revised 2009-11-19
Further Info :

Pubmed ID

19117896

DOI: Digital Object Identifier

10.1542/peds.2007-3317

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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