The clinical pharmacology of ethacrynic acid.

Author: MolnarJanos, SombergJohn C

Paper Details 
Original Abstract of the Article :
Ethacrynic acid (Edecrin) is a loop diuretic that produces a prompt and profound diuresis. The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an ...See full text at original site
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引用元:
https://doi.org/10.1097/MJT.0b013e318195e460

データ提供:米国国立医学図書館(NLM)

Ethacrynic Acid: A Powerful Diuretic in the Desert of Edema

Edema, the accumulation of excess fluid in body tissues, can be likened to a desert oasis that has become flooded, causing discomfort and dysfunction. This article reviews the clinical pharmacology of ethacrynic acid, a loop diuretic known for its prompt and profound diuretic effect. The author explains the mechanism of action of ethacrynic acid, highlighting its ability to inhibit the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle, leading to increased urine production and fluid removal. The article also discusses the pharmacokinetics, efficacy, and side effects of ethacrynic acid.

Ethacrynic Acid: A Powerful Tool for Managing Edema

This article provides a comprehensive overview of ethacrynic acid, highlighting its potential for effectively managing edema in various conditions, including congestive heart failure and other edematous states. The author's detailed explanation of the drug's pharmacokinetics and clinical applications provides valuable information for healthcare providers and researchers. The review also underscores the importance of carefully monitoring patients for potential side effects, particularly ototoxicity.

Navigating the Desert of Edema: A Holistic Approach to Treatment

This article emphasizes the importance of a holistic approach to managing edema, taking into account individual patient needs and potential side effects. The review of ethacrynic acid highlights the need for careful consideration of drug selection and dosage to optimize treatment outcomes and minimize potential risks. The desert of edema can be a challenging landscape to navigate, but this review provides valuable insights into the use of ethacrynic acid as a potential tool for managing this condition.

Dr.Camel's Conclusion

The desert of edema can be a challenging landscape to navigate, but ethacrynic acid, a powerful diuretic, can serve as a valuable tool for managing this condition. This review provides a comprehensive overview of the drug's pharmacokinetics, efficacy, and side effects, offering valuable insights for healthcare providers and researchers. It's important to remember that the desert of edema requires a holistic approach to treatment, ensuring that the benefits of diuretic therapy outweigh the potential risks.

Date :
  1. Date Completed 2013-01-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19142159

DOI: Digital Object Identifier

10.1097/MJT.0b013e318195e460

Related Literature

SNS
PICO Info
in preparation
Languages

English

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