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Computational molecular docking assessment of hormone receptor adjuvant drugs: Breast cancer as an example.

Author: MajumderDurjoy, MukherjeeSayan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Hormone receptor antagonists used in breast cancer treatment may have adverse effects due to their interactions with other receptors in the body.
Paper Details　
Original Abstract of the Article :
For the maintenance therapy of breast cancer, drugs which act as antagonists/partial agonists of hormone receptors against the breast tissue are used in the conventional clinical practices. However, during the course of treatment the patients may encounter systems related complications. Drugs like t...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/j.pathophys.2008.12.001

データ提供：米国国立医学図書館（NLM）

Hormone Receptor Adjuvant Drugs: Exploring the Desert of Potential Side Effects

Breast cancer, a challenging disease that affects many women, often requires hormone receptor adjuvant drugs as part of its treatment. This study, like a camel navigating the vast desert of drug interactions, investigates the potential side effects of these drugs by using molecular docking methods. The study examines the binding of commonly used drugs like tamoxifen, raloxifene, toremifene, and mifepristone to various receptors in the body. The study found that these drugs exhibit varying degrees of binding affinity to various receptors, potentially explaining their observed toxicities.

Hormone Receptor Adjuvant Drugs: Unveiling the Hidden Landscape of Potential Side Effects

This study provides valuable insights into the potential side effects of commonly used hormone receptor adjuvant drugs for breast cancer. The study’s findings highlight the importance of carefully monitoring patients for potential complications and considering alternative treatment options when necessary.

Navigating the Desert: Awareness and Informed Choices

This research underscores the need for a comprehensive understanding of the potential side effects of hormone receptor adjuvant drugs. Just as a camel navigates a desert landscape with caution, individuals undergoing breast cancer treatment should consult with their healthcare providers to discuss potential risks and benefits.

Dr. Camel's Conclusion

This study reminds us that the journey to combatting breast cancer is not always straightforward. Like a camel navigating a desert, researchers continue to explore the complexities of drug interactions, aiming to minimize potential side effects and maximize treatment effectiveness.

Date :
  1. Date Completed 2012-10-02
  2. Date Revised 2020-09-29
Further Info :

Pubmed ID

19147336

DOI: Digital Object Identifier

10.1016/j.pathophys.2008.12.001

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Languages

English

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