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Clinical trial: the treatment of gastro-oesophageal reflux disease in primary care--prospective randomized comparison of rabeprazole 20 mg with esomeprazole 20 and 40 mg.

Author: , EgglestonA, HoltmannG, KatelarisP H, NandurkarS, ThorpeP

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Rabeprazole 20 mg was non-inferior to esomeprazole 40 mg for complete resolution of regurgitation and satisfactory resolution of heartburn and regurgitation. Rabeprazole 20 mg was also non-inferior to esomeprazole 20 mg for all outcomes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A trial of empirical PPI therapy is usual practice for most patients with symptoms of gastro-oesophageal reflux disease (GERD) in primary care. AIM: To determine if the 4-week efficacy of rabeprazole 20 mg for resolving heartburn and regurgitation symptoms is non-inferior to esomeprazol...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2009.03948.x

データ提供：米国国立医学図書館（NLM）

Proton Pump Inhibitors: A Comparative Analysis of Efficacy

The field of [gastro-oesophageal reflux disease (GERD) treatment] explores effective and safe approaches to manage the symptoms of heartburn and regurgitation. This study examines the efficacy of two proton pump inhibitors (PPIs), [rabeprazole] and [esomeprazole], in treating GERD. The study used a [randomized, double-blind design] to compare the effectiveness of these medications in a group of patients with GERD. The research shows that [rabeprazole 20 mg] was [non-inferior] to [esomeprazole 40 mg] in resolving regurgitation symptoms and providing satisfactory relief from both heartburn and regurgitation. Furthermore, rabeprazole 20 mg was [non-inferior] to esomeprazole 20 mg for all outcomes. The researchers conclude that [rabeprazole 20 mg] is an effective and well-tolerated treatment option for GERD.

A Desert of Choices: Navigating Proton Pump Inhibitor Options

The study's findings suggest that [rabeprazole 20 mg] is a viable alternative to [esomeprazole 40 mg] for managing GERD symptoms. This finding could be beneficial for patients seeking a [cost-effective] treatment option.

GERD Treatment: A Journey Through a Desert of Symptoms

GERD is a common condition that can significantly impact an individual's quality of life. This study explores the effectiveness of different PPIs in treating GERD. The study suggests that [rabeprazole 20 mg] is a [non-inferior] treatment option to [esomeprazole 40 mg] for many patients with GERD.

Dr. Camel's Conclusion

This study is a journey through the desert of GERD, exploring the effectiveness of different PPIs. The researchers found that [rabeprazole 20 mg] was a [non-inferior] option to [esomeprazole 40 mg] in treating GERD symptoms. Just like a camel navigating a vast and arid landscape, we must continue to explore and evaluate different treatment options to find the most effective and safe solutions for our patients.

Date :
  1. Date Completed 2009-10-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19210493

DOI: Digital Object Identifier

10.1111/j.1365-2036.2009.03948.x

Related Literature

Article Analysis
・Effective treatment of gerd
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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