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Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine.

Author: CamerinoDiana Conte, CostanzaTeresa, De BellisMichela, DelmasPatrick, DesaphyJean-François, DipalmaAntonella, GaudiosoChristelle, GeorgeAlfred L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Orphenadrine is a medication used to treat muscle spasms and Parkinson's disease. It is also used for pain relief, but its mechanism of action is unknown. This study found that orphenadrine blocks sodium channels, which are involved in transmitting pain signals. This may explain why orphenadrine is effective for pain relief.
Paper Details　
Original Abstract of the Article :
Orphenadrine is a drug acting on multiple targets, including muscarinic, histaminic, and NMDA receptors. It is used in the treatment of Parkinson's disease and in musculoskeletal disorders. It is also used as an analgesic, although its mechanism of action is still unknown. Both physiological and pha...See full text at original site
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引用元：
https://doi.org/10.1016/j.pain.2009.01.010

データ提供：米国国立医学図書館（NLM）

Orphenadrine: A Potential Solution to the Desert of Pain

Orphenadrine, a medication commonly used to alleviate musculoskeletal pain, has been shown to have analgesic effects, but its mechanism of action has remained elusive. This research, like a meticulous desert explorer, investigates the potential role of voltage-gated sodium channels in orphenadrine’s analgesic properties. The study, like a carefully crafted experiment in a desert laboratory, explores the interaction between orphenadrine and sodium channels, seeking to unveil the mechanisms underlying its pain-relieving effects.

Unveiling the Secrets of Orphenadrine’s Analgesic Action

The findings suggest that orphenadrine can effectively block voltage-gated sodium channels, potentially explaining its analgesic effects. It’s like discovering a hidden spring in the desert, providing a source of relief from the pain. The study emphasizes the importance of considering the potential proconvulsive and proarrhythmic adverse effects of orphenadrine, particularly at higher doses.

Navigating the Desert of Pain Management

This research offers valuable insights into the mechanism of action of orphenadrine. It’s like discovering a new path through the desert of pain management, shedding light on the complex interplay of factors that contribute to pain perception. The findings encourage further investigation into the therapeutic potential of orphenadrine and its potential role in managing chronic pain conditions.

Dr. Camel’s Conclusion

This research provides a deeper understanding of the analgesic properties of orphenadrine. It underscores the importance of carefully considering the potential risks and benefits of this medication, particularly in the context of chronic pain management.
Date :
  1. Date Completed 2009-05-05
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

19217209

DOI: Digital Object Identifier

10.1016/j.pain.2009.01.010

Related Literature

Article Analysis
・Effects of orphenadrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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