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Rabeprazole: a pharmacologic and clinical review for acid-related disorders.

Author: DadabhaiAlia, FriedenbergFrank K

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Rabeprazole, a proton pump inhibitor, is effective in treating acid-peptic-related disorders such as GERD, duodenal ulcers, gastric ulcers, and gastric acid hypersecretory syndromes. Its higher pKa of approximately 5.0 allows it to be activated at a higher pH than other proton pump inhibitors, potentially leading to faster onset of action. Rabeprazole's non-enzymatic metabolism makes it less susceptible to CYP2C19 genetic polymorphisms, unlike other proton pump inhibitors. Clinical studies have demonstrated the rapid and effective relief of heartburn and improvement of other GERD-related symptoms with rabeprazole, including regurgitation, belching, bloating, early satiety, and nausea. It is generally safe and well-tolerated with minimal side effects.
Paper Details　
Original Abstract of the Article :
Rabeprazole is a proton pump inhibitor that can be used in the treatment of acid-peptic-related disorders (gastroesophageal reflux disease [GERD], duodenal ulcer, gastric ulcer, gastric acid hypersecretory syndromes) and Helicobacter pylori. Pharmacodynamic data has demonstrated that rabeprazole, wi...See full text at original site
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引用元：
https://doi.org/10.1517/14740330802622892

データ提供：米国国立医学図書館（NLM）

Rabeprazole: A Pharmacologic and Clinical Review for Acid-Related Disorders

Acid-related disorders, such as gastroesophageal reflux disease (GERD), can significantly impact an individual's quality of life. This research, a journey through the desert of gastrointestinal treatments, explores the pharmacologic and clinical profile of rabeprazole, a proton pump inhibitor used to treat acid-related disorders.

A Potent Inhibitor: Targeting the Proton Pump

Rabeprazole, like a precise desert explorer, specifically targets the proton pump, a crucial enzyme responsible for gastric acid production. This selective action effectively reduces gastric acid levels, providing relief from symptoms associated with acid-related disorders.

Efficacy and Safety: A Balanced Approach

The research highlights the efficacy of rabeprazole in treating a wide range of acid-related disorders, including GERD, duodenal ulcer, gastric ulcer, and Helicobacter pylori infection. Additionally, the study underscores the safety profile of rabeprazole, with few reported side effects.

Health Implications and Everyday Life: A Path to Relief

This research, a beacon of hope in the desert of acid-related disorders, provides valuable insights into the effectiveness and safety of rabeprazole. For individuals struggling with acid-related disorders, this research offers a potential for effective relief and improved quality of life.

Dr. Camel's Conclusion

This research, a meticulous exploration in the desert of gastrointestinal treatments, highlights the effectiveness and safety of rabeprazole. The findings suggest that rabeprazole may offer a valuable treatment option for acid-related disorders, providing relief for individuals seeking a more comfortable and fulfilling life.

Date :
  1. Date Completed 2009-05-26
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

19236223

DOI: Digital Object Identifier

10.1517/14740330802622892

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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