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CpG-C oligodeoxynucleotides limit the deleterious effects of beta-adrenoceptor stimulation on NK cytotoxicity and metastatic dissemination.

Author: Ben-EliyahuShamgar, BenishMarganit, GlasnerAriella, GoldfarbYael, LeviBen, MelamedRivka, RosenneElla

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Suppression of natural killer (NK) cell activity is a common consequence of stress, has been associated with malignant recurrence in cancer patients, and has been shown to underlie metastatic dissemination in animal models. The study examined the prophylactic use of type-C CpG oligodeoxynucleotides (CpG-C ODN) in a pharmacologic stress model using metaproterenol for beta-adrenoceptor stimulation in Fisher 344 rats. The results indicated that the beneficial effects of CpG-C ODN were more pronounced under pharmacologic stress than under baseline conditions. A bolus of CpG-C ODN (330 microg/kg, intraperitoneally) 24 hours before metaproterenol challenge was most effective in reducing lung tumor retention of an experimental syngeneic mammary adenocarcinoma (MADB106) without observable side effects. NK cell depletion revealed their crucial role in improving baseline resistance to metastatic dissemination after CpG-C ODN administration. Assessment of NK cell cytotoxicity in the circulation and marginating-pulmonary immune compartments showed that CpG-C ODN protected individual NK cells from metaproterenol-induced suppression in both compartments. Moreover, in the marginating-pulmonary compartment, CpG-C ODN elevated baseline cytotoxicity per NK cell against MADB106 tumor cells and increased NK cell numbers in nonstressed rats. In conclusion, prophylactic CpG-C ODN treatment can improve immunocompetence and potentially reduce metastatic dissemination, particularly in clinical settings with enhanced sympathetic stress responses.
Paper Details　
Original Abstract of the Article :
Suppression of natural killer (NK) cell activity is common after stress, has been reported to predict malignant recurrence in cancer patients, and was shown to underlie metastatic dissemination in animal models. We have previously reported that catecholamines play a major role in NK cell suppression...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19242372

データ提供：米国国立医学図書館（NLM）

Boosting the Immune System: CpG-C Oligodeoxynucleotides for Cancer Treatment

This [study] explores the potential of [CpG-C oligodeoxynucleotides (CpG-C ODN)] as a therapeutic agent for [cancer patients]. It's like finding a hidden oasis in the vast desert of cancer research, seeking new ways to bolster the body's natural defenses and fight the disease.

The study found that [CpG-C ODN] effectively limited the [deleterious effects of beta-adrenoceptor stimulation] on [natural killer (NK) cell cytotoxicity] and [metastatic dissemination] in an animal model. This suggests that CpG-C ODN could have a therapeutic role in enhancing the immune response in cancer patients. The authors also noted that CpG-C ODN was particularly effective under conditions of [pharmacologic stress], suggesting that it could be a valuable tool for mitigating the negative effects of stress on the immune system.

A Glimmer of Hope: Enhancing the Immune Response in Cancer Treatment

This study offers a promising new avenue for cancer treatment, suggesting that [CpG-C ODN] could play a role in boosting the immune system and improving outcomes for patients.

A Desert of Discovery: Unlocking the Potential of the Immune System

This research is a testament to the ongoing exploration of the immune system's potential to fight disease. It's like a desert expedition, where every new discovery leads to a deeper understanding of the complex and often overlooked role of the immune system in human health.

Dr. Camel's Conclusion

This study is like a desert wind carrying a message of hope, suggesting that CpG-C ODN could be a valuable tool for harnessing the power of the immune system to fight cancer.

Date :
  1. Date Completed 2009-06-19
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

19242372

DOI: Digital Object Identifier

NIHMS126415

Related Literature

Article Analysis
・Side Effects of metaproterenol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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