Side Effects of metaproterenol: A Synthesis of Findings from 32 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of metaproterenol: A Synthesis of Findings from 32 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Metaproterenol is a medication that works to dilate the bronchi, making it widely used in the treatment of asthma. Research has shown that metaproterenol is effective in improving asthma symptoms by expanding the bronchi. 20 、 30 、 12 、 6 、 1 、 4 、 3 、 22 、 8 、 19 、 31 、 17 、 2 、 13 、 23 、 27 、 14 、 26 、 7 、 25 、 9 、 32 、 10 、 29 、 16 、 5 、 18 、 28 、 11 、 15 、 24 、 21 、 18

Reasons for Side Effects

Metaproterenol acts on beta2-adrenergic receptors, causing the bronchi to expand. These beta2-adrenergic receptors are also present in the heart and blood vessels, so metaproterenol can also act on the heart and blood vessels, causing side effects. 4 、 22 、 17 、 2

Common Side Effects

Tachycardia

Metaproterenol can cause tachycardia because it speeds up the heartbeat. 30 、 1 、 31 、 17 、 6 、 7 、 11 、 21

Tremors

Metaproterenol can cause tremors because it can relax muscles. 30 、 1 、 31 、 17 、 23 、 24 、 21

Shortness of Breath

Metaproterenol can cause temporary shortness of breath as it dilates the bronchi. 20

Headache

Metaproterenol can cause headaches. 20

Nausea

Metaproterenol can cause nausea. 20 、 6

Palpitations

Metaproterenol can cause palpitations. 1 、 11 、 21

Insomnia

Metaproterenol can cause insomnia. 31

Increased Blood Pressure

Metaproterenol can raise blood pressure. 1 、 17 、 6 、 21

Nervousness

Metaproterenol can cause nervousness. 1 、 21

Rash

Metaproterenol can cause rashes. 1

Hypokalemia

Metaproterenol can cause hypokalemia. 22

Side Effects Countermeasures

Tachycardia

If you are concerned about tachycardia, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1

Tremors

If you are concerned about tremors, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1

Shortness of Breath

If you are concerned about shortness of breath, please consult your doctor. They may switch you to a different medication or adjust your dosage. 20

Headache

If you are concerned about headaches, please consult your doctor. They may switch you to a different medication or adjust your dosage. 20

Nausea

If you are concerned about nausea, please consult your doctor. They may switch you to a different medication or adjust your dosage. 20 、 6

Palpitations

If you are concerned about palpitations, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1 、 11 、 21

Insomnia

If you are concerned about insomnia, please consult your doctor. They may switch you to a different medication or adjust your dosage. 31

Increased Blood Pressure

If you are concerned about increased blood pressure, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1 、 17 、 6 、 21

Nervousness

If you are concerned about nervousness, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1 、 21

Rash

If you are concerned about rashes, please consult your doctor. They may switch you to a different medication or adjust your dosage. 1

Hypokalemia

If you are concerned about hypokalemia, please consult your doctor. They may switch you to a different medication or adjust your dosage. 22

Comparison Between Studies

Commonalities Between Studies

Many studies have shown that metaproterenol is effective in improving asthma symptoms. 20 、 30 、 12 、 6 、 1 、 4 、 3 、 22 、 8 、 19 、 31 、 17 、 2 、 13 、 23 、 27 、 14 、 26 、 7 、 25 、 9 、 32 、 10 、 29 、 16 、 5 、 18 、 28 、 11 、 15 、 24 、 21 、 18

Differences Between Studies

Studies have shown that the frequency and severity of side effects can vary depending on the method and dosage of metaproterenol administration. 20 、 1 、 7 、 14 、 26 、 32 、 21

Points to Note Regarding Real-Life Application

Metaproterenol is an effective medication for treating asthma, but side effects can occur. When using metaproterenol, please carefully follow your doctor's instructions and consult with them immediately if you experience any side effects. 30 、 1 、 31 、 17 、 6 、 7 、 11 、 22 、 21

Limitations of Current Research

There is still insufficient research on the side effects of metaproterenol. Further research is needed, particularly on long-term side effects and side effects in specific populations. 22 、 28

Future Research Directions

Further research is needed on the long-term side effects of metaproterenol, as well as side effects in specific populations. Research is also needed on ways to reduce the side effects of metaproterenol. 22 、 28

Conclusion

Metaproterenol is an effective medication for treating asthma, but side effects can occur. When using metaproterenol, please carefully follow your doctor's instructions and consult with them immediately if you experience any side effects. There is still insufficient research on the side effects of metaproterenol. More research is needed on the side effects of metaproterenol in the future.

Keywords
Benefit Keywords
Bronchodilation
1
Neuropathic pain treatment
2
Metastasis prevention
3
Beta-agonist therapy
Cardiovascular safety
4
Asthma treatment
5
Asthma treatment
6
Improved pulmonary function
Longer duration of action
7
FEV1 improvement
8
Acute asthma treatment
9
Treats childhood asthma
10
Effective asthma treatment
Reduced side effects
11
Bronchodilation
12
Asthma treatment
13
Asthma treatment
14
Bronchodilation
15
Bronchodilator efficacy
16
Fast absorption
Negligible side effects
17
Asthma treatment
18
Airflow obstruction treatment
19
Effective bronchodilation
20
Asthma Treatment
21
Bronchodilating potency
Effective bronchodilator
Effective maintenance therapy
Effective treatment for acute attack
High first-pass metabolism
Safe at therapeutic doses
22
Bronchodilation
Long duration of action
23
COPD treatment
24
Asthma treatment
25
Asthma treatment
26
Improved asthma outcome
Prolonged bronchodilation
27
Control exercise-induced asthma
28
Blocked exercise-induced bronchospasm
Improved FEV1/VC
Improved PEFR
Improved wheezing scores
Liquidifying effect on bronchial mucous
29
Bronchodilator
30
Bronchodilation
31
Effective for asthma
Long-acting
32
Risk Keywords
Increased heart rate
Palpitation
Systolic blood pressure
Tremor
1
Beta-agonist toxicity
Cardiodepressive side effects
4
Pulse rate increase
Side effects
6
Chronotropic effects
7
No adverse effects
8
Minimal side effects
12
Nausea
Palpitations
Tremor
14
Minimal side effects
15
Dosage uncertainty
Side effects
16
Exacerbations
18
Side effects
20
Tachycardia
Tremor
21
Side effects at high doses
22
Central nervous system side effects
Musculoskeletal side effects
23
Side effects
24
Cough
Exacerbation of symptoms
25
No major side effects
29
Hypocapnia
Hypoxemia
Tachycardia
30
Side effects
31
Negligible side effects
32
Literature analysis of 32 papers
Positive Content
32
Neutral Content
0
Negative Content
0
Article Type
17
0
0
3
32
1.

Bronchodilator and side effects of different modes of administration of metaproterenol: inhaled, oral, and in combination.

Author: MaguireG P, EmirgilC

Bronchodilation
Increased heart rate
Palpitation
Systolic blood pressure
Tremor

Inhaled and oral metaproterenol were compared in 20 patients with asthma. The combination of inhaled and oral metaproterenol resulted in greater bronchodilation than either route alone. Inhaled metaproterenol had no significant side effects, while oral metaproterenol was associated with a small increase in pulse rate and blood pressure and unpleasant sensations such as tremor and palpitation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

From antidepressant drugs to beta-mimetics: preclinical insights on potential new treatments for neuropathic pain.

Author: BarrotMichel, YalcinIpek, Choucair-JaafarNada, BenbouzidMalika, Freund-MercierMarie-José

Neuropathic pain treatment

This review discusses the potential for beta-mimetics, such as terbutaline and salbutamol, to treat neuropathic pain. Preclinical studies suggest that beta-mimetics may be effective in reducing neuropathic pain, and clinical trials are underway to confirm this.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

CpG-C oligodeoxynucleotides limit the deleterious effects of beta-adrenoceptor stimulation on NK cytotoxicity and metastatic dissemination.

Author: GoldfarbYael, BenishMarganit, RosenneElla, MelamedRivka, LeviBen, GlasnerAriella, Ben-EliyahuShamgar

Metastasis prevention

Suppression of natural killer (NK) cell activity is a common consequence of stress, has been associated with malignant recurrence in cancer patients, and has been shown to underlie metastatic dissemination in animal models. The study examined the prophylactic use of type-C CpG oligodeoxynucleotides (CpG-C ODN) in a pharmacologic stress model using metaproterenol for beta-adrenoceptor stimulation in Fisher 344 rats. The results indicated that the beneficial effects of CpG-C ODN were more pronounced under pharmacologic stress than under baseline conditions. A bolus of CpG-C ODN (330 microg/kg, intraperitoneally) 24 hours before metaproterenol challenge was most effective in reducing lung tumor retention of an experimental syngeneic mammary adenocarcinoma (MADB106) without observable side effects. NK cell depletion revealed their crucial role in improving baseline resistance to metastatic dissemination after CpG-C ODN administration. Assessment of NK cell cytotoxicity in the circulation and marginating-pulmonary immune compartments showed that CpG-C ODN protected individual NK cells from metaproterenol-induced suppression in both compartments. Moreover, in the marginating-pulmonary compartment, CpG-C ODN elevated baseline cytotoxicity per NK cell against MADB106 tumor cells and increased NK cell numbers in nonstressed rats. In conclusion, prophylactic CpG-C ODN treatment can improve immunocompetence and potentially reduce metastatic dissemination, particularly in clinical settings with enhanced sympathetic stress responses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

beta-agonistic bronchodilators: comparison of dose/response in working rat hearts.

Author: ZimmerG, DahintenA, FitznerA, HalbigS, NollT, TreuschF, LibertusH

Beta-agonist therapy
Cardiovascular safety
Beta-agonist toxicity
Cardiodepressive side effects

Fenoterol and terbutaline were found to have cardiodepressive side effects and greater toxicity. Salbutamol and, in particular, reproterol appear much better tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Comparison of two regimens of beta-adrenergics in acute asthma.

Author: McDermottM F, NasrI, RydmanR J, CorderoM, KampeL M, LewisR, PortmanL, WajdaJ, MacugaM, BuckleyR

Asthma treatment

A more aggressive dosing regimen of nebulized metaproterenol was found to be more effective in treating acute asthma exacerbations compared to a less frequent regimen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Efficacy and safety of a rapid-sequence metaproterenol protocol in the treatment of acute adult asthma.

Author: JerrardD A, OlshakerJ, WelebobE, CaraballoV, HooperF

Asthma treatment
Pulse rate increase
Side effects

This study investigated the efficacy and safety of a rapid-sequence nebulized metaproterenol regimen for the treatment of acute asthma in adults. The regimen was found to be effective in reversing bronchospasm, but side effects were of major concern.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Comparison of albuterol and metaproterenol syrup in the treatment of childhood asthma.

Author: WolfeJ D, ShapiroG G, RatnerP H

Improved pulmonary function
Longer duration of action
Chronotropic effects

Albuterol syrup produced a greater peak magnitude of bronchodilation and longer duration of action than metaproterenol syrup in 65 children with mild to moderate asthma. While albuterol had a lower chronotropic effect, both drugs had comparable side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A randomized comparison of atropine and metaproterenol inhalational therapies for refractory status asthmaticus.

Author: YoungG P, FreitasP

FEV1 improvement
No adverse effects

An additional beta-adrenergic inhalation treatment results in greater FEV1 improvement than that resulting from the addition of an atropine inhalation in adults with refractory status asthmaticus.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Nebulized atropine sulfate in the treatment of acute asthma.

Author: OwensM W, GeorgeR B

Acute asthma treatment

Nebulized atropine sulfate provided no additional benefit when added to metaproterenol during the initial treatment of acute asthma attacks in adults.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Metaproterenol (Alupent) metered dose inhaler in children 5-12 years of age.

Author: StormsW W, BiermanC W, ChaiH, DockhornR J, EgglestonP, EllisE F, FeldmanC, FinkJ N, HemstreetM P, KnikerW T

Treats childhood asthma

Metaproterenol sulfate metered dose inhaler was safe and effective in treating asthma in children aged 5 to 12 years. It improved pulmonary function parameters without significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Comparison of aerosolized glycopyrrolate and metaproterenol in acute asthma.

Author: GilmanM J, MeyerL, CarterJ, SlovisC

Effective asthma treatment
Reduced side effects

Nebulized glycopyrrolate, an anticholinergic drug, was found to be as effective as metaproterenol, a beta-agonist, in treating acute asthma. Glycopyrrolate did not cause the tremors, palpitations, and paresthesias associated with metaproterenol, and its effect on heart rate was significantly less than that of metaproterenol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Dose-response relationship of inhaled metaproterenol sulfate in preschool children with mild asthma.

Author: NussbaumE, EyzaguirreM, GalantS P

Bronchodilation
Minimal side effects

Metaproterenol sulfate 5% inhalant solution at a dose of 0.01 mL/kg is effective in treating asthma in preschool children. The drug significantly improved lung function, lasting for up to 3 hours. Side effects were minimal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Comparison of safety and efficacy of inhaled pirbuterol with metaproterenol.

Author: TinkelmanD G, BrandonM L, GriecoM, HudsonL, RosenthalR R, SpectorS L, TashkinD, VotteriB

Asthma treatment

Pirbuterol and metaproterenol are beta-2 selective beta agonists used to treat asthma. This study compared the safety and efficacy of these agents in 133 asthmatic patients for 12 weeks. There were no significant differences in clinical efficacy, onset of action, peak effect, side effects, or development of tolerance between the two agents.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Frequency of inhaled metaproterenol in the treatment of acute asthma exacerbation.

Author: NelsonM S, HofstadterA, ParkerJ, HargisC

Asthma treatment
Nausea
Palpitations
Tremor

Inhaled metaproterenol given frequently during acute asthma exacerbations is safe and effective, leading to improved lung function without increased side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

The inhaled bronchodilators ipratropium bromide and metaproterenol in adults with CF.

Author: WeintraubS J, EschenbacherW L

Bronchodilation
Minimal side effects

Inhaled ipratropium bromide and metaproterenol showed bronchodilatory effects in older patients with cystic fibrosis, with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Assessment of response to oral metaproterenol sulfate by forced oscillation in young children.

Author: MenonP, HilmanB C, MenonV, BairnsfatherL

Bronchodilator efficacy
Dosage uncertainty
Side effects

Oral metaproterenol sulfate (MS) was effective in improving bronchodilator efficacy in asthmatic children aged 3 to 6 years, as objectively assessed by measuring mean total respiratory resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Plasma levels, heart rate, and blood pressure after intravenous, oral, and aerosol administration of reproterol in man.

Author: HagemanR J, de ZeeuwR A, GrevingJ E, KrannJ J, KoëterG H

Fast absorption
Negligible side effects

Reproterol was well-tolerated in healthy volunteers after intravenous infusion, oral, and aerosol administration, with negligible effects on heart rate and blood pressure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Need for theophylline in severe steroid-requiring asthmatics.

Author: BrennerM, BerkowitzR, MarshallN, StrunkR C

Asthma treatment
Exacerbations

Theophylline was found to be beneficial in a subset of severe asthmatics who cannot be controlled with other available medications. Discontinuation of theophylline resulted in increased steroid requirements, decreased spirometry, and severe exacerbations in all five patients studied.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction.

Author: TurnerJ R, CorkeryK J, EckmanD, GelbA M, LipavskyA, SheppardD

Airflow obstruction treatment

The study compared the effectiveness of using a metered dose inhaler (MDI) with a spacer to that of a continuous flow nebulizer for treating acute airflow obstruction in patients with asthma and COPD. The results showed that there was no significant difference in effectiveness between the two methods. Both treatments were equally effective in reducing dyspnea and improving lung function, with no significant difference in side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Dose-related effects of nebulized metaproterenol in asthmatic children.

Author: CrainE F, GershelJ C, KadarA, KastnerT

Effective bronchodilation
Side effects

Inhaled metaproterenol solution (5%) was effective in treating acute bronchospasm in asthmatic children aged 6-12. The study found that a dose of 0.1 ml (5 mg) provided as much bronchodilation as higher doses but with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

[Intravenous infusion of reproterol (a beta-2-mimetic agent) in the therapy of severe asthma attacks in childhood].

Author: HusseinA, von der HardtH, MüllerW, SchellS M

Asthma Treatment
Tachycardia
Tremor

Reproterol infusion is recommended for children with acute severe asthma, especially those who do not respond to current therapy regimen or have previously experienced numerous intubations.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

23.

Comparison of the acute cardiopulmonary effects of oral albuterol, metaproterenol, and terbutaline in asthmatics.

Author: WolfeJ D, YamateM, BiedermannA A, ChuT J

Bronchodilation
Long duration of action
Central nervous system side effects
Musculoskeletal side effects

Oral albuterol and terbutaline were found to be more effective and longer-acting bronchodilators than oral metaproterenol. Albuterol was associated with fewer side effects. The more rapid onset of action of metaproterenol suggests that it may be advantageous for as-needed use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease. A 90-day multi-center study.

Author: TashkinD P, AshutoshK, BleeckerE R, BrittE J, CugellD W, CummiskeyJ M, DeLorenzoL, GilmanM J, GrossG N, GrossN J

COPD treatment
Side effects

Ipratropium bromide was effective in treating chronic obstructive pulmonary disease (COPD). It was more effective than metaproterenol and had fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Use of ipratropium bromide in asthma. Results of a multi-clinic study.

Author: StormsW W, BodmanS F, NathanR A, BusseW W, BushR K, FalliersC J, O'HollarenJ D, WegJ G

Asthma treatment
Cough
Exacerbation of symptoms

Ipratropium bromide and metaproterenol were both effective bronchodilators for patients with asthma. The only significant side effects of ipratropium bromide were cough and exacerbation of symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Use of a tube spacer to improve the efficacy of a metered-dose inhaler in asthmatic children.

Author: RachelefskyG S, RohrA S, WoJ, GraceyV, SpectorS L, SiegelS C, KatzR M, MickeyM R

Asthma treatment

A tube spacer (Aerochamber) did not significantly improve bronchodilation achieved with metaproterenol in 16 asthmatic children. However, the spacer may be helpful for children who have difficulty using a metered-dose inhaler correctly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Aerosolized metaproterenol compared to subcutaneous epinephrine in the emergency treatment of acute childhood asthma.

Author: RuddyR M, KolskiG, ScarpaN, WilmottR

Improved asthma outcome
Prolonged bronchodilation

Aerosolized metaproterenol was as effective as subcutaneous epinephrine in treating acute asthma in children. Metaproterenol was associated with prolonged bronchodilation and fewer treatment failures compared to epinephrine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

The use of anti-asthmatic drugs. Do they affect sports performance?

Author: FitchK D

Control exercise-induced asthma

Several drugs are available to control asthma, including sodium cromoglycate, H1-antagonists, belladonna alkaloids, methyl xanthines, glucocorticoids and beta 2-adrenoceptor stimulants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

29.

Comparative bronchodilatory activity of cetiedil citrate monohydrate, theophylline, orciprenaline and placebo in adult asthmatics.

Author: ChoY W, OhS Y, HanH C, KuemmerleH P

Blocked exercise-induced bronchospasm
Improved FEV1/VC
Improved PEFR
Improved wheezing scores
Liquidifying effect on bronchial mucous
No major side effects

Cetiedil, theophylline, and orciprenaline were all effective in improving wheezing scores in patients with asthma. Cetiedil was the most effective drug in blocking exercise-induced bronchospasm.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer].

Author: BudmigerH, KydK, ScherrerM

Bronchodilator
Hypocapnia
Hypoxemia
Tachycardia

Salbutamol was found to be the most selective beta-stimulator for asthma, followed by fenoterol, terbutaline, and reproterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

31.

Metabolic and cardiovascular effects of carbuterol and metaproterenol.

Author: SandersJ P, PotterD E, EllisS, BeeD E, GrantJ A

Bronchodilation
Side effects

Carbuterol, a selective beta-adrenergic bronchodilator, was well tolerated at a dose of 2 mg in 8 patients with asthma. The higher dose (4 mg) was associated with more frequent side effects, including increases in glucose, insulin, lactate, and free fatty acids. Metaproterenol also caused increases in glucose and insulin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

32.

Sixty day trial of a new inhalant dosage form of metaproterenol.

Author: ChervinskyP

Effective for asthma
Long-acting
Negligible side effects

Metaproterenol was more effective and longer acting than isoproterenol in treating asthma. No tolerance developed to metaproterenol and side effects were negligible.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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