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Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.

Author: AndersonJudy E, BurczynskiFrank J, HasinoffBrian B, LuQilong, WangGuqi, ZhangKaidong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This research developed a new nitric oxide (NO) donor, guaifenesin dinitrate (GDN), which was shown to promote satellite cell activation and proliferation in muscle tissue. This could have potential applications for treating muscle atrophy and promoting repair after injury.
Paper Details　
Original Abstract of the Article :
Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease. Targeting a new drug that specifically delivers NO to muscle has the potential to promote normal function...See full text at original site
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引用元：
https://doi.org/10.1021/mp800226z

データ提供：米国国立医学図書館（NLM）

Unlocking the Potential of Nitric Oxide for Muscle Regeneration

The field of regenerative medicine is constantly seeking innovative ways to repair and restore damaged tissues. This study explores the potential of nitric oxide (NO) as a therapeutic agent for promoting skeletal muscle regeneration. The researchers investigated the effects of NO delivery to muscle cells, focusing on its ability to activate satellite precursor cells, which play a crucial role in muscle growth and repair. Their findings provide exciting insights into the potential of NO as a therapeutic target for treating muscle diseases.

Nitric Oxide: A Key to Muscle Regeneration

The study demonstrates that NO can effectively activate satellite precursor cells, promoting their entry into the cell cycle and contributing to muscle regeneration. The researchers developed a novel NO-releasing analogue of the muscle relaxant guaifenesin, demonstrating its efficacy in stimulating satellite cell activation and proliferation. These findings suggest that NO-based therapies hold promise for treating a range of muscle diseases, including muscular dystrophy and muscle atrophy.

Promoting Muscle Health: A Natural Approach

Just as a camel adapts to the desert environment by building muscle mass, so too can individuals benefit from promoting muscle health. This research suggests that NO-based therapies may provide a natural approach to muscle regeneration, offering hope for patients with muscle disorders. It's important to continue researching and exploring the therapeutic potential of NO for muscle health.

Dr.Camel's Conclusion

This research delves into the fascinating world of muscle regeneration, highlighting the potential of nitric oxide as a therapeutic agent. It's like a camel discovering a hidden oasis in the desert, offering a source of renewal and rejuvenation.

Date :
  1. Date Completed 2009-08-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19317416

DOI: Digital Object Identifier

10.1021/mp800226z

SNS
PICO Info
in preparation
Languages

English

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