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Mixed-effects modeling of the influence of midazolam on propofol pharmacokinetics.

Author: DahanAlbert, LichtenbeltBart Jan, OlofsenErik, VuykJaap, van KleefJack W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Midazolam, a common preoperative sedative, was found to influence the pharmacokinetics of propofol, another anesthetic. The study aimed to identify this influence for optimizing anesthetic regimens.
Paper Details　
Original Abstract of the Article :
The combined administration of anesthetics has been associated with pharmacokinetic interactions that induce concentration changes of up to 30%. Midazolam is often used as a preoperative sedative in advance of a propofol-based anesthetic. In this study, we identified the influence of midazolam on th...See full text at original site
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引用元：
https://doi.org/10.1213/ane.0b013e31819e4058

データ提供：米国国立医学図書館（NLM）

The Influence of Midazolam on Propofol Pharmacokinetics

This research delves into the fascinating world of [anesthesia] and examines the complex interaction between two commonly used drugs: [midazolam] and [propofol]. The study explored the impact of midazolam on the pharmacokinetics of propofol, which involves the absorption, distribution, metabolism, and excretion of the drug in the body.

A Complex Dance of Anesthetics

The study found that the co-administration of midazolam and propofol can lead to significant pharmacokinetic interactions, resulting in notable concentration changes in the body. This finding highlights the importance of careful monitoring and dose adjustments when these drugs are used together.

Understanding Anesthetic Interactions

This research is a reminder that, just as the delicate balance of a desert ecosystem can be disrupted by external factors, the interactions between different anesthetics can have significant effects on the body. Understanding these interactions is essential for ensuring patient safety and optimizing anesthetic outcomes.

Dr.Camel's Conclusion

This research is a reminder that, just as a camel carefully navigates a vast and challenging desert, healthcare providers must carefully consider the interactions between different medications to ensure the safety and well-being of their patients.
Date :
  1. Date Completed 2009-04-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19372331

DOI: Digital Object Identifier

10.1213/ane.0b013e31819e4058

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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