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Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats.

Author: AhnByoung Ok, ChoiSeul Min, KangKyung Koo, KimJeong Hoon, SeoMi Jeong, YooMoohi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Combining amlodipine and losartan, both effective antihypertensive drugs, was found to be more effective in lowering blood pressure and improving arterial endothelium-dependent relaxation than monotherapy in spontaneously hypertensive rats, suggesting potential benefits for hypertension treatment.
Paper Details　
Original Abstract of the Article :
A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current and effective antihypertensive drugs, this study...See full text at original site
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引用元：
https://doi.org/10.1007/s12272-009-1307-x

データ提供：米国国立医学図書館（NLM）

Amlodipine and Losartan: A Synergistic Approach to Lower Blood Pressure

This research delves into the field of hypertension treatment, exploring the potential benefits of combining two different classes of blood pressure-lowering medications: calcium channel blockers (CCBs) and angiotensin II receptor type-1 blockers (ARBs). The researchers investigated the synergistic effects of amlodipine, a CCB, and losartan, an ARB, on blood pressure in spontaneously hypertensive rats. This study provides valuable insights into the potential for combining different drug classes to achieve better blood pressure control and improve patient outcomes.

A Powerful Duo: Amlodipine and Losartan in Harmony

The study found that combining amlodipine and losartan resulted in a greater reduction in blood pressure than either drug alone. This suggests that the two drugs work synergistically, enhancing each other's effects and improving blood pressure control. The study also showed that the combination therapy was associated with improvements in arterial endothelium-dependent relaxation, a critical factor in cardiovascular health.

Optimizing Blood Pressure Control: A Multifaceted Approach

This research highlights the potential benefits of combining different drug classes in hypertension treatment. By considering the synergistic effects of medications, healthcare professionals can develop more effective and personalized treatment plans, improving blood pressure control and reducing the risk of cardiovascular complications.

Dr. Camel's Conclusion

Imagine a camel caravan crossing a vast desert, facing the scorching sun and treacherous terrain. Just like the camels need a strong team and a balanced approach to navigate the challenges, hypertension treatment requires a multifaceted approach. This study demonstrates the powerful synergy between amlodipine and losartan, offering a valuable tool for healthcare professionals to effectively manage blood pressure and improve patient outcomes.
Date :
  1. Date Completed 2009-05-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19387578

DOI: Digital Object Identifier

10.1007/s12272-009-1307-x

Related Literature

Article Analysis
・Side Effects of losartan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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