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Comparing the effects of atamestane, toremifene and tamoxifen alone and in combination, on bone, serum lipids and uterus in ovariectomized rats.

Author: GossPaul E, HuHaiqing, QiShangle

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Atamestane, a steroidal aromatase inhibitor, combined with tamoxifen or toremifene, showed similar effects on bone, lipid metabolism, and the endometrium compared to the anti-estrogens alone.
Paper Details　
Original Abstract of the Article :
Complete estrogen blockade remains under investigation as a means to optimize anti-estrogen therapy in breast cancer thus both the efficacy and end-organ toxicities are of interest with combinations. We hypothesized that a steroidal aromatase inhibitor (AI) atamestane (ATA) alone, and in combination...See full text at original site
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引用元：
https://doi.org/10.1016/j.jsbmb.2009.01.005

データ提供：米国国立医学図書館（NLM）

Hormonal Harmony: Finding the Right Balance in Breast Cancer Treatment

This research explores the intricate interplay of estrogen and breast cancer treatment. The study investigates the effects of various anti-estrogen therapies on bone, lipid metabolism, and the endometrium. Estrogen, like a desert bloom, plays a crucial role in the body's delicate balance, and its influence on breast cancer treatment is like a winding sandstorm, requiring careful navigation.

Aramestane: A Potent Oasis in the Desert of Breast Cancer Treatment

The study shows that aramestane (ATA), a steroidal aromatase inhibitor, demonstrates positive effects on bone health and lipid metabolism. ATA is like a steady stream in the desert, offering a sustained and beneficial effect. The research also reveals that ATA, when combined with tamoxifen (TAM) or toremifene (TOR), does not amplify the effects of these anti-estrogens, but instead, the combination offers a comparable outcome. This finding is like discovering a hidden oasis, offering a potent but balanced approach to breast cancer treatment.

Understanding the Complexity of Treatment: A Holistic Approach

The study emphasizes the importance of a holistic approach to breast cancer treatment. Just as the desert requires a multi-faceted understanding for survival, so too does breast cancer treatment. By considering the impact of treatment on various organ systems, researchers are paving the way for more comprehensive and effective treatment strategies.

Dr.Camel's Conclusion

This research highlights the complex interplay between estrogen and breast cancer treatment. The study offers insights into the effectiveness of different anti-estrogen therapies, emphasizing the importance of personalized treatment strategies. The discovery of aramestane's potential as a potent and balanced option for breast cancer treatment provides a valuable oasis in the desert of this complex disease.

Date :
  1. Date Completed 2009-06-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19429427

DOI: Digital Object Identifier

10.1016/j.jsbmb.2009.01.005

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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