Paper Details

  1. Home
  2. Paper Details

Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect.

Author: FlanaganSarah E, GreeleySiri Atma W, HattersleyAndrew T, KumaraguruJanani, NuboerRoos, PhilipsonLouis H, Rubio-CabezasOscar, StøyJulie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tooth discoloration was observed in 5 out of 67 patients who were successfully transferred from insulin injections to oral sulfonylureas for the treatment of neonatal diabetes. The discoloration was only seen in patients taking glibenclamide (glyburide) and ranged from mild staining to loss of enamel. This previously unreported side effect requires further investigation, but should not preclude the use of sulfonylureas in patients with activating KCNJ11 mutations.
Paper Details　
Original Abstract of the Article :
OBJECTIVE To assess if tooth discoloration is a novel side effect of sulfonylurea therapy in patients with permanent neonatal diabetes due to mutations in KCNJ11. RESEARCH DESIGN AND METHODS A total of 67 patients with a known KCNJ11 mutation who had been successfully transferred from insulin inject...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713626/

データ提供：米国国立医学図書館（NLM）

Tooth Discoloration: A Potential Side Effect of Glibenclamide

Neonatal diabetes, a rare form of diabetes diagnosed in infancy, often requires medication to regulate blood sugar levels. One common treatment is glibenclamide, a medication that belongs to the sulfonylurea class. This study investigates a potential side effect of glibenclamide, namely tooth discoloration, in patients with neonatal diabetes.

Glibenclamide and Tooth Discoloration

The study examined 67 patients with neonatal diabetes who had been successfully transferred from insulin injections to glibenclamide. Researchers found that 5 of these patients experienced altered tooth appearance, ranging from mild discoloration to enamel loss. This observation suggests that glibenclamide, while effective in controlling blood sugar, might pose a risk of tooth discoloration, particularly in children who frequently chew the tablets or take it in a concentrated solution.

Monitoring and Management of Side Effects

This research highlights the importance of careful monitoring for potential side effects, even when a medication is generally considered safe and effective. Just as a camel needs to be vigilant for potential dangers in the desert, healthcare providers should be attentive to any changes in a patient's condition, especially in developing children. While the benefits of glibenclamide treatment are undeniable, the potential for tooth discoloration should be considered and managed appropriately.

Dr. Camel's Conclusion

This study adds a new layer of complexity to the understanding of glibenclamide's side effects. While tooth discoloration appears to be a rare occurrence, it underscores the importance of careful monitoring and communication between patients and healthcare providers. By being vigilant and addressing potential issues promptly, we can ensure that medication therapies remain safe and effective, allowing patients to thrive.

Date :
  1. Date Completed 2009-10-26
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19435956

DOI: Digital Object Identifier

PMC2713626

Related Literature

Article Analysis
・Side Effects of glyburide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.