Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center.

Author: AkeJulie, HartzellJoshua D, HowardRobin, NeffRobert, OlsonStephen, PaolinoKristopher, VishnepolskyMark, WeintrobAmy, WortmannGlenn

Paper Details 
Original Abstract of the Article :
The incidence of acute renal failure, defined by the risk, injury, or failure criteria of the RIFLE criteria (risk, injury, failure, loss, and end-stage kidney disease), in 66 patients who received colistimethate sodium was 45%, and 21% of patients stopped therapy because of nephrotoxicity. The RIFL...See full text at original site
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引用元:
https://doi.org/10.1086/599225

データ提供:米国国立医学図書館(NLM)

Colistimethate Sodium: A Powerful Antibiotic with a Potential Side Effect

The battle against bacterial infections is an ongoing quest, with researchers constantly seeking new weapons to combat these microscopic adversaries. This study explores the efficacy and safety of colistimethate sodium, a potent antibiotic, in a real-world setting. The researchers embarked on a journey through the medical landscape, seeking to understand the impact of colistimethate sodium on patients battling serious infections.

The researchers found that colistimethate sodium effectively battled bacterial infections but also observed a concerning trend: a significant percentage of patients developed acute renal failure. This finding underscores the need for careful monitoring and management of colistimethate sodium therapy to minimize the risk of kidney damage. The researchers also highlighted the importance of using standardized criteria to assess nephrotoxicity, ensuring consistency and comparability across studies.

Navigating the Risks and Benefits of Colistimethate Sodium

This study highlights the need for a balanced approach when prescribing colistimethate sodium. While this antibiotic can be a potent weapon against serious bacterial infections, it comes with a potential risk of kidney damage. The researchers' observations underscore the importance of careful monitoring and judicious use of this powerful drug.

Kidney Health and Antibiotic Use

This study serves as a reminder that antibiotics, while essential for treating bacterial infections, are not without risks. The researchers' findings highlight the importance of understanding the potential side effects of antibiotics and the need for careful monitoring to minimize these risks. By weighing the potential benefits and risks, we can make informed decisions about antibiotic use and protect our overall health.

Dr.Camel's Conclusion

The use of colistimethate sodium is like navigating a treacherous desert. It offers a powerful weapon against bacterial infections, but it also comes with the potential risk of kidney damage, a threat as formidable as a sandstorm. By being mindful of this potential hazard and following careful monitoring, we can safely navigate this desert and achieve the best possible outcomes.

Date :
  1. Date Completed 2009-06-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19438394

DOI: Digital Object Identifier

10.1086/599225

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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