Effects of colistimethate injection: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major findings

Several studies have shown that colistimethate injection can be an effective treatment for infections caused by multidrug-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 For example, colistimethate injection has been shown to be effective in treating infections such as pneumonia, sepsis, meningitis, wound infections, and prosthetic joint infections. 12 7 16 5 2 18 One study even showed that colistimethate sodium administered into the cerebrospinal fluid (CSF) was effective in treating central nervous system infections caused by pan-resistant Gram-negative bacteria, even though the doses and daily regimens are often chosen empirically and the CSF pharmacokinetics of colistin after intraventricular administration of CMS had not been characterized before. 10 This is especially important in cases where other antibiotics have failed. 12 Colistimethate can be administered through various methods, including intravenous injection, intramuscular injection, inhalation, and intrathecal injection. 12 1 The dosage of colistimethate varies depending on factors such as age, weight, kidney function, and the type of infection. 7 For optimal effectiveness, it is important to administer the appropriate dosage for the appropriate duration. 15 If you experience any side effects during colistimethate treatment, it is essential to consult your doctor immediately.

Benefits and risks

Benefit summary

Colistimethate injection can be an effective treatment for infections caused by multidrug-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 It can be effective even when other antibiotics have failed. 12 It is used to treat various types of infections. 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 It is available in various administration methods. 12 、 1

Risk summary

Colistimethate injection can cause side effects, such as kidney damage. 16 、 18 It may also cause neurotoxicity. 10 The dosage of colistimethate varies depending on factors such as age, weight, kidney function, and the type of infection. 7 It is important to use colistimethate injection under the guidance of a doctor.

Comparison of studies

Commonalities among studies

Several studies have shown that colistimethate injection can be an effective treatment for infections caused by multidrug-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 In many studies, it was found that the dosage of colistimethate varies depending on factors such as age, weight, kidney function, and the type of infection. 7

Differences among studies

Colistimethate is available in various administration methods. 12 、 1 The effectiveness and side effect rates of colistimethate can vary depending on the study, which may be due to differences in the study population and research design. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18

Consistency and inconsistencies of findings

Multiple studies have shown that colistimethate is effective against infections caused by multidrug-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 However, it is important to note that colistimethate can cause kidney toxicity. 16 、 18 The dosage of colistimethate varies depending on factors such as age, weight, kidney function, and the type of infection, so it is important to use colistimethate under the guidance of a doctor. 7

Precautions for real-life applications

Colistimethate injection can be a valuable treatment option for infections caused by multidrug-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 However, it is crucial to use colistimethate injection under the guidance of a doctor because of its potential for kidney toxicity. 16 、 18 The dosage of colistimethate varies depending on factors such as age, weight, kidney function, and the type of infection, so it is important to use colistimethate under the guidance of a doctor. 7

Limitations of current research

Research on colistimethate injection is still inadequate. 12 、 7 Specifically, there is a shortage of research on the long-term effects of colistimethate. 12 、 7 Furthermore, research on the dosage and administration methods of colistimethate is also insufficient. 7

Directions for future research

Research on the long-term effects of colistimethate is needed, as well as research on the dosage and administration methods of colistimethate. 12 、 7 Research is also necessary to suppress the emergence of colistimethate-resistant bacteria. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18

Conclusion

Colistimethate injection can be a valuable treatment option for infections caused by multidrug-resistant bacteria, but its use should be guided by a doctor due to its potential for kidney toxicity. 10 、 14 、 12 、 15 、、 1 、 9 、 11 、 7 、 16 、 5 、 20 、 19 、 3 、 17 、 6 、 2 、 18 Further research is needed on the long-term effects of colistimethate and on the proper dosage and administration methods. 12 、 7

Literature analysis of 20 papers
Positive Content
16
Neutral Content
2
Negative Content
2
Article Type
0
1
2
2
20
3.

Safety and effectiveness of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) against P. aeruginosa: in vitro and in vivo studies following pulmonary and intramuscular administration.

Author: PastorMarta, BasasJana, VairoClaudia, GainzaGarazi, Moreno-SastreMaría, GomisXavier, FleischerAarne, PalominoEsther, BachillerDaniel, GutiérrezFrancisco Borja, AguirreJose Javier, EsquisabelAmaia, IgartuaManoli, GainzaEusebio, HernandezRosa Maria, GavaldàJoan, PedrazJosé Luis

Multiresistant P. aeruginosa treatment
Respiratory infections

Sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) were effective against multiresistant P. aeruginosa (Mr-Pa) respiratory infections in vivo, with low toxicity and efficient distribution to the lung and liver after pulmonary or intramuscular administrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The 21st-century challenge to neurocritical care: the rise of the superbug Acinetobacter baumannii. A meta-analysis of the role of intrathecal or intraventricular antimicrobial therapy in reduction of mortality.

Author: MohammedNasser, SavardekarAmey R, PatraDevi Prasad, NarayanVinayak, NandaAnil

Reduced mortality

Intrathecal or intraventricular administration of antibiotics, in combination with intravenous therapy, was found to significantly reduce mortality in patients with neurosurgical infections caused by multidrug-resistant Acinetobacter baumannii. This finding suggests a potential treatment strategy for this challenging type of infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

7.

Systematic review of the evidence for rational dosing of colistin.

Author: KiftE Visser, MaartensG, BamfordC

Drug resistance

This article highlights the importance of appropriate dosing for colistin, a last-line antibiotic against multidrug-resistant Gram-negative bacteria. Dosing regimens vary widely, emphasizing the need to avoid under-dosing to limit the development of resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Pharmacokinetics of colistin in critically ill patients with multidrug-resistant Gram-negative bacilli infection.

Author: KarnikNiteen D, SridharanKannan, JadhavSonali P, KadamPrashant P, NaiduRaghu K, NamjoshiRahul D, GuptaVishal, GoreMangesh S, SurasePallavi V, MehtaPreeti R, GogtayJaideep A, ThatteUrmila M, GogtayNithya J

Effective treatment
Nephrotoxicity
Neurotoxicity

The aim of our study was to study the single-dose and steady-state pharmacokinetics of colistin in patients with multidrug-resistant Gram-negative bacilli infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Population pharmacokinetic analysis of colistin in burn patients.

Author: LeeJongtae, HanSeunghoon, JeonSangil, HongTaegon, SongWonkeun, WooHeungjeong, YimDong-Seok

Nosocomial infection treatment

A population pharmacokinetic (PK) model for colistin was developed to guide dosing in burn patients. Colistin elimination half-life was shorter in burn patients compared to critically ill patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate.

Author: ImbertiRoberto, CusatoMaria, AccettaGiovanni, MarinòValeria, ProcaccioFrancesco, Del GaudioAlfredo, IottiGiorgio A, RegazziMario

CNS infection treatment
Microbiological cure
Variable CSF efflux

Intraventricular colistin methanesulfonate (CMS) at doses of ≥5.22 mg/day was effective in treating central nervous system infections caused by panresistant Gram-negative bacteria.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Economic effects of an eradication protocol for first appearance of Pseudomonas aeruginosa in cystic fibrosis patients: 1995 vs. 2009.

Author: LillquistYolanda P, ChoEva, DavidsonA George F

Antibiotic therapy
Cystic fibrosis

An early eradication protocol for Pseudomonas aeruginosa (Psa) infection in patients with cystic fibrosis (CF) was associated with economic benefits after 15 years, as reflected in reduced hospitalization and antibiotic usage.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Multidrug-resistant Gram-negative infections: the use of colistin.

Author: MichalopoulosArgyris S, KaratzaDimitra C

Effective against multidrug-resistant bacteria
Safe for most patients
Nephrotoxicity

Colistin is effective and safe in treating multidrug-resistant Gram-negative bacteria infections, with nephrotoxicity reported at 20% or lower. Further research is needed to determine the appropriate dose and compare different administration routes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa.

Author: LuQin, GirardiCassio, ZhangMao, BouhemadBelaïd, LouchahiKamel, PetitjeanOlivier, WalletFrédéric, BecqueminMarie-Helene, Le NaourGilles, MarquetteCharles-Hugo, RoubyJean-Jacques

Treatment of resistant P. aeruginosa

This study compares the lung tissue deposition and antibacterial efficiency of nebulized and intravenous administration of colistin in piglets with pneumonia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center.

Author: HartzellJoshua D, NeffRobert, AkeJulie, HowardRobin, OlsonStephen, PaolinoKristopher, VishnepolskyMark, WeintrobAmy, WortmannGlenn

Acute renal failure

Colistimethate sodium is associated with acute renal failure in 45% of patients, with 21% discontinuing therapy due to nephrotoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Intravenous colistimethate (colistin) use in critically ill children without cystic fibrosis.

Author: FalagasMatthew E, SideriGeorgia, VouloumanouEvridiki K, PapadatosJohn H, KafetzisDimitris A

Infection improvement
Death
No nephrotoxicity

Colistimethate may be a promising treatment option for infections caused by multidrug-resistant Gram-negative bacteria in critically ill pediatric patients, showing improvement in infections and no evidence of nephrotoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Nephrotoxicity of intravenous colistin: a prospective evaluation.

Author: FalagasMatthew E, FragoulisKonstantinos N, KasiakouSofia K, SermaidisGeorge J, MichalopoulosArgyris

Gram-negative infection treatment
Kidney toxicity

Three patients (14.3%) developed nephrotoxicity during treatment with CMS.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Intramuscular injection-site complications.

Author: GreenblattD J, AllenM D

Injection site complications

Intramuscular (IM) injections were found to be a relatively safe procedure, with local complications reported in only 0.4% of recipients. However, certain drugs, such as cephalothin, have a higher incidence of injection-site complications, requiring careful consideration of alternative routes of administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

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