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Etodolac/cyclodextrin formulations: physicochemical characterization and in vivo pharmacological studies.

Author: CalignanoAntonio, CappelloBrunella, IervolinoMaria, MiroAgnese, di MaioClelia

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Formulating etodolac with cyclodextrins improved its physicochemical and pharmacological properties, increasing drug solubility, dissolution rate, and gastric tolerance. HP-beta-CD was the most effective partner for etodolac, showing the highest drug solubilization.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The formulation of nonsteroidal anti-inflammatory drugs with cyclodextrins (CDs) has demonstrated to be a suitable strategy to increase drug aqueous solubility, dissolution rate, and gastric tolerance. AIM: We investigated the effects of the CDs on the physicochemical and pharmacologica...See full text at original site
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引用元：
https://doi.org/10.1080/03639040802680263

データ提供：米国国立医学図書館（NLM）

Etodolac/Cyclodextrin Formulations: A Path to Improved Drug Delivery

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain and inflammation. However, some NSAIDs, such as etodolac, have poor water solubility, limiting their effectiveness and increasing the risk of side effects. This study investigated the potential of cyclodextrins (CDs) to improve the physicochemical and pharmacological properties of etodolac.

Cyclodextrins Enhance Etodolac's Properties

The study found that CDs effectively complexed with etodolac, increasing its solubility and dissolution rate. This led to improved analgesic activity and reduced gastrolesivity (damage to the stomach lining) in vivo. These findings suggest that cyclodextrin formulations may offer a way to improve the delivery and effectiveness of etodolac, while potentially reducing side effects.

Cyclodextrins: A Desert Oasis for Drug Delivery

This study reveals the potential of cyclodextrins to overcome the challenges of delivering etodolac, an NSAID with poor water solubility. It's like finding a refreshing oasis in the desert of drug delivery, providing a way to improve the effectiveness and safety of this important medication. This research holds promise for improving the lives of patients who rely on NSAIDs.

Dr.Camel's Conclusion

This research demonstrates the potential of cyclodextrin formulations to enhance the properties of etodolac, a nonsteroidal anti-inflammatory drug with poor water solubility. The findings suggest that these formulations could improve the delivery and effectiveness of etodolac, potentially leading to reduced side effects. It's like discovering a hidden oasis in the desert of drug delivery, providing a path to improved treatment for patients with pain and inflammation.

Date :
  1. Date Completed 2011-02-17
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

19466892

DOI: Digital Object Identifier

10.1080/03639040802680263

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SNS
PICO Info
in preparation
Languages

English

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