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Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide.

Author: BetzA J, CorreaM, FontL, SagerT N, SalamoneJ D, SinkK S, ValentaJ, VontellR, WordenL

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigates the effects of the selective adenosine A(2A) antagonist KW 6002 on the motor and cellular effects of subchronic administration of the typical antipsychotic pimozide, which is known to produce parkinsonian motor effects. KW 6002 significantly reduces tremulous jaw movements induced by pimozide, suggesting that adenosine A(2A) antagonism may be a therapeutic target for parkinsonian symptoms.
Paper Details　
Original Abstract of the Article :
Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to produce parkinsonian motor effects such as akinesia and tremor. Furthermore, there is an antagonistic interaction between adenosine A(2A) and dopamine D(2) receptors in the basal ganglia, which is important for motor...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuroscience.2009.05.040

データ提供：米国国立医学図書館（NLM）

Investigating the Effects of Adenosine A2A Antagonism on Pimozide-Induced Tremor

The field of neurology is constantly seeking to understand the complexities of movement disorders, particularly those related to typical antipsychotic medications. Pimozide, a typical antipsychotic, is known to induce parkinsonian motor effects, such as tremor. This study, exploring the mechanisms of movement disorders, investigates the effects of an adenosine A2A antagonist, KW 6002, on pimozide-induced oral tremor and striatal c-Fos expression.

Adenosine A2A Antagonism and Striatal Activity

The study, conducted using animal models, demonstrates that KW 6002 significantly reduces pimozide-induced tremulous jaw movements and alters striatal c-Fos expression, a marker of striatal cell activity. The study highlights the potential of adenosine A2A antagonism as a strategy for mitigating the motor side effects of typical antipsychotics. It suggests that targeting adenosine A2A receptors may offer a novel approach to managing parkinsonian symptoms induced by these medications.

The Importance of Understanding Movement Disorders

This research provides valuable insights into the neurobiological mechanisms underlying movement disorders induced by antipsychotic medications. It underscores the importance of continued research to develop targeted therapies that effectively manage these side effects while preserving the therapeutic benefits of these medications.

Dr.Camel's Conclusion

Think of it like a camel navigating a shifting desert landscape. Just as a camel needs to adjust its stride to navigate a bumpy terrain, the brain's intricate network of neurons must work in harmony to produce smooth and coordinated movements. This research sheds light on the role of adenosine A2A receptors in maintaining motor control and suggests that targeting these receptors may offer a path to smoother journeys for individuals experiencing movement disorders related to antipsychotic medications.

Date :
  1. Date Completed 2009-12-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

19467297

DOI: Digital Object Identifier

10.1016/j.neuroscience.2009.05.040

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in preparation
Languages

English

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