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Diphenhydramine as a topical ocular anesthetic.

Author: HarperRichard A, LandesReid D, SuffridgePhillip J, WigginsMichael N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

5% diphenhydramine solution topically applied to rabbit corneas demonstrated significant anesthetic effect compared with salt solution. It may be a safe alternative to topical anesthetics for patients with multiple allergies. Further studies are needed to determine a dose-response curve and evaluate corneal toxicity.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine whether 5% diphenhydramine solution has an anesthetic effect when administered topically to rabbit corneas. DESIGN: Experimental study. PARTICIPANTS: Twenty white New Zealand rabbits. METHODS: Twenty rabbits at the University of Arkansas for Medical Sciences received 1 dro...See full text at original site
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引用元：
https://doi.org/10.3129/i09-004

データ提供：米国国立医学図書館（NLM）

Diphenhydramine: A Potential Oasis for Topical Ocular Anesthesia

The desert of ocular anesthesia is often a challenging landscape, with limited options for patients with multiple allergies. This experimental study investigated the anesthetic effects of diphenhydramine, a commonly used antihistamine, when applied topically to rabbit corneas. The researchers compared the corneal sensation in rabbits treated with 5% diphenhydramine solution to those treated with a control solution. The results showed that diphenhydramine had a significant anesthetic effect, suggesting its potential as a safe alternative for patients with multiple allergies.

Diphenhydramine's Anesthetic Potential: A New Oasis in the Desert of Ocular Anesthesia

This study reveals the potential of diphenhydramine as a topical ocular anesthetic, offering a valuable alternative for patients with allergies to traditional anesthetic agents. While further research is needed to confirm its safety and efficacy in humans, these findings offer a glimmer of hope for patients seeking relief from ocular pain and discomfort. The research on diphenhydramine is like discovering a new oasis in the desert of ocular anesthesia, offering a potentially safer and more effective solution for patients with multiple allergies.

Finding a Path: Ocular Anesthesia for Patients with Allergies

The desert of ocular anesthesia can be a difficult landscape to navigate for patients with allergies. This research on diphenhydramine offers a potential new path towards effective and safe anesthesia. While further studies are needed to confirm its benefits and establish its appropriate use, it offers a promising direction for those seeking alternative solutions.

Dr. Camel's Conclusion

This research on diphenhydramine as a topical ocular anesthetic is like finding a hidden spring in the desert, offering a potential source of relief for patients with allergies. While more research is needed to confirm its safety and efficacy, it's a promising discovery that could help provide better pain management options for individuals with limited choices.

Date :
  1. Date Completed 2009-07-30
  2. Date Revised 2016-10-13
Further Info :

Pubmed ID

19491952

DOI: Digital Object Identifier

10.3129/i09-004

Related Literature

Article Analysis
・Effects of diphenhydramine topical
SNS
PICO Info
in preparation
Languages

English

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