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Developments of indoles as anti-HIV-1 inhibitors.

Author: LvMin, XuHui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the synthesis and anti-HIV-1 activity of indole derivatives, a promising class of HIV-1 inhibitors. The review also discusses the structure-activity relationship (SAR) for some derivatives, paving the way for the design of new indole derivatives as anti-HIV-1 drugs.
Paper Details　
Original Abstract of the Article :
Since the first case of acquired immunodeficiency syndrome (AIDS) was reported in 1981, AIDS has always been a global health threat and the leading cause of deaths due to the rapid emergence of drug-resistance and unwanted metabolic side effects. Every day in 2007 an estimated 6850 people were newly...See full text at original site
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引用元：
https://doi.org/10.2174/138161209788489168

データ提供：米国国立医学図書館（NLM）

Indoles: A Promising Oasis in the Desert of Anti-HIV-1 Inhibitors

The search for effective anti-HIV-1 inhibitors is a continuous journey, much like a camel traversing a vast desert, seeking a life-sustaining oasis. This review explores the potential of indole derivatives as a promising class of anti-HIV-1 inhibitors. The authors highlight the historical development of indole-based drugs, their promising activities against HIV-1, and the structure-activity relationships that guide the design of new and improved inhibitors. This review provides a comprehensive overview of this promising field, offering hope for the development of new and effective treatments for HIV-1 infection.

Indole Derivatives: A Promising Oasis in the Desert of Anti-HIV-1 Drug Development

This review provides a comprehensive and insightful analysis of the potential of indole derivatives as anti-HIV-1 inhibitors. The authors highlight the structural features that contribute to their activity, paving the way for the development of new and more effective drugs. This research underscores the ongoing need for innovation in the fight against HIV-1 infection, highlighting the importance of exploring diverse chemical scaffolds and optimizing drug design.

A Camel's Takeaway: The Importance of Continued Research and Development in the Fight Against HIV-1

The desert of HIV-1 research is vast and ever-changing, but this review provides a valuable oasis of knowledge. The authors highlight the potential of indole derivatives as a promising class of anti-HIV-1 inhibitors, offering hope for the development of new and effective treatments for this devastating disease. This research underscores the importance of continued research and development in the fight against HIV-1 infection.

Dr.Camel's Conclusion

This review explores the potential of indole derivatives as a promising class of anti-HIV-1 inhibitors. The authors highlight the historical development of indole-based drugs, their promising activities against HIV-1, and the structure-activity relationships that guide the design of new and improved inhibitors. This review provides a comprehensive overview of this promising field, offering hope for the development of new and effective treatments for HIV-1 infection.

Date :
  1. Date Completed 2009-09-10
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

19519449

DOI: Digital Object Identifier

10.2174/138161209788489168

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English

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