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Can the response to interferon treatment be predicted in patients with chronic active hepatitis C?

Author: BateyR G, BilousM, CraigP I, FarrellG C, GriersonJ, LinR, McDonaldJ A, SchoemanM N

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effectiveness of interferon-alpha 2b treatment for chronic hepatitis C in 21 patients. Interferon resulted in a significant improvement in liver function, with 64% of patients experiencing a return to normal liver enzyme levels during treatment compared to only 6% of untreated patients. Patients who responded to interferon were more likely to have contracted hepatitis C through intravenous drug use and to have less severe liver disease. Sustained remission after stopping treatment was more common in patients who responded well during treatment. These findings suggest that interferon-alpha 2b may be a beneficial treatment for chronic hepatitis C, particularly in patients with less severe liver disease.
Paper Details　
Original Abstract of the Article :
Twenty-one of 40 patients with chronic non-A, non-B hepatitis (37 anti-HCV positive) were randomised to receive interferon alpha 2b (3 million units subcutaneously thrice weekly for 24 weeks) and then to be observed for six months. Among the other 19 patients (controls) randomised to be observed wit...See full text at original site
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引用元：
https://doi.org/10.1111/j.1445-5994.1991.tb04715.x

データ提供：米国国立医学図書館（NLM）

Predicting Response to Interferon Treatment for Hepatitis C

This study investigates the factors that predict response to interferon treatment in patients with chronic active hepatitis C. It's like searching for clues in a desert landscape, trying to understand the complex interactions that influence disease progression and treatment outcomes. The study found that patients who responded to interferon treatment were more likely to have acquired infection through intravenous drug abuse than blood transfusion and had less severe liver disease. It's like finding a hidden spring that indicates a more favorable path through the desert. The study also highlights the importance of considering individual factors, such as the severity of liver disease, in predicting treatment response. It's like recognizing the unique terrain of each traveler's journey through the desert.

Understanding the Factors that Influence Treatment Response

This study sheds light on the factors that influence treatment response in patients with chronic active hepatitis C. The study's findings underscore the importance of considering individual characteristics, such as the mode of infection and severity of liver disease, in determining treatment strategies. It's like understanding the unique challenges and opportunities presented by different desert environments, allowing us to adapt our approach accordingly.

The Importance of Individualized Treatment

This study emphasizes the importance of individualized treatment approaches for patients with chronic active hepatitis C. It's like tailoring a journey through the desert to the specific needs and conditions of each traveler. By considering individual factors, we can develop more effective and personalized treatment plans for patients with this complex disease.

Dr.Camel's Conclusion

This study provides valuable insights into the factors that predict response to interferon treatment for chronic active hepatitis C. It's like discovering a map that guides us through the complexities of this disease, helping us to understand the terrain and navigate the best path to recovery. The findings underscore the importance of individualized treatment approaches and the need for further research to develop more effective therapies for patients with hepatitis C.

Date :
  1. Date Completed 1991-11-27
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1953524

DOI: Digital Object Identifier

10.1111/j.1445-5994.1991.tb04715.x

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・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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