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Thrombin formation and platelet activation at the site of vascular injury in patients with coronary artery disease treated with clopidogrel combined with aspirin.

Author: BranickaAgnieszka, StepieńEwa, TraczWiesława, UndasAnetta, WołkowPaweł, ZmudkaKrzysztof

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Clopidogrel combined with aspirin did not reduce thrombin formation following vascular injury, but it attenuated platelet soluble CD40 ligand (sCD40L) and P-selectin release. Patients with previous myocardial infarction and peripheral arterial disease had the highest amounts of sCD40L and P-selectin released at baseline.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Data on the effects of oral antiplatelet agents on blood coagulation in vivo are conflicting. The platelet glycoprotein (GP) IIIa PlA2 allele has been suggested to modulate antithrombotic actions of clopidogrel. AIM: We investigated whether clopidogrel combined with aspirin affects loca...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19618315

データ提供：米国国立医学図書館（NLM）

Clopidogrel and Aspirin: A Camel's Journey Through the Desert of Blood Coagulation

This study investigates the effects of combining clopidogrel and aspirin, two commonly used antiplatelet medications, on thrombin formation and platelet activation in patients with coronary artery disease. Imagine a camel, its heart weary from navigating a treacherous desert, seeking relief from the potential dangers of blood clots. This research explores how these medications work together to reduce the risk of heart attacks and strokes.

Clopidogrel and Aspirin: A Protective Oasis in the Desert of Blood Clots

The study reveals that while clopidogrel and aspirin do not significantly reduce thrombin formation, they effectively reduce platelet activation, a crucial step in the formation of blood clots. This research highlights the importance of combining these medications in patients with coronary artery disease, offering a protective oasis in the desert of blood clots.

Navigating the Desert of Cardiovascular Health

Coronary artery disease, like a vast and unforgiving desert, can pose a significant threat to cardiovascular health. This study reminds us of the importance of medication adherence and the need for personalized approaches to managing this complex condition.

Dr. Camel's Conclusion

This study delves into the complex world of blood coagulation, revealing the synergistic effects of clopidogrel and aspirin in reducing the risk of blood clots. Just as a camel relies on its strength and resilience to traverse the desert, patients with coronary artery disease can benefit from a combination of medications and a proactive approach to managing their health.
Date :
  1. Date Completed 2009-10-28
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19618315

DOI: Digital Object Identifier

12618

Related Literature

Article Analysis
・Effects of clopidogrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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