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Safety of intravenous infusion of doripenem.

Author: FileThomas M, RedmanRebecca

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Doripenem, a new carbapenem antibiotic, has a favorable safety profile comparable to other carbapenems and demonstrates a limited propensity to induce seizures.
Paper Details　
Original Abstract of the Article :
Carbapenems remain a mainstay for the empirical treatment of serious nosocomial infection. Although the tolerance and safety profile of the carbapenems as a class is favorable, the primary safety concern is the potential for treatment-emergent seizures. In preclinical testing, doripenem, a new carba...See full text at original site
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引用元：
https://doi.org/10.1086/599813

データ提供：米国国立医学図書館（NLM）

Doripenem: A Safe and Effective Carbapenem Antibiotic

In the field of [Infectious Diseases], carbapenem antibiotics are a cornerstone of treatment for serious nosocomial infections. This study investigates the safety and tolerability of doripenem, a new carbapenem antibiotic, in a series of clinical trials involving patients with various nosocomial infections. The authors demonstrate that doripenem exhibits a favorable safety profile, comparable to other carbapenem antibiotics, with a low incidence of treatment-emergent seizures, even when administered via a prolonged infusion.

A New Oasis in the Desert of Antibiotic Resistance: Exploring the Safety and Efficacy of Doripenem

This study introduces doripenem, a new carbapenem antibiotic, as a potential solution to the growing challenge of antibiotic resistance. The authors demonstrate the safety and tolerability of doripenem in a large cohort of patients, highlighting its potential as a valuable tool for managing serious nosocomial infections. The study's findings are particularly encouraging considering the increasing prevalence of antibiotic resistance, offering hope for a new and effective treatment option.

Navigating the Challenges of Antibiotic Resistance: A Call for Continued Research and Development

This study underscores the importance of continued research and development of new antibiotics to combat the growing threat of antimicrobial resistance. The authors' findings suggest that doripenem may be a safe and effective option for treating serious infections, highlighting the need for further exploration of this promising new antibiotic.

Dr.Camel's Conclusion

This study provides reassuring evidence for the safety and efficacy of doripenem, offering a new and promising weapon in the fight against antibiotic resistance. It's like discovering a new oasis in a vast and arid desert, providing a source of hope and relief for patients battling serious infections. The study encourages continued research and development of new antibiotics to address the growing challenge of antimicrobial resistance.

Date :
  1. Date Completed 2009-09-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19619019

DOI: Digital Object Identifier

10.1086/599813

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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