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Dextran-etodolac conjugates: synthesis, in vitro and in vivo evaluation.

Author: ChaturvediSubhash Chandra, TrivediPiyush, VyasSavita

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Etodolac is a pain reliever and anti-inflammatory drug. To improve its water solubility and reduce stomach upset, it was linked to dextran, a biodegradable polymer. The new drug (etodolac-dextran) released etodolac more quickly at pH 9 than in other environments, following a predictable pattern. In animal studies, etodolac-dextran had similar pain relief and anti-inflammatory effects as etodolac, but caused significantly less stomach ulcers.
Paper Details　
Original Abstract of the Article :
Etodolac (E), is a non-narcotic analgesic and antiinflammatory drug. A biodegradable polymer dextran has been utilized as a carrier for synthesis of etodolac-dextran conjugates (ED) to improve its aqueous solubility and reduce gastrointestinal side effects. An activated moiety, i.e. N-acylimidazole ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19719056

データ提供：米国国立医学図書館（NLM）

Dextran-Etodolac Conjugates: Synthesis, In Vitro and In Vivo Evaluation

This research explores the development of a novel drug delivery system for etodolac, a non-narcotic analgesic and antiinflammatory drug. The researchers synthesized dextran-etodolac conjugates (ED) by linking etodolac to dextran, a biodegradable polymer. The primary objective of this study was to improve the aqueous solubility, reduce gastrointestinal side effects, and enhance the efficacy of etodolac.

Dextran-Etodolac Conjugates Show Promise

The study found that dextran-etodolac conjugates (ED) exhibited improved aqueous solubility, reduced ulcerogenicity, and maintained comparable analgesic and antiinflammatory activities compared to etodolac. These findings suggest that ED could be a more effective and safer alternative to etodolac for managing pain and inflammation.

Potential for Improved Drug Delivery and Patient Outcomes

The study's findings could lead to the development of new drug delivery systems for etodolac and other drugs, potentially improving patient outcomes and reducing the incidence of adverse effects. This research offers promising insights into the potential of using biodegradable polymers to enhance the therapeutic profile of drugs.

Dr.Camel's Conclusion

Imagine a camel traversing a desert, carrying a precious load of water. Just like this camel needs a sturdy and reliable container to protect the water, drugs need efficient delivery systems to reach their target safely and effectively. This research explores a novel approach to drug delivery, using a biodegradable polymer to enhance the efficacy and safety of etodolac, offering a better journey towards healing.

Date :
  1. Date Completed 2009-09-28
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

19719056

DOI: Digital Object Identifier

19719056

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Languages

English

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