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Toxicity and biodistribution of an iodine-131-radiolabelled tumour necrosis-targeting antibody in non-tumour-bearing domestic felines.
Author: ParseghianM H, Van WalleghenD M
Original Abstract of the Article :
The potential of human immunotherapeutics now revolutionizing modern cancer therapy has yet to make an impact in veterinary medicine, mainly due to the evolutionary differences between human and non-human cell surface antigens which bar the efficacy for many antibodies targeting human antigens. Here...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.1476-5810.2006.00086.x
データ提供:米国国立医学図書館(NLM)
Radiolabelled Antibodies: A New Weapon in the Desert of Cancer Treatment
Cancer is a formidable foe, like a relentless sandstorm that can wreak havoc on the body. This study explores the potential of using radiolabelled antibodies to target and destroy tumors, a promising approach for combating this devastating disease. The researchers investigated the safety and effectiveness of a specific iodine-131-radiolabelled antibody, Cotara, in non-tumor-bearing felines, seeking to evaluate its potential as a cancer treatment.
Navigating the Desert of Toxicity
The study found that Cotara exhibited moderate toxicity in the feline subjects, resulting in transient signs of anorexia and vomiting. This finding is like encountering a patch of prickly cactus in the desert, a reminder that even promising treatments can come with challenges. However, the researchers also found that Cotara was effective in delivering iodine-131 directly to solid tumors, suggesting that it could be a valuable tool for treating cancer. They also observed that potassium iodide, used to protect the thyroid gland from radiation damage, was safe and effective.
Hope in the Desert of Cancer
This study offers a glimmer of hope for those battling cancer, suggesting that radiolabelled antibodies could be a valuable weapon in the fight against this disease. It underscores the importance of carefully evaluating the potential risks and benefits of new treatments, ensuring that they are safe and effective. The researchers' findings are a reminder that our journey through the desert of cancer research continues, and we must remain committed to finding innovative solutions to combat this devastating disease.
Dr.Camel's Conclusion
This study reminds us that the desert of cancer research is filled with both challenges and opportunities. While Cotara showed some toxicity in this study, the researchers are hopeful that it could eventually be a viable option for treating cancer. As we continue our journey through this difficult terrain, we must remain dedicated to finding new ways to combat this devastating disease.
Date :
- Date Completed 2009-12-15
- Date Revised 2009-09-16
Further Info :
Related Literature
English
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