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A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group.

Author: AlfordC, ArvinA, BurchettS, ConnorJ, CoreyL, PlotkinS, PowellD, ProberC, StarrS, WhitleyR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Vidarabine and acyclovir were equally effective in the treatment of neonatal herpes simplex virus (HSV) infection.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Despite the use of vidarabine, herpes simplex virus (HSV) infection in neonates continues to be a disease of high morbidity and mortality. We undertook a controlled trial comparing vidarabine with acyclovir for the treatment of neonatal HSV infection. METHODS: Babies less than one month...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199102143240703

データ提供：米国国立医学図書館（NLM）

Neonatal Herpes Simplex Virus Infection: Fighting a Fierce Foe

Herpes simplex virus (HSV) infection can be a devastating condition, especially in newborns. This research compares the effectiveness of two antiviral medications, vidarabine and acyclovir, in treating neonatal HSV infection. It's like having two different swords to fight the same ferocious dragon.

A Comparative Study of Antiviral Treatments

The study enrolled 202 newborns with HSV infection and randomly assigned them to receive either vidarabine or acyclovir. The results showed no significant difference in mortality or morbidity between the two groups. It's like finding that both swords are equally sharp and effective in battling the dragon.

Protecting Newborns: A Quest for Effective Treatment

This research provides valuable insights into the treatment of neonatal HSV infection. It's like a guidebook to help navigate the treacherous terrain of this dangerous disease. The study's findings suggest that both vidarabine and acyclovir are effective treatments, offering hope for newborns battling this challenging condition.

Dr.Camel's Conclusion

This research highlights the importance of finding effective treatments for neonatal HSV infection, a serious threat to newborns. It's like a quest for a cure, a journey through a challenging desert landscape. The study's findings offer a glimmer of hope, demonstrating that both vidarabine and acyclovir can effectively combat this disease, paving the way for a healthier future for newborns.

Date :
  1. Date Completed 1991-02-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1988829

DOI: Digital Object Identifier

10.1056/NEJM199102143240703

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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