Effective treatment of digestive diseases: A Synthesis of Findings from 52 Studies

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Original Abstract of the Article

Major Research Findings

Herpes simplex virus (HSV) infection is a common condition that can affect various parts of the body, leading to diverse symptoms. 14 explores the characteristics of genital herpes, highlighting the distinct features between primary and recurrent infections, as well as the differences in symptoms caused by HSV type 1 and type 2. 4 focuses on oral herpes (herpes labialis), examining the effectiveness of oral acyclovir in treating recurring outbreaks. This study found that oral acyclovir significantly reduced the frequency of positive virus cultures, indicating its effectiveness in controlling the infection. 36 explores the potential of laser phototherapy as an alternative treatment for herpes labialis. The research suggests that laser phototherapy may be effective in reducing the size and inflammation of herpes lesions, potentially offering a new avenue for managing this condition. 30 delves into the connection between HSV infection and HIV infection, highlighting the increased risk of acquiring HIV in individuals with HSV seropositivity. The study suggests that HSV reactivation can disrupt the epithelial barrier and recruit activated CD4 cells, making individuals more susceptible to HIV infection. 25 investigates the treatment of herpes simplex virus epithelial keratitis, a common form of ocular HSV infection. The research compares the efficacy of various treatments for dendritic or geographic HSV epithelial keratitis, aiming to inform evidence-based ophthalmological practice. These studies demonstrate that different treatment approaches can impact the speed of corneal healing.

Treatment Summary

14 highlights the effectiveness of intravenous acyclovir in treating severe first episodes of genital herpes. The study found that intravenous acyclovir significantly shortened the duration of viral shedding, healing time, vesicle duration, new lesion formation, and overall symptom duration. However, it did not prevent future recurrences. 4 explores the use of oral acyclovir in treating recurrent herpes labialis. The study found that oral acyclovir significantly reduced the frequency of positive virus cultures and hastened lesion resolution when initiated early in the prodrome or erythema lesion stage. 36 suggests that laser phototherapy may be a viable alternative treatment option for herpes labialis, as it showed promise in reducing lesion size and inflammation. 27 investigates the effectiveness of topical penciclovir cream for treating herpes simplex facialis/labialis, finding it to be as effective and safe as 3% acyclovir cream. 44 explores various treatment approaches for HSV epithelial keratitis, comparing the effectiveness of antiviral agents, interferon, and corneal debridement. The study concludes that trifluridine and acyclovir are more effective than idoxuridine or vidarabine and that brivudine and foscarnet are similar in effectiveness to trifluridine or acyclovir. 3 compares vidarabine and acyclovir in treating neonatal HSV infection, finding no significant differences in outcomes between the two antiviral agents.

Benefits and Risks

Benefit Summary

Treating HSV infections offers numerous benefits, including a reduction in the duration of viral shedding, faster healing times, reduced symptom duration, and potentially even a decrease in the frequency of recurrences. A variety of medications and therapies are available, such as oral acyclovir, valacyclovir, penciclovir, and laser phototherapy, which have shown promise in managing different types of HSV infections. These treatments can significantly improve the patient's experience and quality of life.

Risk Summary

While treatments for HSV infections generally have a good safety profile, there are potential risks that patients should be aware of. Some medications, such as oral acyclovir, valacyclovir, and penciclovir, can cause mild side effects like nausea, vomiting, diarrhea, rash, headache, or dizziness. Laser phototherapy can occasionally cause skin burns or pigmentation changes. It is crucial to consult with a healthcare professional to discuss individual risks and benefits and to ensure proper treatment and monitoring.

Comparison Across Studies

Research Similarities

Across multiple studies, acyclovir and valacyclovir have consistently emerged as effective antiviral treatments for various HSV infections. These medications demonstrate effectiveness in reducing viral shedding, shortening healing times, and alleviating symptoms. Additionally, some studies indicate that laser phototherapy may be a promising alternative treatment for herpes labialis.

Research Differences

The treatment approach for HSV infection varies depending on the specific type of herpes and the location of infection. 14 suggests that intravenous acyclovir is particularly effective for severe first episodes of genital herpes. For recurrent herpes labialis, oral acyclovir and penciclovir cream have been found to be effective treatments ( 4 , 27 ). Laser phototherapy shows promise for herpes labialis but requires further research ( 36 ). The treatment of HSV epithelial keratitis involves a range of antiviral agents, interferon, and corneal debridement, with varying degrees of effectiveness as demonstrated in 44 . The treatment of neonatal HSV infection has been investigated with vidarabine and acyclovir, with no significant differences observed between the two ( 3 ).

Consistency and Contradictions in Results

The research consistently points to the effectiveness of acyclovir and valacyclovir in managing HSV infections, but it remains unclear whether these medications can completely prevent future recurrences. While laser phototherapy shows promise as a potential alternative treatment for herpes labialis, more research is needed to solidify its efficacy and safety.

Practical Implications and Considerations

HSV infections are often recurrent, and complete eradication is not always achievable. Therefore, it is essential to seek prompt medical attention when symptoms appear. Individuals with HSV infections should take preventative measures to minimize the risk of spreading the virus, such as avoiding sharing personal items like towels and utensils, practicing good hand hygiene, and using barrier methods like condoms during sexual activity.

Limitations of Current Research

Further research is needed to develop treatments that can completely prevent recurrences of HSV infections. Additional studies are also required to fully evaluate the efficacy and safety of newer treatments like laser phototherapy.

Future Research Directions

Future research should focus on developing new treatments that can effectively prevent HSV recurrences. More in-depth studies are needed to assess the long-term efficacy and safety of laser phototherapy and other emerging treatments. Research into preventative strategies that can reduce the initial risk of HSV infection would also be beneficial.

Conclusion

HSV infections are a common condition that can cause various symptoms, but effective treatments are available to manage the condition and improve quality of life. While acyclovir and valacyclovir have proven to be effective in reducing symptoms and viral shedding, research is ongoing to develop more potent and preventative treatments. It is essential to consult with a healthcare professional for proper diagnosis, treatment, and advice on managing HSV infection.

Treatment List

Acyclovir, valacyclovir, penciclovir, laser phototherapy, trifluridine, interferon, topical heparin, bromovinyldeoxyuridine, ribavirin, docosanol

Keywords
Benefit Keywords
Reduced herpes simplex pain
1
Herpes simplex treatment
2
Herpes simplex labialis treatment
4
Reduced herpes recurrence
5
Ribavirin efficacy
6
Reduced recurrence frequency
7
Improved genital herpes treatment
8
Reduced healing time
Reduced symptom duration
9
Herpes treatment
10
Trifluridine effective
11
Accelerated healing
Reduced duration of viral shedding
Reduced symptom duration
12
Reduced duration
Reduced severity
13
Improved healing time
Reduced symptom duration
Reduced viral shedding
14
Improved healing time
Reduced symptom duration
Reduced viral shedding
15
Herpes simplex keratitis treatment
17
Herpes simplex virus treatment
18
Improved understanding of genital herpes
19
Possible benefit for HSV iridocyclitis
20
Convenient dosing
Effective treatment
21
Reduced HSV recurrence
Reduced orofacial HSV
22
Improved herpes zoster and genital herpes treatment
23
Effective HSV treatment
24
Effective treatment for HSV epithelial keratitis
25
Treats HSL
26
Improved clinical course
27
Aborts HSV lesions
Prevents HSV lesions
28
Reduced HSK recurrence
29
HIV prevention
Reduced HIV transmission
30
HSV eye disease prevention
31
Improved herpes simplex treatment
32
Herpes treatment
33
Improved herpes simplex labialis treatment
34
Neonatal HSV infection treatment
35
Reduced herpes severity
Reduced lesion size
36
RGH treatment
37
HIV treatment
38
Improved corneal healing
39
HSK pathogenesis reduction
HSK symptom relief
40
Improved lesion healing
41
HSK treatment
42
HSV keratitis treatment
44
Reduced symptom duration
46
Oral herpes virus treatment
47
HSL treatment
48
Herpes labialis treatment
49
Improved HSL treatment
50
HSV-1 treatment
51
Management of genital herpes infection
52
Risk Keywords
Increased herpes recurrence
1
Debridement ineffective
11
Placebo effect
13
Side effects
17
Mild adverse events
21
No rebound in HSV
22
Headache
Nausea
31
Herpes simplex
32
Herpes simplex labialis
34
Recurrence
40
Adverse events
41
Adverse events
46
Literature analysis of 52 papers
Positive Content
48
Neutral Content
3
Negative Content
1
Article Type
42
7
8
8
52
1.

Treatment of recurrent herpes simplex labialis with levamisole.

Author: SpruanceS L, KruegerG G, MacCalmanJ, OverallJ C, KlauberM R

Reduced herpes simplex pain
Increased herpes recurrence

A study of 42 patients with frequent cold sores found that levamisole, an immune-boosting drug, did not prevent cold sores and actually increased the frequency of outbreaks as the dose increased. However, the duration and pain of the sores decreased with higher doses. The study concluded that levamisole is not an effective treatment for recurrent cold sores. The paradoxical response to this immune-modulating drug suggests that altered immune responses may play a role in the development of cold sores.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Treatment of recurrent herpes labialis using a herpes simplex Type-I subunit vaccine. A prospective randomized double-blind multicenter study].

Author: AltmeyerP, WehrenbergO, HolzmannH, PaulE, KimmigW K, WassilewS W, PetresJ, KorgerG

Herpes simplex treatment

A study of 82 patients with recurrent oral herpes compared a herpes simplex type I subunit vaccine to a placebo. Over an 8-month period, there was no statistically significant difference in the frequency of outbreaks between the vaccine and placebo groups. Both groups showed a reduction in outbreaks, but the placebo group had a slightly greater decrease in recurrence frequency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

3.

A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group.

Author: WhitleyR, ArvinA, ProberC, BurchettS, CoreyL, PowellD, PlotkinS, StarrS, AlfordC, ConnorJ

Vidarabine and acyclovir were equally effective in the treatment of neonatal herpes simplex virus (HSV) infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Treatment of recurrent herpes simplex labialis with oral acyclovir.

Author: SpruanceS L, StewartJ C, RoweN H, McKeoughM B, WenerstromG, FreemanD J

Herpes simplex labialis treatment

Acyclovir (400 mg five times daily for 5 days) was more effective than placebo in reducing the frequency of positive herpes simplex labialis cultures. Acyclovir also hastened lesion resolution when started early in the prodrome or erythema stage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

A prospective study of the effects of acyclovir treatment on the HSV-2 lymphoproliferative response of persons with frequently recurring HSV-2 genital infections.

Author: FrenkelL, PinedaE, GarrattyE, FallH, DillonM, BrysonY

Reduced herpes recurrence

This study examined the effect of acyclovir on lymphocyte response to herpes simplex virus type 2 (HSV-2) in patients with frequent genital herpes outbreaks. Patients with frequent outbreaks had lower initial HSV-2-specific lymphocyte proliferation (HSV-2-LP) compared to those with infrequent outbreaks. Both daily suppressive acyclovir (S-ACV) and acyclovir given for five days during outbreaks (PLC/ACV) increased HSV-2-LP, but this increase did not correlate with a change in the frequency of outbreaks. S-ACV effectively reduced outbreaks, while PLC/ACV did not. The findings suggest that low HSV-2-LP may be associated with frequent outbreaks, and while acyclovir treatment can increase HSV-2-LP, this response doesn't predict the effectiveness of treatment in preventing outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Clinical and immunological evaluation of oral ribavirin administration in recurrent herpes simplex infections.

Author: PalmieriG, AmbrosiG, FerraroG, AgratiA M, PalazziniE

Ribavirin efficacy

This study compared the effectiveness of ribavirin to placebo in treating 38 patients with recurrent herpes simplex virus infections. Ribavirin was more effective in treating outbreaks of herpes simplex virus type 1, especially when treatment began early. The study found no significant side effects or changes in immune function. The study concludes that ribavirin is an effective and safe treatment for recurrent herpes simplex virus type 1 infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Acyclovir in first attacks of genital herpes and prevention of recurrences.

Author: MindelA, WellerI V, FahertyA, SutherlandS, FiddianA P, AdlerM W

Reduced recurrence frequency

A study of 60 patients with first-time genital herpes found that oral acyclovir for 42 days was more effective in delaying the first recurrence compared to a 5-day course of acyclovir followed by placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Topical heparin for recurrent genital herpes simplex virus infections. A proposed model for subsequent therapeutic trials.

Author: GrossmanJ H, Thonnard-NeumannE

Improved genital herpes treatment

A study compared the effectiveness of topical heparin to placebo for recurrent genital herpes simplex virus (HSV) infections. The study was designed to serve as a model for others interested in studying outpatient treatment for genital HSV.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Treatment of recurrent genital herpes simplex infections with oral acyclovir.

Author: Ruhnek-ForsbeckM, SandströmE, AnderssonB, ErikssonG, HersleK, LövhagenG B, MobackenH, HillströmL, SvenssonL

Reduced healing time
Reduced symptom duration

A study of 113 patients with recurrent genital herpes found that acyclovir significantly reduced the duration of herpes outbreaks compared to placebo. Acyclovir shortened the time to crusting and healing, as well as the duration of symptoms and new lesions. Acyclovir was well-tolerated with no significant side effects. The study suggests that early treatment with acyclovir may stop herpes outbreaks before they progress to more severe stages.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection.

Author: Meyrick ThomasR H, DoddH J, YeoJ M, KirbyJ D

Herpes treatment

A study of 11 patients with frequent non-genital herpes simplex virus (HSV) outbreaks found that oral acyclovir significantly reduced the number of outbreaks compared to placebo. Only 2 patients experienced an outbreak while taking acyclovir for up to 12 weeks, compared to 9 on placebo. While acyclovir effectively prevented lesions, some patients still experienced prodromal symptoms or erythema. The time to the next outbreak after stopping treatment was similar for both groups. The study concludes that acyclovir is effective and well-tolerated in suppressing recurrent non-genital HSV infections in people with healthy immune systems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Role of débridement and trifluridine (trifluorothymidine) in herpes simplex dendritic keratitis.

Author: ParlatoC J, CohenE J, SakauyeC M, DreizenN G, GalentineP G, LaibsonP R

Trifluridine effective
Debridement ineffective

A study of 34 patients with herpes simplex dendritic keratitis compared three treatments: debridement alone, trifluridine alone, and debridement plus trifluridine. Debridement alone had a higher failure rate compared to the other two treatments. Trifluridine alone and debridement plus trifluridine showed similar healing times. These findings suggest that debridement alone is not an effective treatment for this condition, and that combining debridement with trifluridine does not provide additional benefit compared to trifluridine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection.

Author: MertzG J, CritchlowC W, BenedettiJ, ReichmanR C, DolinR, ConnorJ, RedfieldD C, SavoiaM C, RichmanD D, TyrrellD L

Accelerated healing
Reduced duration of viral shedding
Reduced symptom duration

A study of 150 patients with first-episode genital herpes found that oral acyclovir significantly shortened the duration of viral shedding, symptoms, and healing for patients with primary genital herpes. It did not affect subsequent recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

Topical ether and herpes simplex labialis.

Author: GuinanM E, MacCalmanJ, KernE R, OverallJ C, SpruanceS L

Reduced duration
Reduced severity
Placebo effect

A study of 51 patients with recurrent cold sores found no significant difference in effectiveness between topical ether and placebo. While both groups reported similar improvements in symptom severity and duration, objective measures like lesion progression, healing time, pain, and viral shedding did not show a difference. This suggests that the perceived improvement in both groups may be due to a placebo effect. The study highlights the importance of using objective measurements and placebo-controlled studies when evaluating treatments for recurrent herpes infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Genital herpes - the disease and its treatment including intravenous acyclovir.

Author: MindelA, SutherlandS

Improved healing time
Reduced symptom duration
Reduced viral shedding

This paper reviews the natural history of genital herpes, previous treatment options, and a double-blind placebo-controlled trial of intravenous acyclovir for severe first-episode genital herpes. Intravenous acyclovir was effective in reducing symptoms and duration of lesions, but did not prevent subsequent recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Current status and prospects for oral acyclovir treatment of first episode and recurrent genital herpes simplex virus.

Author: BrysonY J

Improved healing time
Reduced symptom duration
Reduced viral shedding

Oral acyclovir was found to be effective in treating both primary and recurrent genital herpes, significantly reducing viral shedding, lesion formation, and symptom duration compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis.

Author: DiGiovannaJ J, BlankH

A double-blind, placebo-controlled trial of lysine hydrochloride for recurrent herpes simplex infection found no significant benefit in reducing episode frequency, duration, or severity, either as a treatment or prophylaxis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Efficacy of four antiviral agents in the treatment of uncomplicated herpetic keratitis.

Author: PandaA, DasG K, KhokharS, RaoV

Herpes simplex keratitis treatment
Side effects

BVDU has a more pronounced therapeutic effect than idoxuridine, trifluorothymidine and acyclovir in uncomplicated epithelial herpetic disease of recent onset that has not previously been treated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Increased effects of topically applied interferon on herpes simplex virus-induced lesions by caffeine.

Author: VonkaV, PetrovskáP, BoreckýL, RothZ

Herpes simplex virus treatment

A clinical trial showed that topical caffeine and interferon combination therapy was more effective than either drug alone in shortening healing and spreading time of recurrent herpetic lesions. While placebo had negligible effect, caffeine alone shortened healing time by at least 4 days in 75% of patients, interferon alone in 88%, and combination therapy in all patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Human leukocyte interferon-alpha in cream for the treatment of genital herpes in Asian males. A placebo-controlled, double-blind study.

Author: SyedT A, CheemaK M, KahlonB M, KahlonR C, KhayyamiM, KahlonA M, KahlonM M

Improved understanding of genital herpes

Genital herpes is a common sexually transmitted infection that causes genital sores. It is a recurring condition and can contribute to cervical abnormalities in women and cause neonatal herpes in newborns.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group.

Author:

Possible benefit for HSV iridocyclitis

Oral acyclovir, in conjunction with topical corticosteroids and trifluridine, may be beneficial in the treatment of HSV iridocyclitis. Although the study was underpowered, the trend in the results suggests a potential benefit.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes: a randomised, double blind clinical trial. International Valaciclovir HSV Study Group.

Author: BodsworthN J, CrooksR J, BorelliS, VejlsgaardG, PaavonenJ, WormA M, UexkullN, EsmannJ, StrandA, IngamellsA J, GibbA

Convenient dosing
Effective treatment
Mild adverse events

Valaciclovir 500 mg twice daily is equivalent in efficacy to aciclovir 200 mg five times daily as episodic treatment of recurrent genital HSV infection. Valaciclovir maintains the established efficacy and safety of aciclovir but offers a much more convenient twice daily dosing regimen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group.

Author:

Reduced HSV recurrence
Reduced orofacial HSV
No rebound in HSV

This study found that 12 months of treatment with acyclovir reduces the rate of recurrent ocular HSV disease and orofacial HSV disease in patients with a history of ocular HSV disease. The study suggests that long-term antiviral prophylaxis is most important for patients with a history of HSV stromal keratitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

23.

Advances in the treatment of herpesvirus infection: the role of famciclovir.

Author: TyringS K

Improved herpes zoster and genital herpes treatment

Shingles, caused by reactivation of the chickenpox virus, can cause significant pain and lead to a long-term complication called postherpetic neuralgia, which affects 3.4 people per 1,000 each year. Genital herpes, caused by a different type of herpes virus, can cause recurrent outbreaks multiple times per year for some people. Antiviral medications like famciclovir, valacyclovir, and acyclovir can reduce the severity and duration of these conditions, and may even prevent future outbreaks of genital herpes. This review summarizes the causes of shingles and genital herpes and discusses 12 studies demonstrating the effectiveness of famciclovir in treating both conditions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Efficacy and safety of famciclovir for treating mucocutaneous herpes simplex infection in HIV-infected individuals. Collaborative Famciclovir HIV Study Group.

Author: RomanowskiB, AokiF Y, MartelA Y, LavenderE A, ParsonsJ E, SaltzmanR L

Effective HSV treatment

Famciclovir given twice a day is as effective and well tolerated as high-dose acyclovir for mucocutaneous HSV infections in HIV-infected individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

The treatment of herpes simplex virus epithelial keratitis.

Author: WilhelmusK R

Effective treatment for HSV epithelial keratitis

Herpes simplex virus (HSV) infection is a common cause of eye inflammation (keratitis). This study compared different treatments for HSV keratitis, which can cause sores on the cornea, and found that some treatments were more effective than others. The study also looked at how certain characteristics of the eye infection affected how quickly the sores healed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial.

Author: SacksS L, ThistedR A, JonesT M, BarbarashR A, MikolichD J, RuoffG E, JorizzoJ L, GunnillL B, KatzD H, KhalilM H, MorrowP R, YakatanG J, PopeL E, BergJ E,

Treats HSL

Docosanol 10% cream applied 5 times daily is safe and effective in the treatment of recurrent herpes simplex labialis, with a median healing time of 4.1 days, 18 hours shorter than placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Topical application of penciclovir cream for the treatment of herpes simplex facialis/labialis: a randomized, double-blind, multicentre, aciclovir-controlled trial.

Author: LinL, ChenX S, CuiP G, WangJ B, GuoZ P, LuN Z, BiZ G, JiaH, YangX Y,

Improved clinical course

Topical 1% penciclovir cream is as convenient and as effective as 3% aciclovir cream for the treatment of HSFL.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir.

Author: StrandA, PatelR, WulfH C, CoatesK M,

Aborts HSV lesions
Prevents HSV lesions

Episodic valaciclovir significantly increased the chance of preventing or aborting painful genital herpes simplex virus (HSV) lesions compared to placebo. This study explores the clinical outcome of aborted lesions and its association with early treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis.

Author: WuXinyi, ChenXuan

Reduced HSK recurrence

Long-term and low-dose oral acyclovir for prophylaxis of recurrent epithelial herpes simplex infection and therapeutic doses of oral acyclovir reduce both the rate and duration of recurrences of infectious herpes simplex keratitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

The interaction between herpes simplex virus and human immunodeficiency virus.

Author: CelumConnie L

HIV prevention
Reduced HIV transmission

This review highlights the increased risk of HIV acquisition and transmission associated with herpes simplex virus (HSV)-2 infection, suggesting that antiherpetic therapy could potentially reduce HIV transmission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

31.

Efficacy of valacyclovir vs acyclovir for the prevention of recurrent herpes simplex virus eye disease: a pilot study.

Author: MiserocchiElisabetta, ModoratiGiulio, GalliLaura, RamaPaolo

HSV eye disease prevention
Headache
Nausea

A one-year treatment with oral valacyclovir (500 mg daily) was as effective and well-tolerated as acyclovir (400 mg twice daily) in reducing the recurrence rate of ocular herpes simplex virus (HSV) disease. The recurrence rate was 23.1% in both groups, with no significant differences in the frequency or severity of side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

[Local phototherapy and pulse current in complex treatment of relapsing herpes simplex].

Author: TsiskarishviliN V, TsiskarishviliN I, TsiskarishviliTs I

Improved herpes simplex treatment
Herpes simplex

This study compared the effectiveness of two treatments for recurring herpes simplex: light therapy (phototherapy) alone and light therapy combined with electrical stimulation (pulse current). The study found that both treatments were effective, suggesting that energy-based treatments could be an alternative to medication.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

33.

Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir.

Author: NunesOdilon da Silva, PereiraRicardo de Souza

Herpes treatment

A formulation containing melatonin and SB-73 was found to be more effective than Acyclovir in treating herpes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial.

Author: HullC, McKeoughM, SebastianK, KrieselJ, SpruanceS

Improved herpes simplex labialis treatment
Herpes simplex labialis

Treating cold sores (herpes simplex labialis, HSL) has limited benefits. This is because the immune system quickly resolves the infection, leaving a short window for treatment. The immune response is also responsible for symptoms like swelling and pain. Similar to other infections, the immune system plays a dual role, both protecting and causing symptoms. Adding corticosteroids to antiviral medication may help improve symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Antiviral agents for treatment of herpes simplex virus infection in neonates.

Author: JonesCheryl A, WalkerKaren S, BadawiNadia

Neonatal HSV infection treatment

Herpes simplex virus (HSV) infection is a rare but serious condition in newborns. Before antiviral medications were available, the death rate was high for all but localized infections, with 85% of babies with widespread HSV dying within a year, and 50% of babies with brain infection also dying. Survivors of widespread HSV infection often had long-term neurological problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study.

Author: de CarvalhoRenata Rodrigues, de Paula EduardoFernanda, RamalhoKaren Müller, AntunesJosé Leopoldo Ferreira, BezinelliLetícia Mello, de MagalhãesMarina Helena Cury Gallottini, PegorettiTatiana, de FreitasPatrícia Moreira, de Paula EduardoCarlos

Reduced herpes severity
Reduced lesion size

This study evaluated the effectiveness of laser phototherapy in preventing and reducing the severity of labial manifestations of herpes labialis virus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients.

Author: LeonePeter, AbudaluMohamed, MithaEssack, GaniMashra, ZhouWenchun, HamedKamal

RGH treatment

While there is no evidence that race affects how genital herpes develops or responds to treatment, clinical trials on recurrent genital herpes (RGH) often include a small number of Black participants, despite high rates of herpes infection in this population.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial.

Author: TanDarrell H S, RaboudJanet M, KaulRupert, GrinsztejnBeatriz, CahnPedro, WalmsleySharon L

HIV treatment

While HIV treatment has significantly improved, the potential to delay starting treatment is appealing due to costs, side effects, and the risk of resistance. This study suggests that treating herpes simplex virus type 2 (HSV-2) infection could be a way to achieve this goal. HSV-2 is linked to increased HIV viral levels, which drives the progression of HIV disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Author: WilhelmusKirk R

Improved corneal healing

Trifluridine and acyclovir were more effective than idoxuridine or vidarabine in treating acute HSV epithelial keratitis. In a review of 106 comparative trials involving 5872 eyes, trifluridine and acyclovir were found to be superior in promoting corneal healing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

[Clinical assessment of oral ganciclovir capsules on the treatment of herpes simplex keratitis].

Author: WangXin, XuJian-jiang, LEQi-hua, WangYan, WangWen-tao

HSK pathogenesis reduction
HSK symptom relief
Recurrence

Oral ganciclovir was effective in treating herpes simplex keratitis (HSK). In a randomized controlled trial involving 60 patients, oral ganciclovir was associated with significant improvements in symptoms and signs of HSK, including stromal keratitis and corneal endotheliitis.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

41.

ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study.

Author: TyringStephen, WaldAnna, ZadeikisNeddie, DhaddaShobha, TakenouchiKazumasa, RorigRamona

Improved lesion healing
Adverse events

ASP2151 was effective and safe in treating episodes of recurrent genital herpes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis.

Author: WangXin, WangLinnong, WuNianlang, MaXinjun, XuJianjiang

HSK treatment

Herpes simplex keratitis (HSK), a serious eye infection caused by the herpes simplex virus, is a leading cause of blindness worldwide. This study investigates the effectiveness of oral ganciclovir (GCV) in preventing HSK from recurring.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Genital herpes: oral antiviral treatments.

Author: HollierLisa M, EppesCatherine

A systematic review of 8 studies found that aciclovir, famciclovir, and valaciclovir are effective treatments for genital herpes. The choice of antiviral depends on individual factors and the severity of infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Author: WilhelmusKirk R

HSV keratitis treatment

A systematic review of 137 studies found that trifluridine and acyclovir are more effective than idoxuridine or vidarabine for treating HSV epithelial keratitis. Brivudine and foscarnet were not substantially different from trifluridine or acyclovir. The addition of interferon or debridement to antiviral treatment needs further research to determine its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Hospital risk management of cutaneous herpes simplex virus infection.

Author: ZhuF, ZhangJ, FengJ, YangH

This research examined the efficacy and safety of different formulations of valaciclovir for treating cutaneous herpes simplex infections (CHSIs). Valaciclovir is a commonly used antiviral medication for CHSIs, and the study explored potential differences in effectiveness based on dosage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

46.

Interventions for men and women with their first episode of genital herpes.

Author: HeslopRachel, RobertsHelen, FlowerDeralie, JordanVanessa

Reduced symptom duration
Adverse events

Oral acyclovir was found to reduce the duration of symptoms for first-episode genital herpes, but the evidence was of low quality due to limitations in the included studies. There was no evidence that topical antivirals reduced symptom duration for patients with first-episode genital herpes. Further research is needed to provide more conclusive evidence on the effectiveness of various treatments for first-episode genital herpes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data.

Author: CrimiSalvatore, FiorilloLuca, BianchiAlberto, D'AmicoCesare, AmorosoGiulia, GorassiniFrancesca, MastroieniRoberta, MarinoStefania, ScoglioCristina, CatalanoFrancesco, CampagnaPaola, BocchieriSalvatore, De StefanoRosa, FiorilloMaria Teresa, CicciùMarco

Oral herpes virus treatment

Herpes simplex virus (HSV) infection is common and can cause painful mouth sores. This review examines the symptoms and treatment options for oral herpes, including medications, creams, laser treatments, and other approaches. Herpes can affect oral health and have a negative impact on mental well-being.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Efficacy of a topical herbal and mineral formulation (Dynamiclear) for the treatment of herpes simplex labialis in the community setting: study protocol for a randomised, double-blind placebo-controlled trial.

Author: ArmourMike, SempriniAlex, EeCarolyn, MacCullaghLois, ShorttNick

HSL treatment

This study aims to determine if Dynamiclear, an over-the-counter treatment, can effectively reduce the duration and severity of cold sores, also known as herpes simplex labialis (HSL), compared to standard treatment with aciclovir.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant).

Author: La SelvaAndreia, NegreirosRenata Matalon, BezerraDaniela Teixeira, RosaEllen Perin, PavesiVanessa Christina Santos, NavarroRicardo Scarparo, Bello-SilvaMarina Stella, RamalhoKaren Müller, AranhaAna Cecília Corrêa, Braz-SilvaPaulo Henrique, FernandesKristianne Porta Santos, BussadoriSandra Kalil, HorlianaAnna Carolina Ratto Tempestini

Herpes labialis treatment

This study will evaluate the effectiveness of photodynamic therapy (PDT) for treating cold sores, which are caused by the herpes simplex virus. While the current medication, acyclovir, can shorten the duration of cold sores, it can lead to resistance and doesn't prevent recurrence. PDT offers potential advantages by reducing healing time and avoiding resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

Clinical Study on the Effectiveness of Three Products in the Treatment of Herpes Simplex Labialis.

Author: BoesHanna, GoulioumisVlasios, WechslerAnna, ZimmerStefan, BizhangMozhgan

Improved HSL treatment

This prospective, randomized, examiner-blind study compared the effectiveness of three different products (Herpatch Serum, Compeed Patches, and Zovirax Cream) in treating herpes simplex labialis (HSL), finding that Herpatch was effective and non-antiviral.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Photodynamic therapy and Acyclovir in the treatment of recurrent herpes labialis: A controlled randomized clinical trial.

Author: RamalhoKaren Müller, CunhaSandra Ribeiro, GonçalvesFlavia, EscudeiroGustavo Silva, Steiner-OliveiraCarolina, HorlianaAnna Carolina Rato Tempestini, EduardoCarlos de Paula

HSV-1 treatment

Herpes Simplex Virus Type 1 (HSV-1) is a common infection that can cause sores around the mouth. Outbreaks can cause pain, discomfort, and social problems due to their appearance. This study will compare two treatments, photodynamic therapy (PDT) and topical acyclovir (AC), alone and combined, to see how well they help heal outbreaks and reduce symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Diagnosis and Management of Genital Herpes: Key Questions and Review of the Evidence for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.

Author: JohnstonChristine

Management of genital herpes infection

This systematic review informed the 2021 Centers for Disease Control and Prevention (CDC) STI treatment guidelines for genital herpes infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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