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Genetic polymorphism of the human cytochrome P450 2C9 gene and its clinical significance.

Author: HuangS-Q, SuH-H, WangB, WangJ, ZhouS-F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

CYP2C9, an enzyme responsible for metabolizing numerous drugs, has genetic variants that can affect drug efficacy and toxicity. Genetic testing for CYP2C9 polymorphisms may help personalize drug therapy for individuals.
Paper Details　
Original Abstract of the Article :
Human cytochrome P450 2C9 (CYP2C9) accounts for approximately 20% of total hepatic CYP content and metabolizes approximately 15% clinically used drugs including S-warfarin, tolbutamide, phenytoin, losartan, diclofenac, and celecoxib. To date, there are at least 33 variants of CYP2C9 (*1B through to ...See full text at original site
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引用元：
https://doi.org/10.2174/138920009789895480

データ提供：米国国立医学図書館（NLM）

CYP2C9 Polymorphism: A Genetic Twist on Drug Metabolism

Our bodies are complex chemical factories, and a key part of this intricate machinery is the cytochrome P450 system, a group of enzymes responsible for breaking down drugs and other substances. One particular enzyme, CYP2C9, is crucial for metabolizing a wide range of medications, including warfarin (a blood thinner), certain antidiabetic drugs, and some nonsteroidal anti-inflammatory drugs (NSAIDs).

This research explores the genetic variations in CYP2C9 and how these variations can affect how individuals respond to medications. The researchers found that certain genetic variants, like CYP2C9*2 and CYP2C9*3, can influence the enzyme's activity, leading to variations in drug metabolism. These variations can affect how effective a drug is and even increase the risk of side effects. This study emphasizes the importance of considering individual genetic differences when prescribing medications, particularly those metabolized by CYP2C9.

Tailoring Treatment to the Individual

The findings highlight the significance of personalized medicine, where treatments are tailored to individual genetic profiles. This research provides valuable insights for clinicians in understanding how genetic variations in CYP2C9 can affect drug efficacy and safety.

Navigating the Labyrinth of Drug Metabolism

This research sheds light on the complexity of drug metabolism and the influence of genetic factors. It reminds us that the same drug can have different effects on different individuals, depending on their unique genetic makeup. This knowledge is crucial for optimizing drug therapy and ensuring patient safety.

Dr. Camel's Conclusion

Just like a camel needs to adapt to the harsh desert environment, our bodies need to adapt to different medications. This research reminds us that genetic variations can influence drug metabolism, highlighting the importance of personalized medicine to ensure the best possible outcomes for patients.

Date :
  1. Date Completed 2010-09-17
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

19925388

DOI: Digital Object Identifier

10.2174/138920009789895480

SNS
PICO Info
in preparation
Languages

English

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