A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer's disease: a post hoc analysis.

Author: AlvaGus, FarlowMartin R, MengXiangyi, OlinJason T

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To investigate the tolerability and efficacy of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer's disease receiving concomitant memantine. RESEARCH DESIGN AND METHODS: Post hoc analysis of a 25-week, randomized, prospective, open-label, parallel-group study...See full text at original site
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引用元:
https://doi.org/10.1185/03007990903434914

データ提供:米国国立医学図書館(NLM)

Rivastigmine Transdermal Patches: A Post-Hoc Analysis for Alzheimer's Disease

This study investigates the effectiveness and tolerability of rivastigmine transdermal patches in patients with mild-to-moderate Alzheimer's disease, focusing on the impact of concomitant memantine therapy. The researchers analyzed data from a 25-week, open-label trial to understand the interplay between these two medications.

Evaluating the Efficacy and Safety of Rivastigmine

This study provides valuable insights into the use of rivastigmine transdermal patches in patients with Alzheimer's disease. The research indicates that rivastigmine appears well-tolerated, even when used concurrently with memantine, and does not adversely affect cognitive or global functioning. However, the study notes a higher incidence of adverse events in patients receiving both medications.

Treatment Options for Alzheimer's Disease

The findings suggest that rivastigmine transdermal patches may be a viable treatment option for Alzheimer's disease, even when combined with memantine. However, healthcare professionals should carefully monitor patients for potential adverse events and individualize treatment plans based on patient needs and responses.

Dr.Camel's Conclusion

This research offers valuable data for clinicians managing Alzheimer's disease. It sheds light on the potential benefits and risks of rivastigmine transdermal patches, particularly when used in combination with memantine. The study encourages careful monitoring of patients and individualized treatment approaches to ensure optimal care for those living with Alzheimer's disease.

Date :
  1. Date Completed 2010-04-30
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19929593

DOI: Digital Object Identifier

10.1185/03007990903434914

Related Literature

SNS
PICO Info
in preparation
Languages

English

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