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Preparation, characterization and evaluation of a biopolymeric gold nanocomposite with antimicrobial activity.

Author: ChamundeeswariMunusamy, DeviM Pandima, JacobJustin P, KumarM Ganesh, MandalAsit B, SastryThotapalli P, SobhanaS S Liji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chitosan-capped gold nanoparticles coupled with ampicillin (C-AuNp-Amp) showed a 2-fold increase in antimicrobial activity compared to ampicillin alone, allowing for a 50% reduction in antibiotic dosage and minimized side effects.
Paper Details　
Original Abstract of the Article :
The present study describes the antimicrobial activity of C-AuNp-Amp (chitosan-capped gold nanoparticles coupled with ampicillin). C-AuNp-Amp was synthesized using the wet precipitation method and characterized using FTIR (Fourier-transform IR) spectroscopy and AFM (atomic force microscopy) techniqu...See full text at original site
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引用元：
https://doi.org/10.1042/BA20090198

データ提供：米国国立医学図書館（NLM）

Harnessing the Power of Nanoparticles for Antimicrobial Activity

The ever-present threat of bacterial infections necessitates innovative approaches to combat their spread. This study explores the potential of a biopolymeric gold nanocomposite, C-AuNp-Amp, as a potent antimicrobial agent. The researchers synthesized this nanocomposite by coupling ampicillin, a common antibiotic, with chitosan-capped gold nanoparticles. The antimicrobial activity and characteristics of this unique material were meticulously investigated.

A Promising New Weapon in the Fight Against Infections

The study revealed that C-AuNp-Amp exhibited significant antimicrobial activity, surpassing the efficacy of free ampicillin. This enhanced antimicrobial action is attributed to the increased surface area provided by the nanocomposite, which allows for greater interaction with bacterial cells. The researchers also found that by reducing the dosage of ampicillin, the nanocomposite can minimize potential side effects associated with conventional antibiotic treatment.

A New Frontier in Antimicrobial Therapy

This research holds promise for developing new and more effective antimicrobial therapies. The use of biopolymeric gold nanocomposites, such as C-AuNp-Amp, could revolutionize our approach to fighting infections. These nanomaterials offer a unique combination of antimicrobial properties and reduced side effects, presenting a significant advantage over traditional antibiotics.

Dr. Camel's Conclusion

Like a camel traversing the desert, seeking out precious oases, researchers are exploring new frontiers in medicine. This study highlights the exciting potential of nanotechnology for combating infections. By leveraging the power of nanoparticles, we may one day conquer even the most challenging bacterial foes.
Date :
  1. Date Completed 2010-07-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19929854

DOI: Digital Object Identifier

10.1042/BA20090198

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・Side Effects of ampicillin
SNS
PICO Info
in preparation
Languages

English

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