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[Effects of probucol, aspirin and atorvastatin combination therapy upon atherosclerosis].

Author: GengLi, LiZhen-Xiao, MengXiao-Ping, WangSu-Xiang, YinChun-Yuan, ZhangJi-Chang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antioxidant probucol significantly inhibits the generation of ox-LDL and MMP-9, leading to a decrease in plaque thickness and adverse events in patients with atherosclerosis. PAS therapy reduced the hospitalization rate, angina recurrence rate, myocardial infarction rate, and mortality rate compared to the control group.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate the effects of probucol, aspirin and atorvastatin (PAS) combination therapy upon atherosclerosis. METHODS: A total of 436 patients with coronary artery disease were selected and randomly divided into control group (aspirin 100 mg, atorvastatin 10 mg daily) and PAS group (a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19950575

データ提供：米国国立医学図書館（NLM）

Combating Atherosclerosis with a Powerful Combination Therapy

This research investigates the [Effects of Combination Therapy] on [Atherosclerosis]. It utilizes a [Randomized Controlled Trial] to compare the efficacy of [Probucol, Aspirin, and Atorvastatin] combination therapy to [Aspirin and Atorvastatin] alone. The authors demonstrate [The Beneficial Effects of Probucol] in reducing [Ox-LDL and MMP-9] levels. This study underscores the potential of [Antioxidant Therapy] in managing atherosclerosis.

A New Approach to Atherosclerosis Management

This research reveals that [Adding Probucol to Aspirin and Atorvastatin therapy improves treatment outcomes]. The study found a significant reduction in [Ox-LDL and MMP-9 levels] in the PAS group, highlighting the beneficial effects of Probucol. This finding suggests that [Probucol can play a crucial role in reducing the progression of atherosclerosis].

Protecting Your Heart Health

This research emphasizes the importance of [Adopting a healthy lifestyle] to prevent and manage atherosclerosis. It highlights the potential benefits of [Antioxidant-rich foods and supplements] in reducing oxidative stress and inflammation. This study suggests that [Early intervention and lifestyle modifications] can play a significant role in preventing and managing atherosclerosis.

Dr. Camel's Conclusion

This research reveals the potential of a powerful combination therapy in combating atherosclerosis. Just as a camel uses its strong legs to navigate the unforgiving desert, this study offers a new approach to managing this dangerous condition. This research emphasizes the importance of both pharmacological intervention and lifestyle modifications, encouraging us to adopt a proactive approach to heart health.

Date :
  1. Date Completed 2010-03-09
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19950575

DOI: Digital Object Identifier

19950575

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Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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