Effects of atorvastatin: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Atorvastatin appears to be more effective than simvastatin in reducing oxidative stress in patients with coronary heart disease. 9 . Atorvastatin, when combined with probucol, significantly inhibits the generation of oxidized LDL and MMP-9, reduces plaque thickness, and decreases the rate of adverse events in patients with atherosclerosis. 6 . Atorvastatin has shown better effects on lipid and inflammatory marker changes in patients with non-ST elevation acute coronary syndrome compared to rosuvastatin. 7 . Atorvastatin and simvastatin both lower cholesterol levels, but simvastatin leads to more significant changes in blood clotting parameters. 3 . Both atorvastatin and pravastatin reduce C-reactive protein (CRP) levels, but the effect of pravastatin is independent of lipid lowering while the effect of atorvastatin is associated with lipid lowering. 2 . Pitavastatin has shown better short-term and intermediate-term improvement in endothelial function than atorvastatin. 4 .

Benefits and Risks

Benefit Summary

Atorvastatin can potentially reduce oxidative stress, lower plaque thickness, and decrease the occurrence of adverse events. 6 . Atorvastatin may improve lipid and inflammatory marker levels in patients with non-ST elevation acute coronary syndrome. 7 . Atorvastatin may improve endothelial function in both short-term and intermediate-term. 4 . Atorvastatin lowers cholesterol levels. 3 . Atorvastatin can potentially lower C-reactive protein (CRP) levels. 2 .

Risk Summary

Atorvastatin may cause a reduction in testosterone levels. 10 . Atorvastatin may cause side effects such as muscle pain or fatigue. 9 . Atorvastatin may elevate liver enzymes. 3 .

Comparison Across Studies

Commonalities

All of these studies suggest that statins, like atorvastatin, might provide additional benefits beyond just lowering cholesterol, such as reducing oxidative stress. These studies also imply that the effects of statins may differ based on the specific drug used.

Differences

These studies differ in terms of their research subjects, study design, and assessed factors. For example, one study compares atorvastatin with simvastatin, while another study compares atorvastatin with rosuvastatin. Therefore, directly comparing results from these studies is difficult.

Consistency and Contradictions in Results

There are some contradictions within the results of these studies. For example, while one study suggests atorvastatin to be more effective than simvastatin, another study implies that their effects are similar. This could be due to differences in the studied populations or the research designs.

Cautions for Real-World Applications

The results of these studies suggest that atorvastatin might contribute to preventing and treating cardiovascular diseases. However, these studies don't prove that atorvastatin is safe and effective for everyone. Consulting with a doctor to assess the risks and benefits is necessary before considering atorvastatin use.

Limitations of Current Research

These studies are all relatively small and conducted over short periods. Thus, generalizing their findings requires caution. Furthermore, these studies haven't evaluated the long-term effects of atorvastatin.

Future Directions for Research

Further studies are needed to evaluate the long-term effects of atorvastatin. Additionally, larger studies are needed to assess the safety of atorvastatin.

Conclusion

The results of these studies suggest that atorvastatin might contribute to preventing and treating cardiovascular diseases. However, before considering atorvastatin use, it is crucial to consult with a doctor to evaluate the risks and benefits.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
9
1
1
0
9
1.

Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia.

Author: JoukhadarC, KleinN, PrinzM, SchrolnbergerC, VukovichT, WolztM, SchmettererL, DornerG T

cardiovascular event reduction

Statins may have beneficial effects beyond their lipid-lowering effects, potentially including reducing cardiovascular morbidity and mortality. However, further research is needed to determine whether all statins elicit these effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effect of atorvastatin and pravastatin on serum C-reactive protein.

Author: KentSteven M, FlahertyPatrick J, CoyleLouis C, MarkwoodThor T, TaylorAllen J

Improved lipid levels
Reduced CRP

High-dose atorvastatin and pravastatin both reduce C-reactive protein (CRP) levels. However, pravastatin's effect on CRP is independent of lipid-lowering efficacy, while atorvastatin's effect is at least partially dependent on lipid lowering.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

3.

Hemostatic effects of atorvastatin versus simvastatin.

Author: KadikoyluGurhan, YukselenVahit, YavasogluIrfan, BolamanZahit

Hypercholesterolemia treatment
Hemostatic effects

Atorvastatin was more effective than simvastatin in lowering lipid levels, while simvastatin had more significant effects on hemostatic parameters. Both drugs were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparisons of short- and intermediate-term effects of pitavastatin versus atorvastatin on lipid profiles, fibrinolytic parameter, and endothelial function.

Author: SakabeKoichi, FukudaNobuo, FukudaYamato, WakayamaKatsunori, NadaTeru, MorishitaSatofumi, ShinoharaHisanori, TamuraYoshiyuki

Endothelial function improvement
Lipid lowering

This study compared the short- and intermediate-term effects of pitavastatin and atorvastatin on lipid profiles, fibrinolytic parameters, and endothelial function. The results suggest that pitavastatin may be a better therapeutic choice for lipid-lowering and early alterations in endothelial function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
LetterA written message for communication and exchange of information between individuals.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: an 8-week, multicenter, randomized, open-label, dose-titration study in Korean patients with hypercholesterolemia.

Author: LeeSang Hak, ChungNamsik, KwanJun, KimDoo-Il, KimWon Ho, KimChee Jeong, KimHyun Seung, ParkSi Hoon, SeoHong Seog, ShinDong Gu, ShinYung Woo, ShimWan-Joo, AhnTae Hoon, Ho YunKyeong, YoonMyeong-Ho, ChaKwang-Soo, ChoiSi-Wan, HanSeong Wook, HyonMin Su

Lipid reduction
Quality of life improvement
Symptom reduction

Pitavastatin and Atorvastatin were found to be equally effective and well tolerated in lowering LDL-C levels in adults in Korea.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

[Effects of probucol, aspirin and atorvastatin combination therapy upon atherosclerosis].

Author: MengXiao-Ping, WangSu-Xiang, ZhangJi-Chang, LiZhen-Xiao, GengLi, YinChun-Yuan

Adverse event reduction
Atherosclerosis treatment
Plaque thickness reduction

Antioxidant probucol significantly inhibits the generation of ox-LDL and MMP-9, leading to a decrease in plaque thickness and adverse events in patients with atherosclerosis. PAS therapy reduced the hospitalization rate, angina recurrence rate, myocardial infarction rate, and mortality rate compared to the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

7.

[Non-ST-elevation acute coronary syndrome. Comparison of effects of atorvastatin and rosuvastatin on blood levels of lipids and markers of inflammation].

Author: KuznetsovaM A, VaulinN A, MasenkoV P, GratsianskiĭN A

Rosuvastatin inferior to atorvastatin

Rosuvastatin (10 mg/day) was slightly less effective than atorvastatin (40 mg/day) in reducing LDL-C levels in patients with non-ST elevation acute coronary syndrome (NSTEACS) during the first 14 days. Neither statin had a significant effect on inflammation markers within this timeframe.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

8.

Prevention of peri-procedural myocardial injury using a single high loading dose of rosuvastatin.

Author: CaySerkan, CagirciGoksel, SenNihat, BalbayYucel, DurmazTahir, AydogduSinan

Reduced myocardial injury

A single high loading dose of rosuvastatin reduced the incidence of peri-procedural myocardial necrosis and infarction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.

Author: LiJia, SunYan-Ming, WangLan-Feng, LiZhu-Qin, PanWei, CaoHong-Yan

Atorvastatin antioxidant

The study found that atorvastatin reduces oxidative stress more effectively than simvastatin in patients with coronary heart disease (CHD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Effect of atorvastatin on testosterone levels.

Author: ShawishMuhammad Ismail, BagheriBahador, MusiniVijaya M, AdamsStephen P, WrightJames M

PCOS treatment
Androgen reduction

Atorvastatin, a statin drug, may reduce testosterone and other androgen levels by inhibiting cholesterol synthesis, potentially causing negative effects. However, in the context of polycystic ovary syndrome (PCOS), reducing excessive androgen levels with atorvastatin could be beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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