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Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug: chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate.

Author: ChenLiqiang, HuLiming, LiChao, LiZelin, QiaoRenzhong, YangLin, ZengRong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed a nanosized nucleoside reverse transcriptase inhibitor (NRTI) monophosphate-polymer conjugate using d4T as a model NRTI. The conjugate nanoparticles were shown to have improved anti-HIV activity and reduced cytotoxicity compared to free d4T. This approach may improve therapy efficacy and reduce side effects in antiretroviral treatment.
Paper Details　
Original Abstract of the Article :
A novel approach to improve the antiviral efficacy of nucleoside reverse transcriptase inhibitors (NRTIs) and reduce their side effects was developed by constructing a nanosized NRTI monophosphate-polymer conjugate using d4T as a model NRTI. Firstly, a novel chitosan-O-isopropyl-5'-O-d4T monophospha...See full text at original site
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引用元：
https://doi.org/10.1016/j.bmc.2009.11.013

データ提供：米国国立医学図書館（NLM）

A Nanosized Approach to Anti-HIV Therapy: Chitosan-d4T Conjugate Nanoparticles

The fight against HIV continues to be a vital area of research, and scientists are constantly seeking innovative approaches to improve treatment efficacy. This study explores a novel strategy using chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate nanoparticles to deliver the anti-HIV drug d4T. The study delves into the synthesis, nanosizing, and in vitro drug release characteristics of this conjugate, offering a potential solution to address the limitations of current anti-HIV therapies.

Nanosized Conjugate Nanoparticles: Enhanced Drug Delivery and Anti-HIV Activity

The chitosan-d4T conjugate nanoparticles exhibit promising characteristics for targeted drug delivery and sustained release of the anti-HIV drug d4T. This approach could potentially improve the effectiveness of anti-HIV treatment while minimizing side effects.

Harnessing the Power of Nanotechnology for Anti-HIV Therapy

This research exemplifies the growing role of nanotechnology in developing effective and targeted anti-HIV therapies. The chitosan-d4T conjugate nanoparticles offer a promising avenue for improving drug delivery and potentially enhancing the effectiveness of anti-HIV treatment strategies.

Dr. Camel's Conclusion

The journey towards an effective HIV treatment continues, and nanotechnology is proving to be a valuable ally. This research demonstrates how chitosan-d4T conjugate nanoparticles could revolutionize anti-HIV therapy, paving the way for a more targeted and efficient approach.

Date :
  1. Date Completed 2010-04-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19959368

DOI: Digital Object Identifier

10.1016/j.bmc.2009.11.013

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