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Transport of phenylethylamine at intestinal epithelial (Caco-2) cells: mechanism and substrate specificity.

Author: BrandschMatthias, FischerWiebke, NeubertReinhard H H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the intestinal transport of beta-phenylethylamine (PEA). PEA is transported into Caco-2 cells by a highly active, saturable, H(+)-dependent process, which is distinct from known carriers for organic cations.
Paper Details　
Original Abstract of the Article :
This study was performed to characterize the intestinal transport of beta-phenylethylamine (PEA). Uptake of [(14)C]PEA into Caco-2 cells was Na(+)-independent but strongly stimulated by an outside directed H(+) gradient. At extracellular pH 7.5, the concentration-dependent uptake of PEA was saturabl...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2009.11.014

データ提供：米国国立医学図書館（NLM）

Unveiling the Transport Mechanism of Phenylethylamine at Intestinal Epithelial Cells

This research delves into the intricate world of intestinal transport, focusing on the movement of phenylethylamine (PEA) across the intestinal epithelial cells. Imagine a desert landscape where a vital substance, PEA, needs to travel across a series of membranes to reach its destination. The study uses Caco-2 cells, a model for studying intestinal transport, to investigate the mechanisms by which PEA is transported across the intestinal barrier. This research is like exploring the complex network of pathways that govern the movement of substances within the body.

PEA Transport: A Highly Active and H+-Dependent Process

The study reveals that PEA transport into Caco-2 cells is a highly active, saturable, and H+-dependent process. It's like a river flowing through the desert, driven by the force of a strong current. This study sheds light on the intricate mechanisms that govern the movement of PEA, a substance with important physiological roles in the body.

Understanding PEA Transport: A Key to Unlocking Its Potential

This study underscores the importance of understanding the mechanisms governing PEA transport across the intestinal barrier. It's like uncovering a hidden oasis in the desert, a key piece of knowledge that unlocks the potential for further exploration. This research provides valuable insights for understanding the fate of PEA in the body and its potential impact on human health.

Dr.Camel's Conclusion

This study provides a comprehensive understanding of the transport mechanism of phenylethylamine at intestinal epithelial cells. It highlights the complexity of intestinal transport and underscores the importance of understanding these mechanisms for developing new drugs and treatments. This research, like a map through the desert of intestinal transport, provides valuable knowledge for advancing our understanding of human physiology and disease.

Date :
  1. Date Completed 2010-05-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19962438

DOI: Digital Object Identifier

10.1016/j.ejpb.2009.11.014

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English

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