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Systematic review of trials using vasodilators in pulmonary arterial hypertension: why a new approach is needed.

Author: MacchiaAlejandro, MarchioliRoberto, MarfisiRosamaria, RichStuart, ScaranoMarco, TavazziLuigi, TognoniGianni

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis examined the effects of various treatments for pulmonary hypertension on 6-minute walk distance, hemodynamics, and survival.
Paper Details　
Original Abstract of the Article :
In a previous meta-analysis on the approved treatments for pulmonary hypertension, we reported that all therapies caused small changes in 6-minute walk distance over a short period, with minimal effects on hemodynamics and no effect on survival. Since that last review, 10 new clinical trials with ab...See full text at original site
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引用元：
https://doi.org/10.1016/j.ahj.2009.11.028

データ提供：米国国立医学図書館（NLM）

Vasodilators for Pulmonary Arterial Hypertension: A New Approach Is Needed

This research delves into the complex world of pulmonary arterial hypertension (PAH), a serious condition characterized by high blood pressure in the arteries of the lungs. The study examines the effectiveness of vasodilators, medications that widen blood vessels, as a treatment for PAH. They review previous meta-analyses and new clinical trials involving over 1,500 patients to assess the efficacy of vasodilators in improving both short-term and long-term outcomes.

Limited Effectiveness of Vasodilators in PAH

The findings reveal that while vasodilators may provide some short-term benefits in terms of walking distance, they have minimal impact on hemodynamics and no effect on survival. This suggests that a new approach is needed to effectively address this challenging condition.

The Need for Innovative Treatments

The study highlights the need for a fresh perspective on PAH treatment. It's like searching for a hidden spring in a parched desert. We need to explore new therapeutic strategies that can truly make a difference in the lives of individuals with PAH.

Dr.Camel's Conclusion

This research underscores the critical need for innovative treatments for PAH. It's a reminder that we must constantly strive to find new ways to combat challenging conditions. This study serves as a beacon, guiding us towards a future where more effective treatments are available for PAH.

Date :
  1. Date Completed 2010-03-03
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20152223

DOI: Digital Object Identifier

10.1016/j.ahj.2009.11.028

Related Literature

Article Analysis
・Effective treatment of pulmonary hypertension
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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