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Sex steroids to maintain cognitive function in women after the menopause: a meta-analyses of treatment trials.

Author: BandelowStephan, HogervorstEef

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Whether estrogen treatment after menopause improves cognitive function in women is still debated. While research shows estrogen can have positive effects on the aging brain and observational studies show a lower risk of dementia in women who took estrogen around menopause, large clinical trials have shown negative effects of long-term estrogen use in older women. This review found that the age of women or the time since menopause when treatment began did not affect outcomes, and it didn't matter if women had symptoms or not. However, the length of treatment did matter, with longer studies showing more negative effects and short-term studies (less than 4 months) showing mainly positive effects. Estrogen combined with progesterone also had negative effects. More research is needed to determine if short-term treatment or intermittent treatment could have long-term benefits for women with menopausal symptoms.
Paper Details　
Original Abstract of the Article :
It is still debated whether estrogen treatment after the menopause could result in improved cognitive function in women. This debate is based on many animal and cell culture data showing that estrogens can positively affect the aging brain. Observational data also show a halved risk of dementia in w...See full text at original site
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引用元：
https://doi.org/10.1016/j.maturitas.2010.02.005

データ提供：米国国立医学図書館（NLM）

Estrogen Treatment After Menopause: A Complex Puzzle

The role of estrogen in maintaining cognitive function after menopause remains a subject of ongoing debate. This study delves into the complex relationship between estrogen treatment and cognitive function in postmenopausal women. The authors conducted a meta-analysis of 36 randomized treatment trials, examining various factors, including age, duration of treatment, and symptom status, to determine the effects of estrogen therapy on cognitive function. The results suggest a complex picture, with no clear-cut answers.

Contradictory Evidence Requires Further Investigation

The study revealed that, contrary to expectations, age and duration of treatment did not significantly affect the outcome of estrogen therapy. However, longer treatment durations were associated with more negative effects, while short-term treatment showed mostly positive effects. This contradictory evidence emphasizes the need for more research to elucidate the long-term effects of estrogen treatment on cognitive function.

Navigating the Uncertainties of Hormone Therapy

Navigating the complex world of hormone therapy requires careful consideration. The study suggests that estrogen treatment may have both positive and negative effects on cognitive function, depending on various factors. It is crucial to discuss your individual needs and risks with a qualified healthcare professional before making any decisions regarding hormone therapy.

Dr.Camel's Conclusion

The desert of hormone therapy is filled with shifting sands and hidden oases. While estrogen treatment shows promise for some, its long-term effects remain shrouded in mystery. Like the ancient caravans that navigated these treacherous landscapes, we must approach hormone therapy with caution, relying on the guidance of experienced healthcare professionals. Further research is necessary to illuminate the path forward and unlock the secrets of this enigmatic oasis.

Date :
  1. Date Completed 2010-09-28
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

20202765

DOI: Digital Object Identifier

10.1016/j.maturitas.2010.02.005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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