Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers.

Author: ChoJoo-Youn, JangIn-Jin, KimBo-Hyung, KimJung-Ryul, KimKyu-Pyo, LeeKyung-Hee, LeeYong-Oh, LimKyoung Soo, ShinSang-Goo, YoonSeo Hyun, YuKyung-Sang

Paper Details 
Original Abstract of the Article :
Ginkgo biloba extract is an herbal medicine used in the treatment of vascular disorders that may be coadministered with antiplatelet agents such as ticlopidine. Regulatory authorities requested evaluation of the pharmacodynamic and pharmacokinetic interactions between these entities, according to th...See full text at original site
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引用元:
https://doi.org/10.1016/j.clinthera.2010.01.027

データ提供:米国国立医学図書館(NLM)

Investigating the Effects of Ginkgo Biloba Extract on Ticlopidine

The field of medicine constantly seeks to understand the interplay of different medications, particularly when it comes to traditional remedies and modern pharmaceuticals. This study, a single-dose crossover study in healthy Korean male volunteers, delves into the effects of Ginkgo biloba extract, an herbal medicine used for vascular disorders, on ticlopidine, an antiplatelet agent. The researchers employed a rigorous approach with two periods, two treatments, and two sequences to examine both pharmacodynamic and pharmacokinetic interactions between these substances. Their goal was to assess the potential for interactions, prompted by regulatory authorities' guidelines for fixed-dose combination formulations in Korea.

Unveiling the Dynamics of Interaction

The study provides valuable insights into the potential interplay between Ginkgo biloba extract and ticlopidine. The findings can help healthcare professionals make informed decisions about co-administration of these drugs, ensuring patient safety and optimal therapeutic outcomes.

Navigating the Desert of Medications

As we journey through the vast desert of medications, it's crucial to understand how different compounds interact with each other. This study sheds light on the potential interactions between Ginkgo biloba extract and ticlopidine, helping us navigate this complex landscape with greater awareness.

Dr. Camel's Conclusion

This study emphasizes the importance of understanding the interactions between traditional and modern medicines. It's like navigating a vast desert – knowing the terrain and potential hazards is crucial for a safe and successful journey. By shedding light on the interplay between Ginkgo biloba extract and ticlopidine, this study offers valuable guidance for healthcare professionals, enabling them to better navigate the complex world of medications.

Date :
  1. Date Completed 2010-05-28
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

20206795

DOI: Digital Object Identifier

10.1016/j.clinthera.2010.01.027

Related Literature

SNS
PICO Info
in preparation
Languages

English

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