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Clorazepate: double blind crossover comparison of a single nightly dose with diazepam thrice daily in anxiety.

Author: CurryS H, DeanB C, MagnusR V

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Clorazepate, an anxiolytic, was as effective as diazepam in treating mild to moderate anxiety. Clorazepate had a significantly lower incidence and frequency of side effects than diazepam.
Paper Details　
Original Abstract of the Article :
In a double blind cross-over study in 40 patients with mild to moderate anxiety, clorazepate 15 mg at bedtime was as effective as diazepam on global rating and slightly superior on target symptom assessment. There was a significantly higher incidence and frequency of side effects during diazepam tre...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20284

データ提供：米国国立医学図書館（NLM）

Clorazepate: A Steady and Reliable Anxiolytic

This study, published in 1979, explores the effectiveness of clorazepate, an anxiolytic medication used to manage anxiety disorders. The researchers compared the effects of clorazepate to those of diazepam, another common anxiolytic, using a double-blind, crossover trial involving 40 patients with mild to moderate anxiety. The findings, like a well-mapped caravan route, provide insights into the effectiveness and side effects of these medications.

Clorazepate: A Single Dose Solution

The study found that clorazepate, administered once daily at bedtime, was as effective as diazepam, given three times a day, in reducing anxiety symptoms. Additionally, clorazepate was associated with fewer side effects. These findings suggest that clorazepate, like a single oasis providing a steady source of water, might offer a more convenient and manageable treatment option for anxiety.

Navigating the Anxiolytic Desert

It is important to remember that every camel reacts differently to the desert heat. The right anxiolytic for you will depend on your individual needs and health history. Always consult with a healthcare professional to determine the most suitable treatment for your anxiety.

Dr. Camel's Conclusion

This study, like a caravan traveling through a challenging landscape, provides valuable insights into the effectiveness of clorazepate as an anxiolytic. The research highlights the potential of clorazepate to offer a convenient and effective treatment option for anxiety, offering a beacon of hope for those seeking relief.
Date :
  1. Date Completed 1977-11-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20284

DOI: Digital Object Identifier

20284

Related Literature

Article Analysis
・Side Effects of clorazepate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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