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Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review.

Author: MacQueenGlenda M, Van LieshoutRyan J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis examined the efficacy and safety of mood stabilizers for acute bipolar depression. Eighteen studies with 4105 participants were included. Mood stabilizers were more effective than placebo in achieving response and remission. Combination therapy was not statistically superior to monotherapy. Further research on mood stabilizers is needed.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Although people with bipolar disorder spend more time in a depressed than manic state, little evidence is available to guide the treatment of acute bipolar depression. AIMS: To compare the efficacy, acceptability and safety of mood stabiliser monotherapy with combination and antidepress...See full text at original site
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引用元：
https://doi.org/10.1192/bjp.bp.108.057612

データ提供：米国国立医学図書館（NLM）

Mood Stabilizers for Bipolar Depression: Navigating the Desert of Mental Health Treatment

The journey through the desert of [bipolar disorder] can be a challenging one, with [depression] being a frequent and debilitating companion. This study explores the effectiveness of [mood stabilizers] in treating acute bipolar depression. The authors conducted a systematic review and meta-analysis of randomized controlled trials to determine the efficacy and safety of these medications.

The Oasis of Mood Stabilization: A Promising Approach

The study found that mood stabilizers showed moderate efficacy in treating acute bipolar depression, with a significant improvement in response and remission rates compared to placebo. This finding suggests that mood stabilizers can be a valuable tool in managing this complex condition.

Navigating the Desert of Bipolar Depression: Hope for a Brighter Future

This research highlights the potential of mood stabilizers in providing relief for individuals experiencing acute bipolar depression. It emphasizes the need for continued research to better understand the long-term efficacy and safety of these medications.

Dr. Camel's Conclusion

This study provides valuable insights into the treatment of acute bipolar depression. The findings suggest that mood stabilizers offer a promising therapeutic approach, though further research is needed to optimize their use and address potential side effects.
Date :
  1. Date Completed 2010-05-14
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20357301

DOI: Digital Object Identifier

10.1192/bjp.bp.108.057612

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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