Degree of viral decline early in treatment predicts sustained virological response in HCV-HIV coinfected patients treated with peginterferon alfa-2a and ribavirin.

Author: CarosiG, DepamphilisJ, DieterichD T, RockstrohJ, Rodriguez-TorresM, TorrianiF

Paper Details 
Original Abstract of the Article :
BACKGROUND: In hepatitis C virus (HCV) monoinfection, the on-treatment virological response at Weeks 4 and 12 is a strong predictor of treatment outcomes. METHODS: In a retrospective analysis, we examined these responses in 289 HIV-HCV coinfected patients treated with Peg-IFN alfa-2a /ribavirin for...See full text at original site
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引用元:
https://doi.org/10.1310/hct1101-1

データ提供:米国国立医学図書館(NLM)

Early Viral Decline: A Compass in the Desert of HCV-HIV Coinfection

Hepatitis C virus (HCV) infection, like a persistent sandstorm, can severely impact health, especially when co-infected with HIV. This research explores the predictive value of early viral decline in HCV-HIV coinfected patients undergoing treatment with peginterferon alfa-2a and ribavirin. The study retrospectively analyzed data from a large randomized clinical trial to identify predictors of sustained virological response.

Early Viral Decline: A Guiding Star for Success

The findings demonstrated that early viral decline, like a guiding star in the desert, was strongly associated with sustained virological response in HCV-HIV coinfected patients. This emphasizes the importance of monitoring viral load during treatment and adjusting therapies as needed to achieve optimal outcomes. It's like adjusting the caravan's route based on the desert's changing conditions.

Navigating the Challenges of Coinfection

This research highlights the complexities of treating HCV-HIV coinfection. The study reinforces the need for early intervention and individualized treatment strategies to optimize outcomes for these patients. It's a reminder that navigating the challenges of coinfection requires a comprehensive approach, like carefully selecting a camel caravan equipped to handle the unique terrain of the desert.

Dr.Camel's Conclusion

This research provides valuable insights into the treatment of HCV-HIV coinfection. Early viral decline is a significant predictor of sustained virological response, emphasizing the importance of monitoring viral load and adjusting treatment strategies as needed to achieve optimal outcomes for these patients.

Date :
  1. Date Completed 2010-05-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20400406

DOI: Digital Object Identifier

10.1310/hct1101-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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