Cyclosporine trough levels and its side effects in kidney transplant recipients.

Author: HamiMaryam, MojahediMohammad Javad, NaghibiMasih, ShakeriMohammad Taghi, SharifipourFarzaneh

Paper Details 
Original Abstract of the Article :
INTRODUCTION: Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it is associated with side effects, some of which are dose-dependent. We evaluated association between cyclosporine trough level and its side effects. MATERIALS AND METHODS: In 50 kidney transplant r...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/20404428

データ提供:米国国立医学図書館(NLM)

Cyclosporine Trough Levels and Side Effects in Kidney Transplant Recipients

Kidney transplant recipients rely heavily on cyclosporine for immunosuppression, but the drug can come with side effects, some of which are dose-dependent. This study aimed to uncover the relationship between cyclosporine trough levels and side effects in kidney transplant recipients. The researchers analyzed data from 50 recipients, meticulously tracking their cyclosporine levels, blood glucose, and creatinine over a period of six months. They also monitored for common side effects like hypertension, hyperglycemia, hand tremor, and headache. Their analysis sought to establish a clear link between cyclosporine levels and these side effects. The study found no direct association between cyclosporine levels and side effects. This discovery is significant, as it helps physicians navigate the complexities of immunosuppression while minimizing the risk of adverse reactions.

The Mystery of Cyclosporine Side Effects

The study's findings challenge the conventional assumption that cyclosporine trough levels directly correlate with the occurrence of side effects. The researchers observed that drug side effects were not significantly influenced by cyclosporine levels, suggesting a more complex interplay of factors at play.

Health Implications and Practical Applications

Imagine navigating a vast desert, where the dunes shift and change constantly. Similarly, the management of kidney transplant recipients requires careful observation and a nuanced understanding of the interplay between medications and individual responses. This study provides valuable insights for physicians, allowing them to tailor treatment strategies to each patient's unique needs and avoid unnecessary side effects.

Dr.Camel's Conclusion

The study's findings serve as a reminder that the human body is a complex system, and medication responses can vary significantly. By shedding light on the unpredictable nature of cyclosporine side effects, this research empowers physicians to approach immunosuppression with caution and individualized care.

Date :
  1. Date Completed 2010-11-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20404428

DOI: Digital Object Identifier

211/188

Related Literature

SNS
PICO Info
in preparation
Languages

English

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