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Manifestations of severe vitamin D deficiency in adolescents: effects of intramuscular injection of a megadose of cholecalciferol.

Author: AdelAshraf, AlaliMaryam, Aziz BedairElsaid M, SolimanAshraf T, WagdyMagda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that a large dose of vitamin D (cholecalciferol) was effective in treating severe vitamin D deficiency in adolescents for 3 months, but not for 6 months. Most patients showed improvement in symptoms after 3 months. Blood levels of calcium, phosphate, and parathyroid hormone returned to normal after 3 months. X-ray imaging of long bones was helpful for diagnosis and monitoring.
Paper Details　
Original Abstract of the Article :
We recorded the manifestations of severe vitamin D deficiency (VDD) in 40 adolescents before and 3 and 6 months after treatment with a mega dose of cholecalciferol (10 000 IU kg(-1), max 600 000 IU). Significant improvement of symptoms related to VDD was reported in 34/40. Three months after the inj...See full text at original site
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引用元：
https://doi.org/10.1093/tropej/fmq028

データ提供：米国国立医学図書館（NLM）

Restoring Balance: Addressing Severe Vitamin D Deficiency in Adolescents

Vitamin D deficiency, a widespread health concern, can manifest in various ways. This study investigates the [effects of a megadose of cholecalciferol on adolescents with severe vitamin D deficiency]. The researchers followed 40 adolescents with severe VDD for 6 months after a single intramuscular injection of cholecalciferol. They found that a megadose of cholecalciferol was effective in improving symptoms and restoring normal serum calcium, phosphate, alkaline phosphatase, and parathormone levels within 3 months. However, the improvement was not sustained for 6 months.

A Vital Nutrient: Addressing Vitamin D Deficiency in Adolescents

This study underscores the importance of [screening for vitamin D deficiency] and providing appropriate treatment, especially in adolescents. While a single megadose of cholecalciferol can provide rapid improvement, it's crucial to maintain adequate vitamin D levels through ongoing supplementation or dietary modifications. This research emphasizes the need for individualized approaches to managing vitamin D deficiency based on age, lifestyle, and individual needs.

Navigating the Vitamin D Desert: Ensuring Adequate Intake and Monitoring Levels

This study highlights the importance of [maintaining adequate vitamin D levels] throughout life. While sun exposure is a natural source of vitamin D, it's not always feasible or safe, especially in certain geographic locations. Therefore, it's crucial to consider dietary sources of vitamin D or supplements to ensure adequate intake. Regular monitoring of vitamin D levels is essential for identifying deficiencies and optimizing treatment strategies.

Dr. Camel's Conclusion

Vitamin D, a vital nutrient, plays a crucial role in maintaining our health. This study reminds us that addressing vitamin D deficiency, particularly in adolescents, requires a comprehensive approach. Like a camel traversing the desert, we must be mindful of our vitamin D levels and seek appropriate guidance to ensure a well-nourished and vibrant journey.
Date :
  1. Date Completed 2011-12-09
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

20427425

DOI: Digital Object Identifier

10.1093/tropej/fmq028

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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