Effective treatment of vision impairment and blindness: A Synthesis of Findings from 48 Studies

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Original Abstract of the Article

Major Research Findings

Vitamin D deficiency is a widespread problem globally, including Pakistan, and is linked to a wide range of health issues. 35 The prevalence of vitamin D deficiency is concerning, with potential implications for various clinical diseases.

The vitamin D receptor is present in nearly all cells in the body, suggesting a broader role for vitamin D beyond bone health. 20 While observational data shows a connection between vitamin D levels and chronic diseases like metabolic, cardiovascular, and neoplastic disorders, more large-scale studies are needed to establish definitive benefits of vitamin D supplementation.

Intramuscular injections of high-dose vitamin D3 have shown promise in treating severe vitamin D deficiency in adolescents. 15 The study reported improvements in symptoms related to vitamin D deficiency after 3 months, but the effect wasn't sustained for 6 months. This highlights the need for ongoing monitoring and potential for repeated doses.

Vitamin D3 has been proven more effective than vitamin D2 in raising serum 25-hydroxyvitamin D levels. 7 This suggests that vitamin D3 might be a preferable choice for supplementation.

The optimal dose of vitamin D for disease prevention in older adults appears to be around 4000 IU daily. 32 This dosage is important for achieving blood levels linked to lower disease risks.

Vitamin D supplementation might be beneficial for managing secondary hyperparathyroidism in hemodialysis patients. 31 Combining cholecalciferol with paricalcitol, an active vitamin D analogue, could offer additional benefits.

In postmenopausal women with osteoporosis, high doses of synthetic calcitriol have been studied as a treatment option. 2 Further research is necessary to fully understand its efficacy and safety profile.

treatmentまとめ

15 This study used intramuscular injections of high-dose vitamin D3 to treat adolescents with severe vitamin D deficiency.

22 This study compared high doses of oral and intramuscular cholecalciferol in treating vitamin D deficiency.

30 This study evaluated different dose-response relationships of vitamin D3 supplementation.

Benefits and Risks

Benefit Summary

Vitamin D supplementation might offer benefits in terms of bone health, immune function, cardiovascular health, metabolism, and nerve function. It could also potentially help prevent or manage certain chronic conditions.

Risk Summary

Excessive intake of vitamin D can lead to hypercalcemia (high calcium levels in the blood), kidney stones, and other issues. Some people might experience digestive problems or allergic reactions.

Comparison of Studies

Commonalities

Many studies have shown that vitamin D supplementation increases blood levels of vitamin D. Research consistently suggests potential benefits in managing osteoporosis.

Differences

Studies vary in terms of methods, target populations, supplementation approaches, dosage, duration, and specific outcomes measured. Therefore, comparing results can be complex.

Consistency and Contradictions in Findings

The research findings on vitamin D supplementation demonstrate both consistency and contradictions. While some studies have found benefits for various health conditions, other studies have shown no significant effects. These discrepancies could be attributed to differences in study design, participants, supplementation protocols, and other factors.

Practical Applications and Precautions

While vitamin D supplementation can be beneficial for many people, it is crucial to consult with a doctor before starting any supplementation. Individuals with existing health conditions should discuss the potential risks and benefits with their healthcare provider.

Limitations of Current Research

There is still a need for more research on vitamin D supplementation, particularly long-term effects. Optimal dosages and administration methods are not yet fully established.

Future Research Directions

Future research should focus on long-term studies to investigate the impact of vitamin D supplementation. More studies are needed to examine the efficacy of vitamin D supplementation in preventing or treating specific diseases.

Conclusion

Vitamin D plays a crucial role in maintaining overall health. Supplementing vitamin D might offer benefits for various conditions, but it's crucial to consult a doctor before making any changes to your supplement intake. More research is necessary to fully understand the long-term effects and optimal usage of vitamin D.

Treatment List

Intramuscular injections of high-dose vitamin D3

High doses of oral and intramuscular cholecalciferol

Oral vitamin D3 supplementation

Literature analysis of 48 papers
Positive Content
47
Neutral Content
1
Negative Content
0
Article Type
39
5
5
6
48
1.

Vitamin D supplements and 25-hydroxy vitamin D concentrations in the elderly.

Author: MacLennanW J, HamiltonJ C

Increased 25-OHD levels
Prevent osteomalacia

A study of long-stay geriatric patients found that a daily dose of 500 IU vitamin D significantly increased 25-OHD levels after two months, especially when initial levels were low.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Treatment of postmenopausal osteoporosis with high doses of synthetic calcitriol. A randomized controlled study.

Author: GallagherJ C, GoldgarD

Osteoporosis treatment

The treatment of postmenopausal osteoporotic women with synthetic calcitriol for 2 years was associated with increases in spine density and total body calcium.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Vitamin D metabolism in osteoporotic women during treatment with estrogen, an anabolic steroid, or calcitonin.

Author: HartwellD, HassagerC, OvergaardK, RiisB J, PødenphantJ R, ChristiansenC

Positive skeletal effects

A study of 119 postmenopausal women with osteoporotic fractures found that estradiol and norethisterone acetate, nandrolone decanoate, and salmon calcitonin did not significantly affect vitamin D metabolites.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.

Author: ChristiansenC, RodbroP, SjöO

Reduced seizure frequency

A study of 23 patients with epilepsy found that vitamin D treatment reduced the frequency of seizures compared to placebo, even though there were no changes in blood calcium or magnesium levels. The study suggests that vitamin D may be beneficial in preventing seizures in people with epilepsy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The effect of different vitamin D treatments on serum vitamin D levels in early postmenopausal women.

Author: RiisB, ChristiansenC, RodbroP

Increased calcium absorption

A study of 29 menopausal women found that vitamin D3, but not 1,25(OH)2D3/l alpha-OHD3, significantly increased serum levels of 24,25(OH)2D and 25OHD3, while serum 1,25(OH)2D levels remained unchanged.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Annual high-dose vitamin D prophylaxis in Asian immigrants.

Author: StephensW P, KlimiukP S, BerryJ L, MawerE B

Effective prophylaxis
Higher compliance

A study of vitamin D-depleted Asians found that a single autumn dose of 2.5 mg ergocalciferol effectively prevented vitamin D deficiency during the winter.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2.

Author: TrangH M, ColeD E, RubinL A, PierratosA, SiuS, ViethR

This study found that vitamin D3 was more effective at increasing blood levels of vitamin D than vitamin D2. After taking 4000 IU of either vitamin D2 or D3 daily for 14 days, participants taking vitamin D3 had a 1.7 times greater increase in vitamin D levels than those taking vitamin D2. This suggests that the assumption that vitamin D2 and D3 are equally effective may be incorrect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.

Author: Barger-LuxM J, HeaneyR P, DowellS, ChenT C, HolickM F

In a study of 116 healthy men, different doses of vitamin D3, 25(OH)D3, and 1,25(OH)2D3 were given for short periods of time. Vitamin D3 increased blood levels of vitamin D and 25(OH)D, while 25(OH)D3 only increased blood levels of 25(OH)D. 1,25(OH)2D3 increased blood levels of 1,25(OH)2D. These findings suggest that taking 400 IU of vitamin D3 daily for 8 weeks would increase blood vitamin D levels by 9 nmol/l and 25(OH)D levels by 11 nmol/l. Taking 20 micrograms of 25(OH)D3 daily for 4 weeks would increase blood 25(OH)D levels by 94 nmol/l. Taking 0.5 micrograms of 1,25(OH)2D3 daily for 2 weeks would increase blood 1,25(OH)2D levels by 17 pmol/l.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Chronotherapy of high-dose active vitamin D3 in haemodialysis patients with secondary hyperparathyroidsm: a repeated dosing study.

Author: TsuruokaShuichi, WakaumiMichi, SugimotoKoichi, SaitoTetsuo, FujimuraAkio

Renal osteodystrophy treatment
Hypercalcemia

Renal osteodystrophy is a serious bone problem for people with kidney failure. While vitamin D3 is often used to treat this condition, high calcium levels can sometimes lead to the treatment being stopped. This study investigates if the effectiveness and safety of vitamin D3 are affected by when it is given during repeated treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Topical paricalcitol (19-nor-1 alpha,25-dihydroxyvitamin D2) is a novel, safe and effective treatment for plaque psoriasis: a pilot study.

Author: DurakovicC, RayS, HolickM F

Psoriasis treatment

New treatments are still needed for psoriasis. Topical vitamin D compounds have proven safe and effective for psoriasis. Paricalcitol, a new type of vitamin D, has been developed to prevent a condition affecting the parathyroid glands in people with kidney failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

[Vitamin D and fractures: a systematic review].

Author: ViapianaO, GattiD, RossiniM, IdolazziL, FracassiE, AdamiS

Improved vitamin D deficiency treatment
Vitamin D deficiency

Vitamin D deficiency is a problem, especially in Southern Europe and older adults. It can contribute to bone and muscle problems like osteoporosis, osteomalacia, and muscle weakness, increasing the risk of falls and fractures. Studies show that vitamin D treatment can reduce fracture risk, although some recent studies with methodological issues have questioned this. Overall, treating vitamin D deficiency in high-risk people is cost-effective, but taking the vitamin as prescribed is crucial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Italian

14.

Vitamin D compounds for people with chronic kidney disease requiring dialysis.

Author: PalmerSuetonia C, McGregorDavid O, CraigJonathan C, ElderGrahame, MacaskillPetra, StrippoliGiovanni Fm

CKD treatment
Increased calcium
Increased phosphorus

Guidelines recommend vitamin D for managing chronic kidney disease (CKD) by lowering parathyroid hormone levels, but this treatment may increase phosphorus and calcium levels, which have been linked to higher death rates in observational studies. However, these studies also suggest that vitamin D treatment may be linked to lower death rates in CKD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Manifestations of severe vitamin D deficiency in adolescents: effects of intramuscular injection of a megadose of cholecalciferol.

Author: SolimanAshraf T, AdelAshraf, WagdyMagda, AlaliMaryam, Aziz BedairElsaid M

VDD treatment

This study found that a large dose of vitamin D (cholecalciferol) was effective in treating severe vitamin D deficiency in adolescents for 3 months, but not for 6 months. Most patients showed improvement in symptoms after 3 months. Blood levels of calcium, phosphate, and parathyroid hormone returned to normal after 3 months. X-ray imaging of long bones was helpful for diagnosis and monitoring.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Economic analysis of cinacalcet in combination with low-dose vitamin D versus flexible-dose vitamin D in treating secondary hyperparathyroidism in hemodialysis patients.

Author: ShiremanTheresa I, AlmehmiAmmar, WetmoreJames B, LuJohn, PregenzerMark, QuarlesL Darryl

SHPT treatment

The ACHIEVE trial compared the effectiveness of cinacalcet plus low-dose vitamin D to vitamin D alone in treating secondary hyperparathyroidism (SHPT). This study examines the cost implications of these treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Paricalcitol versus ergocalciferol for secondary hyperparathyroidism in CKD stages 3 and 4: a randomized controlled trial.

Author: KovesdyCsaba P, LuJun L, MalakauskasSandra M, AndressDennis L, Kalantar-ZadehKamyar, AhmadzadehShahram

Paricalcitol SHPT

Paricalcitol was more effective than ergocalciferol in decreasing parathyroid hormone (PTH) levels in patients with chronic kidney disease (CKD) stages 3 or 4 with vitamin D deficiency and secondary hyperparathyroidism (SHPT).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass--a randomized controlled 1-year trial.

Author: GrimnesG, JoakimsenR, FigenschauY, TorjesenP A, AlmåsB, JordeR

Improved bone mineral density

While vitamin D is commonly used to treat osteoporosis, the ideal dose is unclear. This one-year study of 297 women aged 50-80 found that a high dose of vitamin D (6,500 IU/day) did not improve bone density in the hip and spine more than a standard dose (800 IU/day).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency.

Author: DiamondT, WongY K, GolombickT

Treatment of vitamin D deficiency

Taking 5,000 IU of vitamin D daily for three months was more effective in raising vitamin D levels in the blood than taking 2,000 IU daily. An ideal blood vitamin D level was found to be 63.8 nmol/L. After three months of vitamin D supplementation, muscle strength also improved.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

Author: RosenClifford J, AdamsJohn S, BikleDaniel D, BlackDennis M, DemayMarie B, MansonJoAnn E, MuradM Hassan, KovacsChristopher S

Vitamin D benefits

This review examines the potential benefits of vitamin D for various body functions beyond bone health. While many studies suggest a connection between vitamin D and conditions like muscle and bone health, heart disease, cancer, and metabolism, there is a lack of large and long-term clinical trials. More research is needed to confirm the benefits of vitamin D in preventing and treating these conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

25-Hydroxyvitamin D response to cholecalciferol supplementation in hemodialysis.

Author: ArmasLaura A G, AndukuriRadha, Barger-LuxJanet, HeaneyRobert P, LundRichard

Improved 25-hydroxyvitamin D levels
Vitamin D treatment

Weekly cholecalciferol (10,333 IU) administration in patients on chronic hemodialysis produces a steady state in 25-hydroxyvitamin D of approximately 24 ng/ml.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT.

Author: ZabihiyeganehMozhdeh, JahedAdel, NojomiMarzieh

Treatment of hypovitaminosis D

Vitamin D deficiency is widespread. This study compares the effectiveness and practicality of two high-dose treatments for vitamin D deficiency: an injection of vitamin D (intramuscular cholecalciferol) and taking high doses of vitamin D by mouth (oral cholecalciferol). The study also looks at how long the effects of each treatment last.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A 250 μg/week dose of vitamin D was as effective as a 50 μg/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 μg raised the risk of hypercalciuria.

Author: ZwartSara R, ParsonsHoward, KimlinMichael, InnisSheila M, LockeJames P, SmithScott M

Vitamin D status improvement
Hypercalciuria

This study compared different ways of taking vitamin D supplements (daily, weekly, or weekly/monthly) in healthy adults. Taking vitamin D weekly (up to 10,000 IU) was as effective as daily doses in raising vitamin D levels and didn't increase the risk of high calcium in the urine. However, weekly doses of 50,000 IU were associated with higher calcium levels in the urine, especially in people with a BMI over 26.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

24.

Long-term bioavailability after a single oral or intramuscular administration of 600,000 IU of ergocalciferol or cholecalciferol: implications for treatment and prophylaxis.

Author: CiprianiCristiana, RomagnoliElisabetta, PepeJessica, RussoStefania, CarlucciLuciano, PiemonteSara, NiedduLuciano, McMahonDonald J, SinghRavinder, MinisolaSalvatore

Serum 25(OH)D increase

Oral ergocalciferol (D2) and cholecalciferol (D3) were more effective than intramuscular doses in increasing serum 25-hydroxyvitamin D (25(OH)D) levels, but both were rapidly metabolized. Oral D2 led to a decrease in 1,25-dihydroxyvitamin D (1,25(OH)2D) and an increase in 1,25-dihydroxyvitamin D2 (1,25(OH)2D2) levels.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Change in vitamin d levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings.

Author: HaversFiona P, DetrickBarbara, CardosoSandra W, BerendesSima, LamaJavier R, SugandhavesaPatcharaphan, MwelaseNoluthando H, CampbellThomas B, GuptaAmita,

Vitamin D
HIV

Vitamin D plays a role in the immune system, and low vitamin D levels have been linked to poorer outcomes in people with HIV. Recent research has found that HIV medications can lower vitamin D levels, but this research has been done primarily in North America and Europe. This study aims to investigate this link in a different population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Efficacy of strontium ranelate in combination with a D-hormone analog for the treatment of postmenopausal osteoporosis.

Author: AbboskhujaevaLola S, IsmailovSaydiganikhodja I, AlikhanovaNodira M

Bone density increase
Fall risk reduction

Strontium ranelate and alfacalcidol combination therapy improved bone quality, fall risk, and markers of bone turnover to a greater extent than strontium ranelate alone in patients with established osteoporosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Moderate amounts of vitamin D3 in supplements are effective in raising serum 25-hydroxyvitamin D from low baseline levels in adults: a systematic review.

Author: WhitingSusan J, BonjourJean-Philippe, PayenFlore Dontot, RousseauBrigitte

Vitamin D status

There's debate about how much vitamin D is enough, and whether food or supplements can make a difference. This study looked at the impact of small daily doses of vitamin D (5-20 micrograms) on blood vitamin D levels. It found that for every microgram of vitamin D taken, vitamin D levels increased by 2 nanomoles per liter. The study also found that taking an additional 10 micrograms of vitamin D daily was beneficial for those with low vitamin D levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis.

Author: MehrotraAnita, LeungWai-Yin, JosonTannia

Hemodialysis treatment

Vitamin D deficiency is common in people who receive dialysis for kidney failure. While most patients receive activated vitamin D to prevent bone problems, there's variability in how vitamin D deficiency is screened and treated. This study examines whether taking vitamin D supplements (D2 or D3) in addition to activated vitamin D is beneficial for dialysis patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

29.

Vitamin D in Foot and Ankle Fracture Healing: A Literature Review and Research Design.

Author: BernhardAndrew, MatukJorge

Vitamin D
Fracture healing

Vitamin D is important for calcium levels and bone health. While research has focused on vitamin D's role in preventing fractures, especially in women and people with osteoporosis, there is limited research on its effect on healing broken bones. Most studies include calcium in the treatment, making it difficult to isolate the effect of vitamin D. Animal studies have also been inconclusive. While some case reports are promising, further research is needed to confirm the benefits of vitamin D for fracture healing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

A Randomized, Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency.

Author: SchleckMarie-Louise, SouberbielleJean-Claude, JandrainBernard, Da SilvaStéphanie, De NietSophie, VanderbistFrancis, ScheenAndré, CavalierEtienne

VTD status

Many people worldwide have low vitamin D levels. This study investigated the effectiveness of different doses of vitamin D in raising vitamin D levels in adults. The study found that higher doses of vitamin D led to faster and greater increases in vitamin D levels, with no significant side effects. The study recommends a single large dose (200,000 IU) followed by a monthly dose of 100,000 IU as the best way to quickly and safely increase vitamin D levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Cholecalciferol Additively Reduces Serum Parathyroid Hormone and Increases Vitamin D and Cathelicidin Levels in Paricalcitol-Treated Secondary Hyperparathyroid Hemodialysis Patients.

Author: ZhengJing-Quan, HouYi-Chou, ZhengCai-Mei, LuChien-Lin, LiuWen-Chih, WuChia-Chao, HuangMing-Te, LinYuh-Feng, LuKuo-Cheng

SHPT treatment

People on dialysis often have a problem called secondary hyperparathyroidism (SHPT), where their parathyroid glands become overactive. Active vitamin D is used to treat this, but adding regular vitamin D supplements may further improve parathyroid gland function and reduce the risk of high calcium and phosphate levels. This study is investigating the potential benefits of combining these two forms of vitamin D treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in primary care.

Author: HinH, TomsonJ, NewmanC, KurienR, LayM, CoxJ, SayerJ, HillM, EmbersonJ, ArmitageJ, ClarkeR

Vitamin D treatment

This study found that taking 4,000 IU of vitamin D3 daily for a year was needed to achieve blood levels of vitamin D associated with the lowest risk of disease. Further research is needed to determine if this dose can help prevent fractures.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults.

Author: VaesAnouk M M, TielandMichael, de RegtMargot F, WittwerJonas, van LoonLuc J C, de GrootLisette C P G M

Vitamin D treatment

Older adults are often recommended to take vitamin D supplements to maintain healthy levels of vitamin D in their blood. This study compared different doses of calcifediol and vitamin D3 supplements to determine the amount needed to achieve a target blood vitamin D level between 75 and 100 nmol/L.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis.

Author: UenishiK, TokiwaM, KatoS, ShirakiM

Vitamin D treatment

This study investigated how different vitamin D treatments affected calcium absorption in the intestines. It found that while regular vitamin D3 increased vitamin D levels in the blood, a medication called eldecalcitol reduced these levels. Both treatments increased calcium absorption, which may be due to direct activation of vitamin D receptors in the intestines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Comparison Of Different Formulations Of Vitamin D.

Author: Fahan RashidHafiz Muhammad, SyedUneeba, AhmadZaheer, ChauhdaryKbaa Khalil, MusharrafUsman, KumarSuresh

VDD treatment

Vitamin D deficiency (VDD) is a common problem worldwide, including Pakistan. Vitamin D supplements are used to prevent and treat VDD, but the amount of vitamin D that different forms of supplements raise in the blood is not well-studied. This research aims to determine how much vitamin D levels increase after taking different forms of vitamin D supplements, which can help determine the best dose and delivery method.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D₃ Supplementation.

Author: De NietSophie, CoffinerMonte, Da SilvaStéphanie, JandrainBernard, SouberbielleJean-Claude, CavalierEtienne

Monthly administration
Vitamin D deficiency treatment

This study compared taking vitamin D3 daily versus monthly to achieve the same total dose. Taking a large dose of vitamin D3 monthly resulted in faster improvement in blood vitamin D levels than taking a smaller daily dose, reaching the target level of 20 ng/mL within one day compared to two weeks for the daily dose.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences.

Author: Dalle CarbonareLuca, ValentiMaria Teresa, Del FornoFrancesco, PiacentiniGiorgio, PietrobelliAngelo

Hypovitaminosis treatment
Vitamin D3

Vitamin D plays a role in bone health and other conditions, including digestive problems, heart disease, cancer, and autoimmune diseases. This study compared the effects of taking vitamin D daily versus monthly to achieve the same total dose in people with low vitamin D levels. Both approaches were found to be effective in raising vitamin D levels, and taking a large monthly dose led to faster improvements compared to a daily dose. After 18 months of monthly treatment, vitamin D levels were normal, calcium levels increased, and bone turnover decreased. Interestingly, people with larger waists had lower vitamin D levels at the start of the study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial.

Author: RuggieroCarmelinda, BaroniMarta, BiniVittorio, BrozzettiAnnalisa, ParrettiLuca, ZengariniElisa, LapennaMaria, AntinolfiPierluigi, FalorniAlberto, MecocciPatrizia, BoccardiVirginia

Improved vitamin D levels

This study looked at the effects of vitamin D supplements (D3 or 25D3) in very elderly individuals. Both types of vitamin D increased levels of 25(OH)D and 1-25(OH)D in the blood, with 25D3 showing a faster improvement. While both supplements also lowered levels of parathyroid hormone (iPTH) and C-reactive protein (CRP), those taking many medications or with weak handgrip strength were less likely to see their vitamin D levels improve.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

What factors modify the effect of monthly bolus dose vitamin D supplementation on 25-hydroxyvitamin D concentrations?

Author: WuZhenqiang, CamargoCarlos A, ReidIan R, BerosAngela, SluyterJohn D, WaayerDebbie, LawesCarlene M M, ToopLes, KhawKay-Tee, ScraggRobert

Improved vitamin D levels

This study found that the effectiveness of vitamin D supplements in raising blood levels of vitamin D (25(OH)D) was influenced by several factors. People with lower baseline vitamin D levels, higher body mass index (BMI), and less sun exposure saw less of an increase in their vitamin D levels after taking supplements. Women, older adults, and those who frequently drank alcohol, were taking vitamin D medication, or had asthma/COPD experienced a greater increase in vitamin D levels. Ethnicity, tobacco smoking, and vigorous physical activity did not seem to affect the response to vitamin D supplements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents

Author: NalbantoğluÖzlem, AcarSezer, ArslanGülçin, KöprülüÖzge, ÖzkanBehzat

Effective vitamin D treatment

Buccal spray and oral drops of vitamin D3 were equally effective in raising vitamin D concentrations in children with vitamin D deficiency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen.

Author: RothenJean-Pierre, RutishauserJonas, WalterPhilipp N, HersbergerKurt E, ArnetIsabelle

Vitamin D deficiency treatment

This study compared different ways to take vitamin D supplements to treat vitamin D deficiency. It found that a personalized, higher initial dose (loading regimen) taken weekly was more effective in raising vitamin D levels to a healthy range compared to taking a lower dose monthly. The loading regimen resulted in all participants reaching sufficient vitamin D levels and a higher percentage reaching higher levels (greater than 75 nmol/l). The study also found no side effects and that patients preferred taking capsules over a liquid form.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Critical Appraisal of Large Vitamin D Randomized Controlled Trials.

Author: PilzStefan, TrummerChristian, Theiler-SchwetzVerena, GrüblerMartin R, VerheyenNicolas D, OdlerBalazs, KarrasSpyridon N, ZittermannArmin, MärzWinfried

Vitamin D treatment
Safety concerns

While vitamin D is important for bone health, research on its benefits for other conditions, like cancer, heart disease, and overall survival, has been mixed. Many recent studies on vitamin D have included people who weren't deficient, and some even gave moderate doses of vitamin D to the control groups. These studies haven't found strong evidence for these benefits, but some smaller studies and analyses suggest possible benefits, like reduced cancer death and fewer infections. Large doses of vitamin D haven't been shown to be unsafe in most people, except for those who are very sick or take very high doses infrequently. Future research should focus on people with vitamin D deficiency or who are likely to benefit from vitamin D and use more personalized approaches to treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

46.

Time out: should vitamin D dosing be based on patient's body mass index (BMI): a prospective controlled study.

Author: Sadat-AliMir, AlTabashKhalid W, Al-TurkiHaifa A, AlMousaSulaiman A, AlSayedHasan N

Vitamin D deficiency treatment

This study found that the recommended daily dose of vitamin D (2000 IU) may not be enough for overweight and obese people. After initially increasing vitamin D levels, those who continued to take the standard dose (2000 IU) had lower vitamin D levels after 6 months compared to those who took a higher dose based on their body mass index (BMI). This suggests that vitamin D dosage should be adjusted for BMI to maintain healthy vitamin D levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial.

Author: JenssenMarita, FurbergAnne-Sofie, JordeRolf, WilsgaardTom, DanielsenKjersti

Psoriasis severity

Vitamin D supplementation did not affect psoriasis severity in adults with active plaque psoriasis. There was no significant difference in change in PASI score between the vitamin D and placebo groups.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Daily vs. monthly oral vitamin D<sub>3</sub> for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial.

Author: GoraAnupriya, SinghPreeti, DebnathEkta, MalhotraRajeev Kumar, SethAnju

Improves bone health
Increases vitamin D levels
Mild hypercalcemia

Both daily and monthly oral vitamin D supplementation were effective in treating symptomatic vitamin D deficiency in infants. In a randomized study of 90 infants, both regimens led to significant improvements in calcium and phosphorus levels and a decrease in alkaline phosphatase and parathyroid hormone levels.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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