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Phenothiazine-type antipsychotics elicit cutaneous analgesia in rats.

Author: ChenYu-Wen, ChienChih-Chiang, ChuChin-Chen, ChuKoung-Shing, KaoCheng-Hsing, ShiehJa-Ping, WangJhi-Joung

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Phenothiazine-type antipsychotics, like chlorpromazine, are known to block sodium channels in the nervous system. This study investigates whether these drugs have analgesic effects on the skin.
Paper Details　
Original Abstract of the Article :
Local anesthetics exert their anesthetic and analgesic effects by blocking the sodium channels in the nervous system. Phenothiazine-type antipsychotics also block sodium channels, but the local anesthetic characteristics of these drugs have not been evaluated. The aim of this study was to evaluate t...See full text at original site
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引用元：
https://doi.org/10.1016/S1875-4597(10)60002-1

データ提供：米国国立医学図書館（NLM）

A Surprising Discovery: Phenothiazines and Pain Relief

[Local anesthetics], well-known for their ability to numb pain, work by blocking [sodium channels] in the nervous system. [Phenothiazines], a class of [antipsychotics], also interact with [sodium channels]. However, their potential for pain relief has not been thoroughly investigated. This study explores the analgesic effects of [phenothiazines] on [cutaneous pain] in rats.

The researchers found that [phenothiazines] exhibited [cutaneous analgesic] properties. This is like a camel encountering a hidden spring in the desert, leading to unexpected relief from thirst. They concluded that [phenothiazines] may have a [dual mechanism of action], acting not only as [antipsychotics] but also as [analgesics].

A New Perspective on Phenothiazines

The study reveals a previously unexplored aspect of [phenothiazines], suggesting they may have analgesic properties in addition to their antipsychotic effects. This finding opens up new possibilities for understanding and potentially utilizing these drugs.

Beyond the Mind: Exploring the Analgesic Potential of Phenothiazines

This research challenges our understanding of [phenothiazines], suggesting they may hold untapped potential for pain management. This discovery underscores the importance of continued exploration in [pharmacology] to uncover hidden therapeutic properties of existing drugs.

Dr.Camel's Conclusion

This study reminds us that the desert of [pharmacology] is full of hidden springs and unexpected discoveries. By exploring the diverse properties of existing medications, we can potentially uncover new avenues for treating pain and improving human well-being.

Date :
  1. Date Completed 2010-07-30
  2. Date Revised 2010-05-03
Further Info :

Pubmed ID

20434106

DOI: Digital Object Identifier

10.1016/S1875-4597(10)60002-1

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English

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