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The L6 muscle cell line as a tool to evaluate parenteral products for irritation.

Author: LaskaD A, MorrisR M, RebouletJ T, WilliamsP D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The L6 rat skeletal muscle cell line proved useful in assessing the local irritancy of eight commercially available parenteral pharmaceuticals. Cellular damage, measured by creatine phosphokinase (CK) depletion, correlated well with known clinical irritation and side effects. This demonstrates the versatility of the model for testing various parenteral formulations.
Paper Details　
Original Abstract of the Article :
A rat skeletal muscle cell line (L6) was evaluated for its utility in assessing cellular damage caused by parenteral administration of eight commercially available pharmaceuticals. The physical forms of the eight pharmaceuticals were diverse, including aqueous and non-aqueous suspensions and solutio...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2051260

データ提供：米国国立医学図書館（NLM）

The L6 Muscle Cell Line: A New Tool for Evaluating Parenteral Products

The development of safe and effective parenteral products, those administered directly into the bloodstream, is a complex journey through the vast desert of drug development. This study introduces the L6 muscle cell line as a valuable tool for assessing the potential irritation of parenteral products. The authors tested the cell line's ability to detect irritation caused by eight commercially available pharmaceuticals, a process akin to carefully examining the terrain for potential hazards.

Navigating the Desert of Parenteral Safety

The L6 muscle cell line proved to be a reliable guide in this scientific expedition, accurately reflecting the potential for irritation observed in clinical use. This model, like a well-trained camel, can navigate the intricate terrain of parenteral drug development, helping researchers identify potentially harmful products and ensure the safety of patients.

Safeguarding Patient Health

The study demonstrates the importance of rigorous testing in drug development. The L6 cell line provides a valuable tool for assessing the potential for irritation, helping us avoid unnecessary risks to patient health. This model, like a watchful sentinel guarding a desert oasis, provides a vital safeguard for patient safety.

Dr. Camel's Conclusion

This study highlights the importance of using innovative tools to assess the safety of parenteral products. The L6 muscle cell line offers a valuable method for detecting potential irritation, a crucial step in ensuring the well-being of patients. By employing such tools, we can navigate the vast desert of drug development with greater confidence and ensure the safety of our patients.
Date :
  1. Date Completed 1991-07-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2051260

DOI: Digital Object Identifier

2051260

SNS
PICO Info
in preparation
Languages

English

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