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Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.

Author: BinghamClifton O, BradleyJohn D, CleggDaniel O, DunlopDorothy D, FincoMartha F, FurstDaniel E, HarrisCrystal L, JacksonChristopher G, LaneNancy E, LisseJeffrey, MoskowitzRoland W, OddisChester V, RedaDomenic J, SawitzkeAllen D, ShiHelen, SilverDavid, SingerNora G, WilliamsH James, WolfeFred

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Over two years, no treatment (glucosamine, chondroitin sulfate, combined glucosamine/chondroitin, celecoxib, or placebo) achieved a clinically important difference in pain or function compared to placebo in patients with knee osteoarthritis. While glucosamine and celecoxib showed trends towards benefit, these were not statistically significant. Adverse reactions were similar among treatment groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Knee osteoarthritis (OA) is a major cause of pain and functional limitation in older adults, yet longer-term studies of medical treatment of OA are limited. OBJECTIVE: To evaluate the efficacy and safety of glucosamine and chondroitin sulphate (CS), alone or in combination, as well as c...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20525840

データ提供：米国国立医学図書館（NLM）

Glucosamine, Chondroitin, and Celecoxib: A Long-Term Look at Osteoarthritis Treatment

Osteoarthritis (OA), a common joint disorder, affects millions of people worldwide. This study investigates the long-term efficacy and safety of glucosamine, chondroitin sulfate, their combination, celecoxib, and placebo in treating knee OA. The authors conducted a 2-year, double-blind, placebo-controlled trial to evaluate the effectiveness and safety of these treatments.

A Long-Term Desert Trek: Evaluating the Effectiveness of OA Treatments

The study found no clinically significant difference in pain or function between any treatment group and placebo over 2 years. However, it observed beneficial trends with glucosamine and celecoxib, suggesting that these agents may offer potential benefits in the long term. The authors also highlight the favorable safety profile of all treatments.

A Journey Through Time: Finding the Right Path for OA Management

This research provides valuable insights into the long-term effectiveness and safety of different treatment options for knee OA. It reminds us that the journey of OA management is often long and requires careful consideration of individual patient needs, preferences, and potential risks. Like navigating a vast and challenging desert, it's important to stay informed, seek expert guidance, and adapt our approach based on the evolving landscape of OA treatment.

Dr. Camel's Conclusion

This study underscores the complexity of osteoarthritis treatment and the importance of long-term evaluations. The findings suggest that while no single treatment stands out as a clear winner, glucosamine and celecoxib may offer potential benefits in the long run. The study also emphasizes the need for a personalized approach to OA management, taking into account individual patient factors and the evolving nature of this chronic condition.

Date :
  1. Date Completed 2010-08-13
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

20525840

DOI: Digital Object Identifier

NIHMS267850

Related Literature

Article Analysis
・Effective treatment of osteoarthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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