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The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men.

Author: BasariaShehzad, BhasinShalender, KaplanBeth, KnappPhilip E, LaValleyMichael P, LakshmanKishore M, MazerNorman A, SinghAtam B, TravisonThomas G

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.
Paper Details　
Original Abstract of the Article :
BACKGROUND: During testosterone (T) therapy, T is partly converted to 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown. OBJECTIVE: We evaluated age and dose-related differences in E2 a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/

データ提供：米国国立医学図書館（NLM）

Testosterone: A Tale of Two Ages

This study in the field of endocrinology dives into the complex interplay between testosterone (T), age, and the conversion of T to estradiol (E2) and dihydrotestosterone (DHT). Researchers aimed to explore the impact of age and varying doses of testosterone enanthate on E2 and DHT levels in both young and older men. This study helps us to understand the nuanced changes in hormone levels as we age.

Hormones: A Balancing Act

The study found a dose-dependent increase in both total and free E2 levels in both young and older men during testosterone administration. However, older men exhibited higher total and free E2 levels, as well as higher E2:T ratios. This suggests that the conversion of T to E2 is more pronounced in older men. While DHT levels showed a dose-dependent increase in both age groups, there was no significant difference in DHT levels between young and older men.

Hormonal Health: A Lifetime Journey

These findings highlight the importance of understanding how hormone levels change with age and how those changes affect our health. It emphasizes the need to approach hormone replacement therapy with caution and tailor treatment strategies based on individual needs and conditions.

Dr.Camel's Conclusion

This study sheds light on the intricate dynamics of testosterone conversion and its interplay with age. It reveals that the conversion of testosterone to estradiol is more pronounced in older men, suggesting a need for age-specific considerations in testosterone therapy. This research contributes to a deeper understanding of hormonal changes associated with aging and underscores the importance of personalized approaches to managing hormonal health across the lifespan.

Date :
  1. Date Completed 2010-08-24
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

20534765

DOI: Digital Object Identifier

PMC2913038

SNS
PICO Info
in preparation
Languages

English

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