Effects of testosterone buccal: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Testosterone is a male hormone that declines with age. Several studies have investigated the effects of testosterone replacement therapy in various populations. 20 found that testosterone gel treatment in men aged 65 and older with symptoms of low testosterone improved sexual function, mood, and depressive symptoms. 10 found that testosterone gel applied as needed improved sexual desire and function in premenopausal women. 8 found no significant effects of aromatase inhibition on cognition in healthy, estrogen-treated postmenopausal women who received testosterone gel. 4 found minimal effects of testosterone on mood and behavior in healthy men, but noted that higher doses (around 500 mg per week of testosterone cypionate) could lead to adverse psychological effects in a minority of men. 19 found no significant changes in cognitive function in hysterectomized women with low testosterone levels after receiving various doses of testosterone enanthate for 24 weeks. 16 explored the effects of adding testosterone to estrogen therapy in oophorectomized women and found no significant effects on memory function. 14 examined the timetable of effects of testosterone administration to hypogonadal men and found improvements in sexual thoughts, interest, desire, and erections as well as a decrease in depression scores. 25 studied the effects of testosterone administration on brain activity in energy-deficient men and found that testosterone may have different effects in this population compared to men with adequate energy levels. 18 compared strength training and testosterone treatment in older men and found that testosterone treatment may be associated with increased inflammation. 1 found that supraphysiological levels of testosterone in healthy men increased sexual awareness and arousability, but not overt sexual behavior. 22 concluded that testosterone replacement therapy is associated with improvements in quality of life, libido, depression, and erectile function in hypogonadal men, but further research is needed to assess long-term risks. 13 found improvements in sexual function and mood in hypogonadal men who received either testosterone enanthate or testosterone undecanoate. 15 studied the effects of testosterone dose and age on testosterone metabolism and found that the rate of aromatization (conversion of testosterone to estradiol) was higher in older men. 7 found that testosterone undecanoate led to minor mood changes but did not increase aggressive behavior or sexual behavior in healthy young men. 11 explored the acute effects of testosterone on genital arousal in postmenopausal women and found that testosterone led to a significant increase in vaginal pulse amplitude 4.5 hours after administration. 9 provided an overview of the effects of testosterone treatment on sarcopenia (age-related muscle loss). 23 found that ingestion of protein or glucose resulted in acute decreases in testosterone and luteinizing hormone in adolescent males. 3 found no significant changes in prostate volume or PSA levels in healthy young men after receiving testosterone injections. 26 found suggestive evidence that estradiol, in the absence of testosterone, may increase fat mass in men. 27 discussed the rationale and design of a study to assess the long-term effects of testosterone treatment on cardiovascular outcomes in men with hypogonadism. 5 found that androstenedione supplementation did not increase testosterone levels or enhance muscle adaptations to resistance training in young men. 24 found that testosterone administration affected the physiological response to social and somatic stressors in men. 17 studied the pharmacokinetics of sublingual testosterone in premenopausal women and found that it increased testosterone levels. 2 found that testosterone undecanoate increased sexual interest in men with Klinefelter’s syndrome. 6 investigated the dose-response relationships of testosterone in healthy young men and found that higher testosterone doses led to greater increases in muscle mass and strength. 21 suggested that estrogens may have an independent effect on the prostate. 12 found that testosterone undecanoate was effective for androgen therapy in female to male transsexual subjects. 28 found that estradiol treatment in men undergoing androgen deprivation therapy increased bone density and strength and reduced bone remodeling. These findings demonstrate the potential benefits and risks of testosterone replacement therapy, emphasizing the need for individualized care and ongoing research.

Benefits and Risks

Benefit Summary

Testosterone replacement therapy may offer several potential benefits, including improved sexual function, mood, and depressive symptoms. It may also lead to increased muscle strength and mass. 20 、 10 、 14 、 9 、 6

Risk Summary

Testosterone replacement therapy carries potential risks, including increased red blood cell count, prostate abnormalities, cardiovascular risk, aggression, fat gain, bone health issues, and altered stress responses. 20 、 22 、 26 、 27 、 5 、 24 、 3 、 12 、 28 、 7 、 15 It's important to discuss these potential risks with a healthcare provider before starting testosterone replacement therapy.

Comparing Research

Similarities

Multiple studies indicate that testosterone replacement therapy can improve sexual function, mood, and depressive symptoms. Some studies also suggest potential benefits for muscle strength and mass. 20 、 10 、 14 、 9 、 6

Differences

The effects of testosterone replacement therapy can vary depending on the study participants, administration method, dose, and duration of treatment. Some studies have shown potential effects on cognitive function, aggression, and stress responses, but not all studies have consistently found the same results. 8 、 19 、 16 、 25 、 5 、 24 、 7 、 26 、 27 、 15 、 28

Consistency and Contradictions in Results

While some studies demonstrate the potential benefits of testosterone replacement therapy, not all studies have found consistent results. Additionally, some studies suggest potential risks associated with testosterone replacement therapy. Further research is needed to clarify the effects and risks. 20 、 10 、 8 、 4 、 19 、 16 、 14 、 25 、 18 、 1 、 22 、 13 、 15 、 7 、 11 、 9 、 23 、 3 、 26 、 27 、 5 、 24 、 17 、 2 、 6 、 21 、 12 、 28

Important Considerations for Real-World Application

Testosterone replacement therapy should be used under the guidance of a healthcare professional. Self-treating can be dangerous. It's important to weigh the potential benefits and risks of testosterone replacement therapy before starting treatment. Individualized care is crucial for determining appropriate treatment strategies and monitoring potential side effects.

Limitations of Current Research

The research on testosterone replacement therapy is still incomplete. More long-term studies are needed to understand the long-term effects of testosterone replacement therapy. Additionally, it’s important to recognize that the effects of testosterone replacement therapy can vary widely from person to person. Further research is needed to identify factors that contribute to individual variation in response to testosterone replacement therapy.

Future Research Directions

More research is needed to investigate the long-term effects of testosterone replacement therapy. It is also crucial to develop individualized approaches to assessing the benefits and risks of testosterone replacement therapy.

Conclusion

Testosterone replacement therapy may offer potential benefits for sexual function, mood, and depressive symptoms. However, it also comes with potential risks, including increased red blood cell count, prostate abnormalities, cardiovascular risk, aggression, fat gain, bone health issues, and altered stress responses. Testosterone replacement therapy should only be used under the guidance of a healthcare professional.

Literature analysis of 28 papers
Positive Content
22
Neutral Content
2
Negative Content
4
Article Type
26
2
1
1
28
1.

The effects of exogenous testosterone on sexuality and mood of normal men.

Author: AndersonR A, BancroftJ, WuF C

Increased arousability
No aggression changes
No mood changes

Supraphysiological levels of testosterone increased sexual awareness and arousability in 31 normal men, but did not significantly affect overt sexual behavior.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The behavioural effects of testosterone undecanoate in adult men with Klinefelter's syndrome: a controlled study.

Author: WuF C, BancroftJ, DavidsonD W, NicolK

Increased sexual interest

Testosterone undecanoate, a form of testosterone, was found to modestly increase sexual interest in men with low normal testosterone levels, but had no significant effect on mood, energy, or erectile responsiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effect of exogenous testosterone on prostate volume, serum and semen prostate specific antigen levels in healthy young men.

Author: CooperC S, PerryP J, SparksA E, MacIndoeJ H, YatesW R, WilliamsR D

Exogenous testosterone injections in healthy young men do not significantly increase prostate volume or serum PSA levels, despite significant increases in serum testosterone levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Psychosexual effects of three doses of testosterone cycling in normal men.

Author: YatesW R, PerryP J, MacIndoeJ, HolmanT, EllingrodV

Adverse psychological effects

Testosterone doses up to five times physiologic replacement dose had minimal risk of adverse psychosexual effects in most men, but higher doses may cause psychological problems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial.

Author: KingD S, SharpR L, VukovichM D, BrownG A, ReifenrathT A, UhlN L, ParsonsK A

Increased estradiol
Increased estrone
Reduced HDL cholesterol

Androstenedione supplementation does not increase serum testosterone concentrations or enhance skeletal muscle adaptations to resistance training in normotestosterogenic young men. It may result in adverse health consequences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Testosterone dose-response relationships in healthy young men.

Author: BhasinS, WoodhouseL, CasaburiR, SinghA B, BhasinD, BermanN, ChenX, YarasheskiK E, MaglianoL, DzekovC, DzekovJ, BrossR, PhillipsJ, Sinha-HikimI, ShenR, StorerT W

Improved power
Increased muscle mass
Increased strength
Decreased HDL cholesterol
Increased fat mass

This study found that testosterone effects are dose-dependent and that changes in fat-free mass, muscle size, strength, and power are positively correlated with testosterone concentrations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study.

Author: O'ConnorDaryl B, ArcherJohn, WuFrederick C W

Male contraception
Anger-hostility increase
Fatigue-inertia reduction
Mood changes

Testosterone undecanoate (TU), a long-acting testosterone preparation, was studied for its effects on mood and behavior in healthy men.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Testosterone aromatization and cognition in women: a randomized, placebo-controlled trial.

Author: ShahSonal, BellRobin J, SavageGreg, GoldstatRebecca, PapaliaMary-Anne, KulkarniJayashri, DonathSusan, DavisSusan R

Improved concentration
Improved memory

In postmenopausal women treated with testosterone, aromatase inhibition did not affect cognition. However, the study may have lacked sufficient power to detect subtle changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

[Testosterone treatment of sarcopenia].

Author: StárkaL

Fat mass decrease
Muscle mass increase
Muscle strength increase
Increased hematocrit
Prostate events

Testosterone increases muscle mass and decreases fat mass in men. It also improves muscle strength. The most common side effects of testosterone treatment include increased hematocrit and risk of prostate problems.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Czech

10.

Transdermal testosterone gel prn application for hypoactive sexual desire disorder in premenopausal women: a controlled pilot study of the effects on the arizona sexual experiences scale for females and sexual function questionnaire.

Author: ChudakovBella, Ben ZionItzhak Z, BelmakerR H

Improve sexual desire
Improve sexual function
Side effects of testosterone

Sublingual testosterone can improve sexual function and desire in postmenopausal women, but its effects are temporary, peaking after 15 minutes and declining to baseline within 90 minutes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Genital and subjective measurement of the time course effects of an acute dose of testosterone vs. placebo in postmenopausal women.

Author: Heard-DavisonAmy, HeimanJulia R, KuffelStephanie

Improves genital arousal

An acute dose of methyltestosterone significantly increased vaginal pulse amplitude at 4.5 hours post-dose, but there were no differences in self-reported sexual arousal scores.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Effects of testosterone undecanoate administered alone or in combination with letrozole or dutasteride in female to male transsexuals.

Author: MeriggiolaMaria Cristina, ArmillottaFrancesca, CostantinoAntonietta, AltieriPaola, SaadFarid, KalhornThomas, PerroneAnna Myriam, GhiTullio, PelusiCarlotta, PelusiGiuseppe

Androgen therapy

Testosterone undecanoate (TU) is a potential androgen therapy for female-to-male (FtM) transsexual subjects. However, long-term physiologic effects and the significance of testosterone and its metabolites on specific outcome parameters are currently unknown.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Comparison of long-acting testosterone undecanoate formulation versus testosterone enanthate on sexual function and mood in hypogonadal men.

Author: JockenhövelF, MinnemannT, SchubertM, FreudeS, HüblerD, SchumannC, ChristophA, ErnstM

Mood improvement
Sexual function

This study compared the effects of two testosterone treatment modalities on sexual function and mood in 40 men. Men were randomly assigned to receive either parenteral testosterone enanthate (TE) or long-acting parenteral testosterone undecanoate (TU) for 30 weeks. Subsequently, 20 men who had received TU and 16 men who had received TE continued with TU for an additional 65 weeks to assess the long-term effects of TU.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Timetable of effects of testosterone administration to hypogonadal men on variables of sex and mood.

Author: JockenhövelFriedrich, MinnemannTimo, SchubertMarkus, FreudeSusanne, HüblerDoris, SchumannChristina, ChristophArnd, GoorenLouis, ErnstMichael

Improved fatigue
Improved mood
Improved self-confidence
Improved sexual function

Testosterone treatment in hypogonadal men showed varying timetables for different effects. Sexual thoughts/fantasies, sexual interest, and depression scores improved quickly, while erections, ejaculations, and good mood took longer to reach a plateau.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men.

Author: LakshmanKishore M, KaplanBeth, TravisonThomas G, BasariaShehzad, KnappPhilip E, SinghAtam B, LaValleyMichael P, MazerNorman A, BhasinShalender

During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. The rate of whole body aromatization is higher in older men, partly related to their higher percentage fat mass, SHBG, and testosterone levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

16.

Effects of testosterone and estrogen replacement on memory function.

Author: MöllerMarika C, BartfaiAniko B, RådestadAngelique Flöter

Improved memory

This study investigated the effects of adding testosterone to estrogen therapy in women who have had their ovaries removed. The study found that adding testosterone to estrogen therapy did not improve memory function in these women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Pharmacokinetics of three doses of sublingual testosterone in healthy premenopausal women.

Author: van RooijKim, BloemersJos, de LeedeLeo, GoldsteinIrwin, LentjesEef, KoppeschaarHans, OlivierBerend, TuitenAdriaan

Cognitive behavior improvement
Sexual behavior improvement
Social behavior improvement

Sublingual testosterone is a treatment for low testosterone levels that is often used in studies of social, cognitive, and sexual behavior. The study found that an increase in the ratio of free to total testosterone may be responsible for the behavioral effects of sublingual testosterone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Strength training and testosterone treatment have opposing effects on migration inhibitor factor levels in ageing men.

Author: GlintborgD, ChristensenL L, KvorningT, LarsenR, BrixenK, HougaardD M, RichelsenB, BruunJ M, AndersenM

Fat mass reduction
Lean body mass increase
Increased inflammatory activity

A study of 54 men with low testosterone levels found that strength training plus placebo was associated with decreased inflammatory activity. Testosterone treatment was associated with increased inflammatory activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial.

Author: HuangG, WhartonW, TravisonT G, HoM H, GleasonC, AsthanaS, BhasinS, BasariaS

No cognitive improvement

Testosterone administration over a wide range of doses for 24 weeks in women with low testosterone levels was not associated with improvements or worsening of cognitive function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

20.

Effects of Testosterone Treatment in Older Men.

Author: SnyderPeter J, BhasinShalender, CunninghamGlenn R, MatsumotoAlvin M, Stephens-ShieldsAlisa J, CauleyJane A, GillThomas M, Barrett-ConnorElizabeth, SwerdloffRonald S, WangChristina, EnsrudKristine E, LewisCora E, FarrarJohn T, CellaDavid, RosenRaymond C, PahorMarco, CrandallJill P, MolitchMark E, CifelliDenise, DougarDarlene, FluhartyLaura, ResnickSusan M, StorerThomas W, AntonStephen, BasariaShehzad, DiemSusan J, HouXiaoling, MohlerEmile R, ParsonsJ Kellogg, WengerNanette K, ZeldowBret, LandisJ Richard, EllenbergSusan S,

Depressive symptoms
Mood improvement
Sexual function
Hypoandrogenism

In symptomatic men aged 65 or older with moderately low testosterone levels, raising testosterone levels for 1 year to the mid-normal range had a moderate benefit for sexual function and some benefit for mood and depressive symptoms. There was no benefit for vitality or walking distance. The number of participants was too small to draw conclusions about the risks of testosterone treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in Older Men.

Author: DiasJenny Pena, MelvinDenise, ShardellMichelle, FerrucciLuigi, ChiaChee W, GharibMohsen, EganJosephine M, BasariaShehzad

Prostate health monitoring

This review highlights the importance of monitoring prostate health during testosterone (T) replacement therapy for older men with age-related low T. It discusses the independent effects of estrogens and the potential role of estradiol, produced through T aromatization, in T-related prostate effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis.

Author: ElliottJesse, KellyShannon E, MillarAdam C, PetersonJoan, ChenLi, JohnstonAmy, KotbAhmed, SkidmoreBecky, BaiZemin, MamdaniMuhammad, WellsGeorge A

Improved erectile function
Improved libido
Improved quality of life
Reduced depression
Withdrawals due to adverse events

Testosterone replacement therapy (TRT) has a class effect of improving quality of life, depression, erectile function, and libido in hypogonadal men. However, no individual testosterone product consistently demonstrated superiority in improving these outcomes. There was no statistically significant increase in the risk of adverse events, but longer-term, high-quality trials are needed to fully assess the risks of harm.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males.

Author: SchwartzAlexander, HunschedeSascha, LacombeRussel John Scott, ChatterjeeDiptendu, Sánchez-HernándezDiana, KubantRuslan, BazinetRichard Paul, HamiltonJill K, AndersonGerald Harvey

Decreased testosterone

Protein or glucose ingestion resulted in acute decreases in plasma testosterone and LH in adolescent males.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

The effects of testosterone on the physiological response to social and somatic stressors.

Author: KutlikovaHana H, DurdiakováJaroslava Babková, WagnerBernhard, VlčekMiroslav, EiseneggerChristoph, LammClaus, RiečanskýIgor

Social anxiety reduction
Stress modulation

Testosterone's effects on stress response have been inconsistent. This study found that testosterone increased blood pressure during non-social stress, but decreased it during socially-evaluated stress. This suggests that testosterone's effects on stress response are context-dependent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Effects of testosterone administration on fMRI responses to executive function, aggressive behavior, and emotion processing tasks during severe exercise- and diet-induced energy deficit.

Author: CarmichaelOwen T, PillaiSreekrishna R, MurrayKori, ShankapalPreetham, CaldwellJohn, VartanianOshin, BerrymanClaire E, KarlJ P, HarrisMelissa, RoodJennifer C, PasiakosStefan M, LiebermanHarris R

brain function
cognitive function
testosterone administration

Testosterone administration is associated with improved brain and cognitive function, as well as mood, in energy-balanced males, although such relationships are controversial. However, the effects of testosterone administration on the brains of energy-deficient males have not been investigated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

26.

Effects of estradiol on fat in men undergoing androgen deprivation therapy: a randomized trial.

Author: RussellNicholas, HoermannRudolf, CheungAda S, ZajacJeffrey D, HandelsmanDavid J, GrossmannMathis

Fat mass increase

This study provides suggestive evidence that estradiol (E2), acting in the absence of testosterone, may increase total and regional fat mass in men. While further research is needed, this finding challenges the prevailing understanding of E2's role in fat mass regulation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Effects of long-term testosterone treatment on cardiovascular outcomes in men with hypogonadism: Rationale and design of the TRAVERSE study.

Author: BhasinShalender, LincoffA Michael, BasariaShehzad, BauerDouglas C, BodenWilliam E, CunninghamGlenn R, DaveyDeborah, DubcencoElena, FukumotoSandra, GarciaMichelle, GrangerChristopher B, KalahastiVidyasagar, KheraMohit, MillerMichael G, MitchellLisa M, O'LearyMichael P, PencinaKarol M, SnyderPeter J, ThompsonIan M, TravisonThomas G, WolskiKathy, NissenSteven E,

Improved cardiovascular health
Increased cardiovascular risk

Testosterone may have some benefits for the cardiovascular system, but it may also increase the risk of heart problems. There haven't been any large studies to look at the long-term effects of testosterone treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomized placebo-controlled trial.

Author: RussellNicholas, Ghasem-ZadehAli, HoermannRudolf, CheungAda S, ZajacJeffrey D, Shore-LorentiCat, EbelingPeter R, HandelsmanDavid J, GrossmannMathis

Bone density
Bone strength

Estradiol (E2) treatment increased some measures of bone density and strength in men and reduced bone remodeling, even in the absence of endogenous testosterone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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