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Calcitriol in dialysis patients.

Author: AllenM K, BenjaminD M, DonahayS L, HamburgerR J, LuftF C, MaxwellD R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Calcitriol (1,25(OH)2D3) and vitamin D3 were compared in 22 hemodialysis patients with osteodystrophy. Calcitriol increased calcium levels and decreased alkaline phosphatase levels, while vitamin D3 had no effect. Hypercalcemia occurred in 2 patients on calcitriol, but was easily reversed by dose reduction. Calcitriol is effective and safe for treating osteodystrophy.
Paper Details　
Original Abstract of the Article :
We conducted a 7-month randomized, single, double, single-blind comparison of calcitriol (1,25(OH)2D3) with vitamin D3 in 22 hemodialysis patients to study the effects on the biochemical abnormalities associated with osteodystrophy. Calcitriol was given for 3 mo. All patients had initial prestudy ca...See full text at original site
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引用元：
https://doi.org/10.1002/cpt1978235515

データ提供：米国国立医学図書館（NLM）

Calcitriol: A Potential Oasis in the Desert of Dialysis Osteodystrophy?

This research delves into the management of [osteodystrophy], a bone disorder common in patients undergoing [dialysis]. The study compares the effects of [calcitriol] with [vitamin D3] in [hemodialysis patients] with low [calcium] and [phosphate] levels. The researchers aimed to assess the efficacy of calcitriol in reversing the biochemical abnormalities associated with osteodystrophy.

A Promising Oasis: Calcitriol Shows Effectiveness in Reversing Osteodystrophy

The study's findings demonstrate the effectiveness of calcitriol in reversing the biochemical abnormalities of osteodystrophy in dialysis patients. Calcitriol effectively raised [calcium] levels and reduced [alkaline phosphatase] levels, indicating its potential for improving bone health. This study is a promising step in the treatment of osteodystrophy in dialysis patients.

Navigating the Desert of Dialysis: Understanding the Importance of Vitamin D

The study highlights the crucial role of vitamin D in maintaining bone health, particularly in dialysis patients. It emphasizes the need for careful monitoring and appropriate dosing of calcitriol to effectively manage osteodystrophy and to minimize the risk of [hypercalcemia]. This research is a reminder of the vital role of vitamin D in maintaining overall health, especially in individuals with specific health challenges.

Dr. Camel's Conclusion

This study provides valuable insights into the potential of calcitriol for managing osteodystrophy in dialysis patients. While further research is needed to optimize treatment strategies, the study's findings offer a hopeful glimpse into a potential oasis for improving bone health in this challenging population. This research reminds us that even in the vast desert of chronic kidney disease, there are opportunities to find solutions and improve quality of life.

Date :
  1. Date Completed 1978-06-12
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

205382

DOI: Digital Object Identifier

10.1002/cpt1978235515

Related Literature

Article Analysis
・Effects of calcitriol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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