Effects of calcitriol: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Calcitriol is a type of vitamin D that can be beneficial for various health conditions. One study found that calcitriol is more effective and faster-acting than cholecalciferol in treating hypocalcemia, which is a condition where calcium levels in the blood are too low, after thyroid surgery. 9 Another study showed that calcitriol can improve bone mineral density in elderly patients with osteoporosis. 10 Research also indicates that calcitriol may be effective in treating secondary hyperparathyroidism, a condition that can occur in people with kidney disease. 7

Benefits and Risks

Benefits Summary

Calcitriol, a form of vitamin D, has shown potential benefits in addressing conditions such as hypocalcemia, osteoporosis, and secondary hyperparathyroidism. It plays a crucial role in regulating calcium levels, promoting bone health, and controlling parathyroid hormone levels.

Risks Summary

Calcitriol can potentially lead to side effects such as hypercalcemia (high calcium levels in the blood) and hypercalciuria (high calcium levels in the urine). 2 However, these side effects can usually be managed by adjusting the dosage. 1 In individuals with kidney disease, calcitriol may potentially worsen kidney function. 3 Additionally, calcitriol has been linked to increased oxidative stress and inflammation. 8

Comparison Across Studies

Similarities in Studies

Multiple studies have investigated the effects of calcitriol in various health conditions, demonstrating its potential as a therapeutic agent. These studies consistently highlight calcitriol's role in regulating calcium metabolism, promoting bone health, and controlling parathyroid hormone levels.

Differences in Studies

The effectiveness of calcitriol can vary depending on the specific health condition being treated, the individual's health status, and the dosage and method of administration. For instance, while one study found that calcitriol is more effective than cholecalciferol in treating hypocalcemia after thyroid surgery, 9 another study suggested that intravenous administration of calcitriol may be more beneficial than oral administration in managing secondary hyperparathyroidism. 3 While some studies have shown calcitriol's effectiveness in treating osteoporosis, 2 another study indicated that long-term treatment with calcitriol alone might be insufficient for this condition. 10

Consistency and Contradictions in Findings

While promising benefits of calcitriol have been observed across various studies, it's important to recognize that the effectiveness and safety of calcitriol can vary depending on individual factors. For instance, one study indicated that calcitriol, when used alone, might not be sufficient for long-term management of osteoporosis. 10 However, other studies have shown its effectiveness in controlling parathyroid hormone levels in individuals with kidney disease. 7 Further research is crucial to better understand the nuances of calcitriol's effects and its optimal use in different health contexts.

Practical Implications and Considerations

Calcitriol should only be taken under the guidance of a healthcare professional. Self-treating with calcitriol can be dangerous. If you experience any side effects while taking calcitriol, consult your doctor immediately.

Limitations of Current Research

The existing research on calcitriol is still limited. Further research is needed to thoroughly assess the long-term safety and effectiveness of calcitriol, particularly in different patient populations and for various health conditions. The efficacy and safety of calcitriol can vary significantly between individuals.

Future Research Directions

Future research should focus on evaluating the long-term safety and effectiveness of calcitriol in treating a range of health conditions. Studies are needed to determine optimal dosages, identify potential interactions with other medications, and explore personalized approaches to calcitriol therapy.

Conclusion

Calcitriol, a form of vitamin D, holds potential benefits for managing health conditions like hypocalcemia, osteoporosis, and secondary hyperparathyroidism. However, it is important to remember that calcitriol can have side effects, and its effectiveness can vary between individuals. Always consult with your doctor before taking calcitriol to ensure it is appropriate for your specific health needs.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
9
0
1
1
10
1.

Calcitriol in dialysis patients.

Author: MaxwellD R, BenjaminD M, DonahayS L, AllenM K, HamburgerR J, LuftF C

Reverses osteodystrophy
Hypercalcemia

Calcitriol (1,25(OH)2D3) and vitamin D3 were compared in 22 hemodialysis patients with osteodystrophy. Calcitriol increased calcium levels and decreased alkaline phosphatase levels, while vitamin D3 had no effect. Hypercalcemia occurred in 2 patients on calcitriol, but was easily reversed by dose reduction. Calcitriol is effective and safe for treating osteodystrophy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Metabolic effects of synthetic calcitriol (Rocaltrol) in the treatment of postmenopausal osteoporosis.

Author: GallagherJ C

Osteoporosis treatment
Hypercalcemia
Hypercalciuria

Calcitriol is safe and effective for the long-term treatment of type 1 osteoporosis in women, but requires careful monitoring of calcium levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Pharmacokinetics and efficacy of pulse oral versus intravenous calcitriol in hemodialysis patients.

Author: LevineB S, SongM

Similar efficacy of IV and oral calcitriol
iPTH suppression
Increased serum calcium levels

This study compared the pharmacokinetics and efficacy of pulse oral and intravenous (i.v.) calcitriol in hemodialysis patients with secondary hyperparathyroidism. The study found that intravenous calcitriol achieved higher peak levels but did not have a clinically significant difference in efficacy compared to oral calcitriol. The study suggests that both intravenous and oral calcitriol are effective for suppressing parathyroid hormone (PTH) secretion in hemodialysis patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Dose-response effect of short-term calcitriol treatment on bone and mineral metabolism in normal males.

Author: GramJ, JunkerP, NielsenH K, BollerslevJ

Bone formation increase
Decreased PTH levels
Increased calcium excretion

This study evaluated the effects of short-term treatment with calcitriol on biochemical markers of calcium and bone metabolism in healthy male volunteers. Calcitriol treatment increased osteoblast activity and bone formation without affecting bone resorption.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Low-dose calcitriol prevents the rise in 1,84-iPTH without affecting serum calcium and phosphate in patients with moderate renal failure (prospective placebo-controlled multicentre trial).

Author: RitzE, KüsterS, Schmidt-GaykH, SteinG, ScholzC, KraatzG, HeidlandA

Hyperparathyroidism treatment
Hypercalcemia
Hypercalciuria
Hyperphosphatemia

This study investigates the potential benefits and risks of prophylactic low-dose calcitriol administration in patients with renal secondary hyperparathyroidism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Twice versus thrice weekly administration of intravenous calcitriol in dialysis patients: a randomized prospective trial. Gruppo Italiano di Studio dell'Osteodistrofia Renale.

Author: GallieniM, BrancaccioD, AntonucciF, BellinghieriG, CarpaniP, CozzolinoM, D'AgostinoF, Del MastroG, MallamaceA, MemoliB

Control PTH

This study investigated the effects of intravenous (i.v.) calcitriol administered two or three times weekly in patients with moderate to severe secondary hyperparathyroidism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial.

Author: ItoH, OgataH, YamamotoM, TakahashiK, ShishidoK, TakahashiJ, TaguchiS, KinugasaE

Improved Ca and P metabolism
PTH suppression

Oral falecalcitriol treatment was effective for PTH suppression and Ca and P metabolism in hemodialysis patients with moderate to severe SHPT, similar to intravenous calcitriol administration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects.

Author: ZemelMichael B, SunXiaocun, SobhaniTeresa, WilsonBeth

Reduced inflammatory stress
Reduced oxidative stress

Calcitriol, a form of vitamin D, increases oxidative and inflammatory stress in obese mice. However, a high-calcium diet can reduce oxidative and inflammatory stress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Comparison of calcitriol versus cholecalciferol therapy in addition to oral calcium after total thyroidectomy with central neck lymph node dissection: a prospective randomized study.

Author: ChoeJun-Ho, KimWan Wook, LeeSe-Kyung, LimHye In, ChoiJae Hyuck, LeeJeong Eon, KimJung-Han, NamSeok Jin, YangJung-Hyun, KimJee Soo

Hypocalcemia treatment

Routine oral calcium and vitamin D supplementation was found to be beneficial after total thyroidectomy with central neck dissection. Calcitriol was more effective than cholecalciferol in treating postoperative hypocalcemia when taken after the onset of symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Management of osteoporosis with calcitriol in elderly Chinese patients: a systematic review.

Author: LiaoRuo-xi, YuMiao, JiangYan, XiaWeibo

Osteoporosis treatment
Hypercalcemia
Hypercalciuria

Calcitriol, an active vitamin D metabolite, is recommended for managing osteoporosis in China. This review summarizes six randomized controlled trials on calcitriol monotherapy and five trials on combined therapy. The findings suggest that calcitriol monotherapy can improve bone mineral density but may be insufficient for long-term treatment. Combined therapy with other bone agents is well-tolerated and demonstrates additional bone-preserving effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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